GAL-021 sulfate
Based on 6 publication(s) in Google Scholar
GAL-021 sulfate is a potent BKCa-channel blocker. GAL-021 sulfate inhibits KCa1.1 in GH3 cells. GAL-021 sulfate is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 sulfate increases minute ventilation in rats and non-human primates.
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- CAS 番号: 1380342-00-6
- 分子式: C11H24N6O5S
- 分子量:352.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 GAL-021 sulfate
More- Pharmaceuticals (Basel). 2021 Apr 21;14(5):388. [Abstract]
- Eur J Pharmacol. 2020 Nov 15:887:173482. [Abstract]
- Biomolecules. 2020 Jan 25;10(2):188. [Abstract]
- Int J Mol Sci. 2020 Jan 5;21(1):357. [Abstract]
- BMC Pharmacol Toxicol. 2021 Jan 13;22(1):6. [Abstract]
- Oxid Med Cell Longev. 2022 Jun 20;2022:5905374. [Abstract]
生物活性
製品説明
化学情報
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CAS 番号 1380342-00-6
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分子量 352.41
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分子式 C11H24N6O5S
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SMILES
O=S(O)(O)=O.CCCNC1=NC(NCCC)=NC(N(C)OC)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
Effective Activation of BKCa Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4 H)-one), Known to Be an Opener of KCNQ2/Q3 Channels. [Abstract]2021 Apr 21;14(5):388. PMID: 33919092 -
Eur J Pharmacol
High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate IK(Ca) but suppress IK(DR) and IK(M) independently of 5-lipoxygenase inhibition. [Abstract]2020 Nov 15:887:173482. PMID: 32795513 -
Biomolecules
High Efficacy by GAL-021: A Known Intravenous Peripheral Chemoreceptor Modulator that Suppresses BKCa-Channel Activity and Inhibits IK(M) or Ih. [Abstract]2020 Jan 25;10(2):188. PMID: 31991782 -
Int J Mol Sci
Characterization of Effectiveness in Concerted Ih Inhibition and IK(Ca) Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4'-hydroxystilbene), a Stilbenoid. [Abstract]2020 Jan 5;21(1):357. PMID: 31948124 -
BMC Pharmacol Toxicol
Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells. [Abstract]2021 Jan 13;22(1):6. PMID: 33441172 -
Oxid Med Cell Longev
Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4-PGC-1 α-PPAR α/PPAR γ Signaling in Isolated Beating Rat Atria. [Abstract]2022 Jun 20;2022:5905374. PMID: 35770043
純度とドキュメンテーション
参考文献
[1]. Golder FJ, et al. Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator. Anesthesiology. 2015 Nov;123(5):1093-104. [Content Brief]
[2]. J F McLeod, et al. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. Br J Anaesth. 2014 Nov;113(5):875-83. [Content Brief]
Calculators
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GAL-021 sulfate 関連分類
HY-101422A 関連分類
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