197525-99-8
197525-99-8
Chemical Structure
TRAM-39
- CAS No.: 197525-99-8
- Formula:C20H14ClN
- Molecular Weight:303.78
IUPAC Name: 2-(2-chlorophenyl)-2,2-diphenylacetonitrile
InChIKey: JHNRTPKGSCVKKC-UHFFFAOYSA-N
SMILES: N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3Cl
Biological Activity: TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TRAM-39 | 99.66% | TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease. | ||||||||||||||||||||
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TRAM-39 (Standard) | ≥98% | TRAM-39 (Standard) is the analytical standard of TRAM-39 (HY-103308). This product is intended for research and analytical applications. TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease. | ||||||||||||||||||||
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References
- [1]. Davies PJ, et al. Different types of potassium channels underlie the long afterhyperpolarization in guinea-pig sympathetic and enteric neurons. Auton Neurosci. 2006 Jan 30;124(1-2):26-30. [Content Brief]
- [2]. Burnham MP, et al. Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br J Pharmacol. 2006 Jun;148(4):434-41. [Content Brief]
- [3]. Ayabe T, et al. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 1;277(5):3793-800. [Content Brief]
- [4]. Wulff H, et al. Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57. [Content Brief]
Keywords
