197525-99-8
197525-99-8
Chemical Structure
TRAM-39
- CAS 番号: 197525-99-8
- Formula:C20H14ClN
- Molecular Weight:303.78
IUPAC Name: 2-(2-chlorophenyl)-2,2-diphenylacetonitrile
InChIKey: JHNRTPKGSCVKKC-UHFFFAOYSA-N
SMILES: N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3Cl
Biological Activity: TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease[1][2][3][4].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
TRAM-39 | 98.90% | TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
TRAM-39 (Standard) | ≥98% | TRAM-39 (Standard) is the analytical standard of TRAM-39 (HY-103308). This product is intended for research and analytical applications. TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.84
HY-W0113312-Chlorotrityl chloride -
Similarity Score 0.83
HY-121914(2-Chlorophenyl)diphenylmethanol -
Similarity Score 0.73
HY-W011788Triphenylmethanol -
Similarity Score 0.72
HY-W009369Candesartan impurity 32 -
Similarity Score 0.68
HY-W012019Triphenylmethane -
Similarity Score 0.67
HY-W011418R4-Bromo-2,2-diphenylbutyronitrile (Standard) -
Similarity Score 0.66
HY-W150752Triphenylethylene -
Similarity Score 0.64
HY-W4747952-Phenyl-2,2-di(pyridin-4-yl)ethan-1-ol -
Similarity Score 0.64
![[1,1'-Biphenyl]-4-yl(phenyl)methanol (Standard) Chemical Structure](//file.medchemexpress.com/product_pic/hy-w322676r.gif)
HY-W322676R[1,1'-Biphenyl]-4-yl(phenyl)methanol (Standard) -
Explore the MedChemAI to find more analogs
![[1,1'-Biphenyl]-4-yl(phenyl)methanol (Standard) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w322676r.gif)
References
- [1]. Davies PJ, et al. Different types of potassium channels underlie the long afterhyperpolarization in guinea-pig sympathetic and enteric neurons. Auton Neurosci. 2006 Jan 30;124(1-2):26-30. [Content Brief]
- [2]. Burnham MP, et al. Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br J Pharmacol. 2006 Jun;148(4):434-41. [Content Brief]
- [3]. Ayabe T, et al. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 1;277(5):3793-800. [Content Brief]
- [4]. Wulff H, et al. Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57. [Content Brief]
