Ainuovirine
Ainuovirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). Ainuovirine inhibits HIV replication by non-competitively binding to HIV reverse transcriptase and blocking the reverse transcription process of viral RNA. Ainuovirine can be used for human immunodeficiency virus (HIV) type 1 infection.
For research use only. We do not sell to patients.
- CAS No.: 1097628-00-6
- Formula: C18H19N3O3
- Molecular Weight:325.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MT2 | EC50 |
6.1 nM
Compound: 10b
|
Antiviral activity against wild type HIV1 infected in human MT2 cells
Antiviral activity against wild type HIV1 infected in human MT2 cells
|
[PMID: 20138513] |
| MT2 | EC50 |
6.4 nM
Compound: 10b
|
Antiviral activity against NNRTI-resistant HIV1 harboring reverse transcriptase K103N mutant infected in human MT2 cells
Antiviral activity against NNRTI-resistant HIV1 harboring reverse transcriptase K103N mutant infected in human MT2 cells
|
[PMID: 20138513] |
| MT2 | EC50 |
9.6 nM
Compound: 10b
|
Antiviral activity against HIV1 harboring reverse transcriptase Y181C mutant infected in human MT2 cells
Antiviral activity against HIV1 harboring reverse transcriptase Y181C mutant infected in human MT2 cells
|
[PMID: 20138513] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 1097628-00-6
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Molecular Weight 325.36
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Formula C18H19N3O3
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SMILES
N#CC1=CC(C)=CC(C(C2=C(C(C)C)C(NC(N2CC)=O)=O)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)