1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. NS19504

NS19504 

Cat. No.: HY-110153
Handling Instructions

NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

For research use only. We do not sell to patients.

NS19504 Chemical Structure

NS19504 Chemical Structure

CAS No. : 327062-46-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 64 In-stock
Estimated Time of Arrival: December 31
5 mg USD 58 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 380 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].

IC50 & Target

EC50: 11.0 µM (BK channel)[1]

In Vitro

NS19504 increases BK currents in freshly isolated guinea pig bladder smooth muscle cells and whole-cell. NS19504 increases the whole-cell currents response to 127 %, 194 %, 258 %, 561 % of control at a concentration of 0.32 µM, 1.0 µM, 3.2 µM and 10 µM, respectively[1].

Molecular Weight

269.16

Formula

C₁₀H₉BrN₂S

CAS No.

327062-46-4

SMILES

NC1=NC=C(S1)CC2=CC=C(Br)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (928.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7153 mL 18.5763 mL 37.1526 mL
5 mM 0.7431 mL 3.7153 mL 7.4305 mL
10 mM 0.3715 mL 1.8576 mL 3.7153 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NS19504NS 19504NS-19504Potassium ChannelKcsAInhibitorinhibitorinhibit

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Product name:
NS19504
Cat. No.:
HY-110153
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