Schizanrins [corrected] B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities

  • J Nat Prod. 2001 Apr;64(4):487-90. doi: 10.1021/np000261m.
Y H Kuo  1 ,  S Y Li ,  R L Huang ,  M D Wu ,  H C Huang ,  K H Lee
Affiliations
  • 1. National Research Institute of Chinese Medicine, 155-1, Sec. 2, Li-Nong Street, Shih-Pai, Taipei 112, Taiwan, Republic of China.
PMID: 11325232 DOI: 10.1021/np000261m
Abstract

Bioassay-directed fractionation of ethanolic extract of Kadsura matsudai Hayata has resulted in the isolation of four novel C(18) dibenzocyclooctadiene Lignans, schizanrin B (1), schizanrin C (2), schizanrin D (3), and schizanrin E (4). Schizanrin B (1) showed moderate to strong activity for antihepatitis in both anti-HBsAg and anti-HBeAg assays, and 3 and 4 also were active in the latter assay [corrected]. Compounds 1--4 were inactive in vitro against HIV replication in H9 lymphocytes. All new structures were elucidated using spectral analysis. Their structural elucidation by spectral and structure--activity relationships is also discussed.

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