1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. NS 11021

NS 11021 

Cat. No.: HY-13103 Purity: >98.0%
Handling Instructions

NS 11021 is a potent and specific Ca2-activated big-conductance K Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials.

For research use only. We do not sell to patients.

NS 11021 Chemical Structure

NS 11021 Chemical Structure

CAS No. : 956014-19-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 281 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

NS 11021 is a potent and specific Ca2-activated big-conductance K Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].

IC50 & Target

Ca2+-activated big-conductance K Channels[1]

Molecular Weight

511.24

Formula

C₁₆H₉BrF₆N₆S

CAS No.

956014-19-0

SMILES

S=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NN=NN3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (489.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9560 mL 9.7801 mL 19.5603 mL
5 mM 0.3912 mL 1.9560 mL 3.9121 mL
10 mM 0.1956 mL 0.9780 mL 1.9560 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NS 11021NS11021NS-11021Potassium ChannelKcsAInhibitorinhibitorinhibit

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Product name:
NS 11021
Cat. No.:
HY-13103
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