Phenylaminojuglone AJ-2
Phenylaminojuglone AJ-2 is a nitric oxide synthase inhibitor that interacts with soluble guanylate cyclase, β-adrenergic receptor, CaV1.2 calcium channel, KV channel and KCa channel. Phenylaminojuglone AJ-2 blocks extracellular Ca2+ influx, regulates the activity of the NO?sGC?cGMP signaling pathway, and inhibits pharmacologic and electromechanical contractions of smooth muscle. Phenylaminojuglone AJ-2 is applicable to studies related to intestinal spasm.
For research use only. We do not sell to patients.
- CAS No.: 109621-29-6
- Formula: C16H11NO3
- Molecular Weight:265.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
3.13 μM
Compound: PD3
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Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
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[PMID: 23791367] |
Phenylaminojuglone AJ-2 binds with high affinity to M2, M3, β2, β3, nitric oxide synthase, guanylate cyclase, and Cav1.2 L-type voltage-gated calcium channel, with binding energies ranging from -8.3 to -10.0 kcal·mol?1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 109621-29-6
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Molecular Weight 265.26
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Formula C16H11NO3
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SMILES
O=C1C=C(C(C2=C(C=CC=C12)O)=O)NC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phenylaminojuglone AJ-2 Related Classifications
HY-181755 Related Classifications
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