2. Immunology/Inflammation
  3. NO Synthase
  4. Phenylaminojuglone AJ-2

Phenylaminojuglone AJ-2 is a nitric oxide synthase inhibitor that interacts with soluble guanylate cyclase, β-adrenergic receptor, CaV1.2 calcium channel, KV channel and KCa channel. Phenylaminojuglone AJ-2 blocks extracellular Ca2+ influx, regulates the activity of the NO?sGC?cGMP signaling pathway, and inhibits pharmacologic and electromechanical contractions of smooth muscle. Phenylaminojuglone AJ-2 is applicable to studies related to intestinal spasm.

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Phenylaminojuglone AJ-2

Phenylaminojuglone AJ-2 Chemical Structure

CAS No. : 109621-29-6

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Phenylaminojuglone AJ-2 Related Antibodies

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Description

Phenylaminojuglone AJ-2 is a nitric oxide synthase inhibitor that interacts with soluble guanylate cyclase, β-adrenergic receptor, CaV1.2 calcium channel, KV channel and KCa channel. Phenylaminojuglone AJ-2 blocks extracellular Ca2+ influx, regulates the activity of the NO?sGC?cGMP signaling pathway, and inhibits pharmacologic and electromechanical contractions of smooth muscle. Phenylaminojuglone AJ-2 is applicable to studies related to intestinal spasm[1].

In Vitro

Phenylaminojuglone AJ-2 binds with high affinity to M2, M3, β2, β3, nitric oxide synthase, guanylate cyclase, and Cav1.2 L-type voltage-gated calcium channel, with binding energies ranging from -8.3 to -10.0 kcal·mol?1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenylaminojuglone AJ-2 Related Antibodies
Molecular Weight

265.26

Formula

C16H11NO3
CAS No.
SMILES

O=C1C=C(C(C2=C(C=CC=C12)O)=O)NC3=CC=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Phenylaminojuglone AJ-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenylaminojuglone AJ-2109621-29-6Phenylaminojuglone AJ2Phenylaminojuglone AJ 2NO SynthaseNitric oxide synthasesNOSM3M2KV channelsKCa channelsβ-adrenergic receptorsβ2soluble guanylate cyclaseNO?sGC?cGMP signaling pathwaynitric oxide synthaseCaV1.2 calcium channelsInhibitorinhibitorinhibit

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