1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Lei-Dab7

Lei-Dab7 

Cat. No.: HY-P1424
Handling Instructions

Lei-Dab7 is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Lei-Dab7 Chemical Structure

Lei-Dab7 Chemical Structure

CAS No. : 1061556-49-7

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Description

Lei-Dab7 is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

Molecular Weight

3392.06

Formula

C₁₄₁H₂₃₆N₄₆O₃₉S₆

CAS No.

1061556-49-7

Sequence

Ala-Phe-Cys-Asn-Leu-Arg-{Dab}-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)

Sequence Shortening

AFCNLR{Dab}CQLSCRSLGLLGKCIGDKCECVKH-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Lei-Dab7Potassium ChannelKcsAInhibitorinhibitorinhibit

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