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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

KCa channels

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Akt (1) Calcium Channel (1) Dengue Virus (10) ERK (1) Flavivirus (10) Isotope-Labeled Compounds (3) NO Synthase (1) Parasite (11) Piezo Channel (1) Potassium Channel (47) Reference Standards (10) TGF-beta/Smad (6) TRP Channel (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (17) Infection (9) Inflammation/Immunology (8) Metabolic Disease (6) Neurological Disease (11)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18723

Yoda 1 Maximum Cited Publications 100 Publications Verification	Piezo Channel Akt ERK Potassium Channel	Cardiovascular Disease
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca ²⁺ influx followed by activation of the calcium-activated potassium channel *KCa3.1* and inhibition of Rac1 activation .

HY-D0143

Quinine Maximum Cited Publications 7 Publications Verification	Flavivirus Dengue Virus Parasite Potassium Channel	Infection
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0252

Hydrochlorothiazide 5+ Cited Publications HCTZ	TGF-beta/Smad Potassium Channel	Cardiovascular Disease Metabolic Disease Cancer
Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0433A

Quinine hydrochloride dihydrate Maximum Cited Publications 7 Publications Verification	Flavivirus Dengue Virus Parasite Potassium Channel	Infection
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-50694

Senicapoc 10+ Cited Publications ICA-17043	Potassium Channel	Others
Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca ²⁺-activated K ⁺ channel; *KCa3.1) blocker with an IC₅₀* of 11 nM. Senicapoc blocks Ca ²⁺-induced rubidium flux from human RBCs with an IC₅₀ value of 11 nM and inhibits RBC dehydration with IC₅₀ of 30 nM .

HY-13103

NS 11021 3 Publications Verification	Potassium Channel	Others
NS 11021 is a potent and specific Ca ²⁺-activated big-conductance K ⁺ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials .

HY-P4121

L17E	Potassium Channel	Inflammation/Immunology Cancer
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .

HY-111655

SKA-31 4 Publications Verification	Potassium Channel	Cardiovascular Disease
SKA-31 is a potent potassium channel activator with EC_50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for *KCa3.1, KCa2.2, KCa2.1* and *KCa2.3*, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure .

HY-W010668

Quinine sulfate hydrate Maximum Cited Publications 7 Publications Verification	Flavivirus Dengue Virus Parasite Potassium Channel	Others
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-157557

AP30663	Potassium Channel	Cardiovascular Disease
AP30663 is a *KCa2* channel inhibitor that can be used for the study of atrial fibrillation .

HY-101422

GAL-021 5+ Cited Publications	Potassium Channel	Inflammation/Immunology
GAL-021 is a potent *BK_Ca-channel* blocker. GAL-021 inhibits K_Ca1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates .

HY-110153

NS19504	Potassium Channel	Neurological Disease
NS19504 is a Ca ²⁺-activated K ⁺ channel (BK channel, KCa1.1 channel) activator (EC₅₀=11.0 μM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions .

HY-D0143B

Quinine hemisulfate hydrate Maximum Cited Publications 7 Publications Verification	Parasite Potassium Channel	Infection
Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV, with an IC₅₀ of 169 μM .

HY-B0252S1

Hydrochlorothiazid-13C,d2 HCTZ-¹³C,d₂	Isotope-Labeled Compounds TGF-beta/Smad Potassium Channel	Cardiovascular Disease Metabolic Disease
Hydrochlorothiazid- ¹³C,d₂ is the ¹³C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0252R

Hydrochlorothiazide (Standard) 5+ Cited Publications HCTZ (Standard)	Reference Standards TGF-beta/Smad Potassium Channel	Cardiovascular Disease Metabolic Disease Cancer
Hydrochlorothiazide (Standard) is the analytical standard of Hydrochlorothiazide. This product is intended for research and analytical applications. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-D0143A

Quinine dihydrochloride	Flavivirus Dengue Virus Parasite Potassium Channel	Infection
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0252S

Hydrochlorothiazid-d2 HCTZ-d₂	TGF-beta/Smad Potassium Channel	Cardiovascular Disease Metabolic Disease
Hydrochlorothiazid-d₂ is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-15707

NS6180 1 Publications Verification	Potassium Channel	Inflammation/Immunology
NS6180 is a new orally active **KCa3.1 channel** inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC₅₀value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) .

HY-B0433B

Quinine hemisulfate	Flavivirus Dengue Virus Parasite Potassium Channel	Infection
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0252S3

Hydrochlorothiazide-15N2,13C,d2 HCTZ-¹⁵N₂,¹³C,d₂	Potassium Channel TGF-beta/Smad Isotope-Labeled Compounds	Cardiovascular Disease Metabolic Disease Cancer
Hydrochlorothiazide- ¹⁵N₂, ¹³C,d₂ is ¹⁵N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-121516

CM-TPMF	Potassium Channel	Others
CM-TPMF is a K(Ca)2 channel modulator with selective activation and inhibition of K(Ca)2.1 subtypes. CM-TPMF can act on K(Ca)2.1 channels as an activator or inhibitor, and its activity is affected by the stereochemical structure. It can be used to study the physiological or pathophysiological effects of K(Ca)2.1 channels.

HY-103308

TRAM-39	Potassium Channel	Neurological Disease
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IK_Ca) channels. TRAM-39 inhibits KCa3.1 channel with an IC₅₀ value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease .

HY-D0143R

Quinine (Standard)	Dengue Virus Flavivirus Reference Standards Parasite Potassium Channel	Infection
Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-W010668R

Quinine sulfate hydrate (Standard)	Flavivirus Dengue Virus Reference Standards Parasite Potassium Channel	Others
Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .

HY-146173

KCa1.1 channel activator-1	Potassium Channel Calcium Channel	Cardiovascular Disease
KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular **K_Ca1.1 channel** channel stimulator. KCa1.1 channel activator-1 also displays Ca_V1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity .

HY-142723

KCa2 channel modulator 1	Potassium Channel	Neurological Disease
KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of **K_Ca2 channel*. KCa2 channel* modulator 1 potentiates human K_Ca2.3 channels with an EC₅₀ value of 0.19 μM and 0.99 μM on the rat K_Ca2.2 channel subtype .

HY-146174

KCa1.1 channel activator-2	Potassium Channel	Cardiovascular Disease
KCa1.1 channel activator-2 (compound 3F), a Quercetin hybrid derivative, is a selective vascular **K_Ca1.1 channel** stimulator. KCa1.1 channel activator-2 exhibits potent myorelaxant activity .

HY-142735

KCa2 channel modulator 2	Potassium Channel	Neurological Disease
KCa2 channel modulator 2 (compound 2q) is a potent subtype-selective positive modulator of **K_Ca2 channel*. KCa2 channel* modulator 2 exhibits similar potency on the rat K_Ca2.2a and human K_Ca2.3 channel subtypes, with EC₅₀s of 0.64 μM and 0.60 μM, respectively

HY-P1424

Lei-Dab7	Potassium Channel	Neurological Disease
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels .

HY-120355A

AP14145 hydrochloride	Potassium Channel	Cardiovascular Disease
AP14145 hydrochloride is a potent K_Ca2 (SK) channel negative allosteric modulator with an IC₅₀ of 1.1 μM for K_Ca2.2 (SK2) and K_Ca2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) .

HY-120355

AP14145	Potassium Channel	Cardiovascular Disease
AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits **K_Ca2.2 channel and K_Ca channel with IC₅₀** of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect .

HY-128126

B-TPMF	Potassium Channel	Cardiovascular Disease
B-TPMF is a selective inhibitor of the KCa2.1 channel, with an IC₅₀ of 30 nM, and it has a competitive functional interaction with CM-TPMF .

HY-P1424A

Lei-Dab7 TFA	Potassium Channel	Neurological Disease
Lei-Dab7 TFA is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, K_v and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

HY-111655R

SKA-31 (Standard)	Potassium Channel	Cardiovascular Disease
SKA-31 (Standard) is the analytical standard of SKA-31. This product is intended for research and analytical applications. SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure .

HY-118689

RA-2	Potassium Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
RA-2 is a negative-gating modulator of **KCa2/3 channels with an IC₅₀** of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation .

HY-W740048

Quinine-d3	Isotope-Labeled Compounds Potassium Channel Parasite Flavivirus Dengue Virus	Infection
Quinine-d₃ is the deuterium labeled Quinine (HY-D0143). Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

HY-B0433AR

Quinine hydrochloride dihydrate (Standard)	Dengue Virus Flavivirus Reference Standards Parasite Potassium Channel	Infection
Quinine (hydrochloride dihydrate) (Standard) is the analytical standard of Quinine (hydrochloride dihydrate). This product is intended for research and analytical applications. Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

HY-D0143AR

Quinine dihydrochloride (Standard)	Flavivirus Dengue Virus Reference Standards Parasite Potassium Channel	Infection
Quinine (dihydrochloride) (Standard) is the analytical standard of Quinine (dihydrochloride). This product is intended for research and analytical applications. Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .

HY-50694R

Senicapoc (Standard) ICA-17043 (Standard)	Potassium Channel Reference Standards	Others
Senicapoc (Standard) is the analytical standard of Senicapoc. This product is intended for research and analytical applications. Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM .

HY-120514

JNc-440	TRP Channel Potassium Channel	Cardiovascular Disease
JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca ²⁺-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice .

HY-P3316

OSK-1	Potassium Channel	Neurological Disease Inflammation/Immunology
OSK-1 is a potent K_v channel blocker with IC₅₀s of of 0.6 nM, 5.4 nM, 0.014 nM for K_v1.1, K_v1.2 and K_v1.3, respectively. OSK1 is a moderate blocker of Ca ²⁺-activated K_Ca3.1 channel with an IC₅₀ of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent .

HY-117651R

2-Fluoropalmitic acid (Standard)	Reference Standards Acyltransferase	Cancer
Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .

HY-101422A

GAL-021 sulfate	Potassium Channel	Inflammation/Immunology
GAL-021 sulfate is a potent *BK_Ca-channel* blocker. GAL-021 sulfate inhibits K_Ca1.1 in GH3 cells. GAL-021 sulfate is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 sulfate increases minute ventilation in rats and non-human primates .

HY-P3064

Scyllatoxin Leiurotoxin I	Potassium Channel	Neurological Disease
Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance K_Ca (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo .

HY-B0252S2

Hydrochlorothiazide-13C6 HCTZ-¹³C₆	TGF-beta/Smad Potassium Channel	Metabolic Disease
Hydrochlorothiazide- ¹³C₆ is the ¹³C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-181755

Phenylaminojuglone AJ-2	NO Synthase	Inflammation/Immunology
Phenylaminojuglone AJ-2 is a nitric oxide synthase inhibitor that interacts with soluble guanylate cyclase, β-adrenergic receptor, CaV1.2 calcium channel, KV channel and *KCa* channel. Phenylaminojuglone AJ-2 blocks extracellular Ca ²⁺ influx, regulates the activity of the NO?sGC?cGMP signaling pathway, and inhibits pharmacologic and electromechanical contractions of smooth muscle. Phenylaminojuglone AJ-2 is applicable to studies related to intestinal spasm .

HY-103308R

TRAM-39 (Standard)	Reference Standards Potassium Channel	Neurological Disease
TRAM-39 (Standard) is the analytical standard of TRAM-39 (HY-103308). This product is intended for research and analytical applications. TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC₅₀ value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease .

HY-101422R

GAL-021 (Standard)	Potassium Channel Reference Standards	Inflammation/Immunology
GAL-021 (Standard) is the analytical standard of GAL-021 (HY-101422). This product is intended for research and analytical applications. GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates .

HY-101360R

1-EBIO (Standard) 1-Ethyl-2-benzimidazolinone (Standard)	Potassium Channel Reference Standards	Cardiovascular Disease Neurological Disease Cancer
1-EBIO (1-Ethyl-2-benzimidazolinone) (Standard) is the analytical standard of 1-EBIO (HY-101360). This product is intended for research and analytical applications. 1-EBIO is an activator of Ca ²⁺ sensitive K ⁺ channels wirh an EC₅₀ of 136 μM for K_Ca3.1. 1-EBIO induces Cl ^- secretion, K ⁺ conductance, membrane hyperpolarization, and afterhyperpolarisation currents. 1-EBIO reduces epileptiform activity, seizure incidence, and rescues cells from Ionomycin (HY-13434)-induced death .

Cat. No.	Product Name	Target	Research Area

HY-P4121

L17E	Potassium Channel	Inflammation/Immunology Cancer
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .

HY-P1424

Lei-Dab7	Potassium Channel	Neurological Disease
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels .

HY-P1424A

Lei-Dab7 TFA	Potassium Channel	Neurological Disease
Lei-Dab7 TFA is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, K_v and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

HY-P3316

OSK-1	Potassium Channel	Neurological Disease Inflammation/Immunology
OSK-1 is a potent K_v channel blocker with IC₅₀s of of 0.6 nM, 5.4 nM, 0.014 nM for K_v1.1, K_v1.2 and K_v1.3, respectively. OSK1 is a moderate blocker of Ca ²⁺-activated K_Ca3.1 channel with an IC₅₀ of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent .

HY-P3064

Scyllatoxin Leiurotoxin I	Potassium Channel	Neurological Disease
Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance K_Ca (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D0143

Quinine Maximum Cited Publications 7 Publications Verification	Cinchona succirubra Pav. ex Klotzsch Infection Alkaloids Classification of Application Fields Rubiaceae Quinoline Alkaloids Plants Disease Research Fields Source Classification	Flavivirus Dengue Virus Parasite Potassium Channel
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0433A

Quinine hydrochloride dihydrate Maximum Cited Publications 7 Publications Verification	Infection Alkaloids Classification of Application Fields Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Source Classification	Flavivirus Dengue Virus Parasite Potassium Channel
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-W010668

Quinine sulfate hydrate Maximum Cited Publications 7 Publications Verification	Plants Source Classification	Flavivirus Dengue Virus Parasite Potassium Channel
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-D0143B

Quinine hemisulfate hydrate Maximum Cited Publications 7 Publications Verification	Infection Alkaloids Classification of Application Fields Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Source Classification	Parasite Potassium Channel
Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV, with an IC₅₀ of 169 μM .

HY-D0143A

Quinine dihydrochloride	Cinchona succirubra Pav. ex Klotzsch Structural Classification Alkaloids Piperidine Alkaloids Rubiaceae Plants Isoquinoline Alkaloids Source Classification	Flavivirus Dengue Virus Parasite Potassium Channel
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0433B

Quinine hemisulfate	Cinchona succirubra Pav. ex Klotzsch Rubiaceae Quinoline Alkaloids Plants Source Classification	Flavivirus Dengue Virus Parasite Potassium Channel
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-D0143R

Quinine (Standard)	Cinchona succirubra Pav. ex Klotzsch Alkaloids Structural Classification Rubiaceae Quinoline Alkaloids Plants Source Classification	Dengue Virus Flavivirus Reference Standards Parasite Potassium Channel
Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-W010668R

Quinine sulfate hydrate (Standard)	Plants Source Classification	Flavivirus Dengue Virus Reference Standards Parasite Potassium Channel
Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .

HY-B0433AR

Quinine hydrochloride dihydrate (Standard)	Alkaloids Structural Classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Source Classification	Dengue Virus Flavivirus Reference Standards Parasite Potassium Channel
Quinine (hydrochloride dihydrate) (Standard) is the analytical standard of Quinine (hydrochloride dihydrate). This product is intended for research and analytical applications. Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

HY-D0143AR

Quinine dihydrochloride (Standard)	Cinchona succirubra Pav. ex Klotzsch Natural Products Rubiaceae Plants Source Classification	Flavivirus Dengue Virus Reference Standards Parasite Potassium Channel
Quinine (dihydrochloride) (Standard) is the analytical standard of Quinine (dihydrochloride). This product is intended for research and analytical applications. Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0252S1

Hydrochlorothiazid-13C,d2

Hydrochlorothiazid- ¹³C,d₂ is the ¹³C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0252S

Hydrochlorothiazid-d2

Hydrochlorothiazid-d₂ is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0252S3

Hydrochlorothiazide-15N2,13C,d2

Hydrochlorothiazide- ¹⁵N₂, ¹³C,d₂ is ¹⁵N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-W740048

Quinine-d3
Quinine-d₃ is the deuterium labeled Quinine (HY-D0143). Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

HY-B0252S2

Hydrochlorothiazide-13C6

Hydrochlorothiazide- ¹³C₆ is the ¹³C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

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