1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. TRAM-39

TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease.

For research use only. We do not sell to patients.

TRAM-39 Chemical Structure

TRAM-39 Chemical Structure

CAS No. : 197525-99-8

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5 mg USD 86 In-stock
10 mg USD 135 In-stock
25 mg USD 270 In-stock
50 mg USD 430 In-stock
100 mg USD 680 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease[1][2][3][4].

IC50 & Target

IC50: 60 nM (KCa3.1 channel)[4]

In Vitro

TRAM-39 (1 μM) reduces the peak amplitude of gKCa2 in sympathetic LAH neurons (mean percentage change 56%) in BAE cells[2].
TRAM-39 (200 nM) diminishes lipopolysaccharide (LPS)-induced cryptdin release from paneth cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TRAM-39 (1 μM; adds to the perfusate) fully blocks all IKCa channels in multicellular preparations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

303.78

Formula

C20H14ClN

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (164.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2919 mL 16.4593 mL 32.9186 mL
5 mM 0.6584 mL 3.2919 mL 6.5837 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2919 mL 16.4593 mL 32.9186 mL 82.2964 mL
5 mM 0.6584 mL 3.2919 mL 6.5837 mL 16.4593 mL
10 mM 0.3292 mL 1.6459 mL 3.2919 mL 8.2296 mL
15 mM 0.2195 mL 1.0973 mL 2.1946 mL 5.4864 mL
20 mM 0.1646 mL 0.8230 mL 1.6459 mL 4.1148 mL
25 mM 0.1317 mL 0.6584 mL 1.3167 mL 3.2919 mL
30 mM 0.1097 mL 0.5486 mL 1.0973 mL 2.7432 mL
40 mM 0.0823 mL 0.4115 mL 0.8230 mL 2.0574 mL
50 mM 0.0658 mL 0.3292 mL 0.6584 mL 1.6459 mL
60 mM 0.0549 mL 0.2743 mL 0.5486 mL 1.3716 mL
80 mM 0.0411 mL 0.2057 mL 0.4115 mL 1.0287 mL
100 mM 0.0329 mL 0.1646 mL 0.3292 mL 0.8230 mL
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TRAM-39 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TRAM-39
Cat. No.:
HY-103308
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