1867107-62-7
Chemical Structure
RA-2
- CAS No.: 1867107-62-7
- Formula:C22H16F2O6
- Molecular Weight:414.36
IUPAC Name: 1,3-phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate)
InChIKey: XOZKRECPKXTNAK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(F)=C1)O)OCC2=CC=CC(COC(C3=CC=C(C(F)=C3)O)=O)=C2
Biological Activity: RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation[1].
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RA-2 | RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation. | |||||||||||||||||||||
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Keywords
