2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. RA-2

RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation.

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RA-2 Chemical Structure

RA-2 Chemical Structure

CAS No. : 1867107-62-7

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Based on 1 publication(s) in Google Scholar

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Description

RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation[1].

Molecular Weight

414.36

Formula

C22H16F2O6
CAS No.
SMILES

O=C(C1=CC=C(C(F)=C1)O)OCC2=CC=CC(COC(C3=CC=C(C(F)=C3)O)=O)=C2
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Purity & Documentation
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RA-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RA-21867107-62-7RA2RA 2Potassium ChannelKcsAKCa2/3 channelsEDHvasculaturecentral nervous systeminflammationInhibitorinhibitorinhibit

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