1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Lei-Dab7 TFA

Lei-Dab7 TFA 

Cat. No.: HY-P1424A
Handling Instructions

Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Lei-Dab7 TFA Chemical Structure

Lei-Dab7 TFA Chemical Structure

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Description

Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

Molecular Weight

3506.08

Formula

C₁₄₃H₂₃₇F₃N₄₆O₄₁S₆

Sequence

Ala-Phe-Cys-Asn-Leu-Arg-Asp-Ala-Asx-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)

Sequence Shortening

AFCNLR{Dab}CQLSCRSLGLLGKCIGDKCECVKH-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Lei-Dab7Potassium ChannelKcsAInhibitorinhibitorinhibit

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Lei-Dab7 TFA
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