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Pao pi4k Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PI4K (18) 5-HT Receptor (1) Antibiotic (2) Apoptosis (4) ATM/ATR (1) Autophagy (1) Bacterial (11) Biochemical Assay Reagents (1) Endogenous Metabolite (5) Enterovirus (1) Environmental Pollutants (1) Fluorescent Dye (1) G-quadruplex (1) Histone Demethylase (1) Isotope-Labeled Compounds (1) MAP4K (1) Monoamine Oxidase (2) Parasite (11) Phosphatase (1) PI3K (5) PKG (2) Potassium Channel (1) Reference Standards (4) Small Interfering RNA (siRNA) (6) Virus Protease (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (26) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: PI4K Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12016

KU-55933 Maximum Cited Publications 62 Publications Verification	ATM/ATR Autophagy	Cancer
KU-55933 is a potent ATM inhibitor with an IC₅₀ and K_i of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

HY-113056A

N1-Acetylspermidine hydrochloride	Endogenous Metabolite Apoptosis	Cancer
N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research ^[4] .

HY-100621

MDL 72527 1 Publications Verification	Monoamine Oxidase	Neurological Disease
MDL 72527 is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects .

HY-106005

MMV390048 3 Publications Verification	Parasite PI4K	Infection
MMV390048 is a representative of a new chemical class of Plasmodium *PI4K* inhibitor (K_d ^app=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .

HY-12046

PIK-93 5+ Cited Publications	PI4K PI3K Virus Protease	Cancer
PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC₅₀ of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC₅₀ of 16 nM and 39 nM, respectively.

HY-N2594

Isoforsythiaside	Bacterial	Infection
Isoforsythiaside is an antioxidant and antibacterial phenylethanoid glycoside with MICs of 40.83, 40.83, and 81.66 μg/mL for Escherichia coli(E. coli), Pseudomonas aeruginosa(PAO), and Staphylococcus aureus (SA), respectively .

HY-12912

KDU691	PI4K Parasite	Infection
KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a **Plasmodium PI4K** inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites .

HY-115675

NC03	PI4K	Others
NC03 is a *PI4K2A* inhibitor and reducing agent. NC03 inhibits the activity of *PI4K2A, thereby reducing the production of PI4P* in the cellular compartments where *PI4K2A* functions. NC03 rapidly induces a decrease in *PI4P* pools in the Golgi and endosomal compartments. NC03 reduces *PI4P* production in Rab7-positive late endosomes .

HY-Q36392

JNJ-9350 2 Publications Verification	Histone Demethylase	Cancer
JNJ-9350, a chemical probe, is an inhibitor of spermine oxidase (SMOX) with an IC₅₀ value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC₅₀ value of 0.79 μM. JNJ-9350 can be used for the research of cancer .

HY-106012

PI4K-IN-1	PI4K PI3K	Cancer
PI4K-IN-1 (compound 44) is a potent *PI4KIII* inhibitor, with pIC₅₀ values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC₅₀ values of 4.0/<3.7/5.0/<4.1, respectively .

HY-131901

Phenylarsine oxide Oxophenylarsine; PhAsO; Arsenosobenzene	Environmental Pollutants Phosphatase	Others
Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC₅₀ of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization .

HY-112435

UCT943	PI4K Parasite	Infection
UCT943 is a next-generation Plasmodium falciparum *PI4K* inhibitor. UCT943 inhibits the P. vivax PI4K (PvPI4K) enzyme with an IC₅₀ of 23 nM .

HY-126369

Exametazime HM-Pao	Biochemical Assay Reagents	Others
Exametazime (HM-PAO) is a lipophilic agent used for the preparation of brain imaging radiopharmaceuticals. ⁹⁹Tcm-Exametazime is an effective in vitro leukocyte labeling agent .

HY-100603A

(S)-GSK-F1	PI3K PI4K	Infection
(S)-GSK-F1 (Compound 28) is an inhibitor for type III phosphatidylinositol 4-kinase α (PI4KIIIα). (S)-GSK-F1 inhibits PI4Kα, PI4Kβ, PI4Kγ, PI3Kα, PI3Kβ and PI3Kδ with pIC₅₀ of 8.3, 6.0, 5.6, 5.6, 5.1 and 5.6, respectively. (S)-GSK-F1 exhibits anti-hepatitis C virus (HCV) activity through inhibition of HCV replication. (S)-GSK-F1 exhibits moderate pharmacokinetic characters in rat model .

HY-103583

KDU731	PI4K Parasite	Infection
KDU731, an orally active C. parvum *PI4K* inhibitor with an IC₅₀ value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo . KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety .

HY-178775

PI4K-IN-3	PI4K Parasite MAP4K PI3K	Infection
PI4K-IN-3 (Compound 27) is an orally active *PI4K* inhibitor with an IC₅₀ of 1.9  nM for Plasmodium vivax PI4K. PI4K-IN-3 has no hERG channel inhibition and mammalian cytotoxicity. PI4K-IN-3 has significant selectivity against the human MINK1 and *MAP4K4* kinases but with low selectivity against human PI3Kα and PI4Kβ. PI4K-IN-3 has potent antimalarial activity and significantly reduces parasitaemia in NSG mice mouse models of Plasmodium falciparum malaria .

HY-174134

PI4Kβ/PKG-IN-2	PI4K PKG Parasite	Infection
PI4Kβ/PKG-IN-2 (Compound 20) is an orally active dual inhibitor of Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG). PI4Kβ/PKG-IN-2 has potent inhibitory effects on Plasmodium. PI4Kβ/PKG-IN-2 is promising for research of malaria .

HY-175557

PI4K-IN-2	PI4K Enterovirus	Infection
PI4K-IN-2 (Compound 30) is a highly selective type III phosphatidylinositol 4-kinase β (PI4KB) inhibitor (IC₅₀=0.015 μM). PI4K-IN-2 is promising for research of human rhinovirus (HRV) .

HY-150598

*CHMFL-PI4K-127*	PI4K PI3K	Infection
CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective *PfPI4K* (Plasmodium falciparum PI4K kinase) inhibitor, with an IC₅₀ of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC₅₀ of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy .

HY-175732

PI4Kβ-IN-1	PI4K Parasite	Infection
PI4Kβ-IN-1 is an orally active and selective PI4Kβ inhibitor, with an IC₅₀ of 0.9 nM. PI4Kβ-IN-1 exhibits inhibitory activity against all stages of the P. falciparum life cycle, including blood, liver, and transmission stages. PI4Kβ-IN-1 demonstrates potent antimalarial efficacy in the mouse model infected with Plasmodium falciparum. PI4Kβ-IN-1 can be used for the study of malaria caused by Plasmodium falciparum .

HY-174130

PI4Kβ/PKG-IN-1	Parasite PI4K PKG	Infection
PI4Kβ/PKG-IN-1 (Compound 19) is an orally active dual inhibitor targeting Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG). PI4Kβ/PKG-IN-1 exhibits potent antiplasmodial activity. PI4Kβ/PKG-IN-1 is promising for research of malaria .

HY-113056AR

N1-Acetylspermidine hydrochloride (Standard)	Endogenous Metabolite Apoptosis Reference Standards	Cancer
N1-Acetylspermidine (hydrochloride) (Standard) is the analytical standard of N1-Acetylspermidine (hydrochloride). This product is intended for research and analytical applications. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research ^[4] .

HY-D1267

PAO-Nap	Apoptosis	Cancer
PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase .

HY-D1268

Seph-PAO	Fluorescent Dye	Cancer
Seph-PAO is the modified PAO attached a sepharose fluorophore and is used to detect the thioredoxin reductase (TrxR) .

HY-129123

ML318	Antibiotic	Infection
ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC₅₀ of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC₅₀ of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions .

HY-163765

Antimalarial agent 41	PI4K Potassium Channel	Infection
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC₅₀ of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC₅₀ of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC₅₀ of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models .

HY-113056AS

N1-Acetylspermidine-d6 hydrochloride	Endogenous Metabolite	Cancer
N1-Acetylspermidine-d₆ (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA .

HY-RS10464

PI4K2A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PI4K2A Human Pre-designed siRNA Set A contains three designed siRNAs for PI4K2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PI4K2A Human Pre-designed siRNA Set A PI4K2A Human Pre-designed siRNA Set A

HY-RS20578

Pi4k2a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pi4k2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pi4k2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pi4k2a Mouse Pre-designed siRNA Set A Pi4k2a Mouse Pre-designed siRNA Set A

HY-RS10465

PI4K2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PI4K2B Human Pre-designed siRNA Set A contains three designed siRNAs for PI4K2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PI4K2B Human Pre-designed siRNA Set A PI4K2B Human Pre-designed siRNA Set A

HY-106005R

MMV390048 (Standard)	Reference Standards Parasite PI4K	Infection
MMV390048 (Standard) is the analytical standard of MMV390048 (HY-106005). This product is intended for research and analytical applications. MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .

HY-163481

Antibiofilm agent-6	Bacterial	Infection
Antibiofilm agent-6 (Compound 26c) is a quorum sensing inhibitor with strong antibiofilm effects that can inhibit the fluorescence intensity of PAO1-lasB-gfp and PAO1-pqsA-gfp in a concentration-dependent manner. Antibiofilm agent-6 can inhibit the production of pyocyanin and rhamnolipid. Antibiofilm agent-6 aids helps ciprofloxacin (HY-B0356) effectively eliminate the living bacteria in a mouse model infected with P. aeruginosa PAO1 .

HY-146304

YXL-13	Bacterial	Infection
YXL-13 is a potent **Pseudomonas aeruginosa (PAO1) inhibitor with an IC₅₀** value of 3.686 μM. YXL-13 can inhibit virulence factors and biofilm formation of PAO1. YXL-13 reduces the pathogenicity and agent resistance of PAO1 by inhibition of the quorum sensing (QS) system. YXL-13 can be used for researching anti-bacteria .

HY-103583R

KDU731 (Standard)	Reference Standards PI4K Parasite	Infection
KDU731 (Standard) is the analytical standard of KDU731 (HY-103583). This product is intended for research and analytical applications. KDU731, an orally active C. parvum PI4K inhibitor with an IC₅₀ value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo . KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety .

HY-W680647

MDL 72527 free base	Endogenous Metabolite	Neurological Disease
MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects .

HY-173270

Antibacterial synergist 3	Bacterial	Infection
Antibacterial synergist 3 is a dual-acting inhibitor of biofilm (IC₅₀ of *PAO1: 0.40 μM and IC₅₀* of PA14: 1.45 μM). Antibacterial synergist 3 reduces virulence production by inhibiting the quorum sensing (QS) system and induces iron deficiency in P. aeruginosa PAO1. Antibacterial synergist 3 enhances the efficacy of Tobramycin (HY-B0441) and Ciprofloxacin (HY-B0356) in a mouse wound infection model. Antibacterial synergist 3 can be used for the research of P. aeruginosa infections .

HY-170387

MRS8209	5-HT Receptor	Cardiovascular Disease
MRS8209 is the antagonist for serotonin receptor with a K_i of 4.27 nM for 5-HT2BR. MRS8209 exhibits protective effect on pressure at airway opening (PAO), and can be used in research of pulmonary fibrosis .

HY-163111

Antibacterial agent 170	Bacterial	Infection
Antibacterial agent 170 (compound 6b) is a potent antibacterial agent which inhibits the formation of P. aeruginosa PAO1 biofilm. Antibacterial agent 170 exhibits quorum sensing inhibitor effect by the las system. Antibacterial agent 170 can used in study microbial resistance .

HY-N2867

Andrographiside	Bacterial	Cancer
Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP) . Andrographiside is a novel biofilm inhibitor of Pseudomonas aeruginosa PAO1 by modulating quorum-sensing proteins .

HY-168928

Antibiofilm agent prodrug 1	Bacterial	Infection
Antibiofilm agent prodrug 1 (Compound 5c) exhibits antibacterial activity through inhibition of biofilm formation and iron uptake. Antibiofilm agent prodrug 1 inhibits P. aeruginosa PAO1 with a MIC of 1.07 μM. Antibiofilm agent prodrug 1 exhibits anti-infectious efficacy in C. elegans with improved survival rate .

HY-149881

Quorum sensing-IN-2	Bacterial	Infection
Quorum sensing-IN-2 (compound 23e) is a quorum sensing inhibitor, which can reduce the pathogenicity of bacteria without affecting bacterial growth. Quorum sensing-IN-2 inhibits bacterial infections with little hemolytic activity. Quorum sensing-IN-2 shows synergistic effect with Ciprofloxacin (HY-B0356) in the bacteremia model infected with P. aeruginosa PAO1 .

HY-RS27086

Pi4k2a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pi4k2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pi4k2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pi4k2a Rat Pre-designed siRNA Set A Pi4k2a Rat Pre-designed siRNA Set A

HY-113056AS1

N1-Acetylspermidine-d3 hydrochloride	Isotope-Labeled Compounds Apoptosis Endogenous Metabolite	Cancer
N1-Acetylspermidine-d₃ hydrochloride is the deuterium labeled N1-Acetylspermidine hydrochloride (HY-113056A). N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research ^[4] .

HY-RS20189

Pi4k2b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pi4k2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pi4k2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pi4k2b Mouse Pre-designed siRNA Set A Pi4k2b Mouse Pre-designed siRNA Set A

HY-RS26693

Pi4k2b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pi4k2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Pi4k2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pi4k2b Rat Pre-designed siRNA Set A Pi4k2b Rat Pre-designed siRNA Set A

HY-18746

KAI-407	Parasite PI4K	Infection
KAI-407 is an orally active inhibitor of Plasmodium *PI4K* kinase, which can broadly inhibit multiple stages of the parasite lifecycle. KAI-407 exhibits EC₅₀s of for the blood stage of malignant Plasmodium of 81 nM; for the liver schizonts of P. yoelii of 88 nM; and IC₅₀s for the liver schizonts and dormant bodies of P. cynomolgi of 0.64 μM and 0.69 μM respectively. KAI-407 can prevent Plasmodium berghei infection 100%. KAI-407 can be used for the study of vivax malaria .

HY-181713

Antibiofilm agent-19	Bacterial G-quadruplex	Infection
Antibiofilm agent-19 is an antibiofilm agent with iron-chelating activity. Antibiofilm agent-19 potently inhibits biofilm formation by wild-type PAO1 and the hyper-biofilm mutant strain PAO1-ΔwspF. Antibiofilm agent-19 promotes the formation of c-di-GMP G-quadruplexes and disrupts iron acquisition systems. It can be used in studies on antibacterial adjuvants .

HY-182675

Antibiotic adjuvant 5	Antibiotic Bacterial	Infection
Antibiotic adjuvant 5 (Compound 2) acts as an Antibiotic adjuvant. Antibiotic adjuvant 5 enhances the activity of Azithromycin (HY-17506), Clarithromycin (HY-17508), Doripenem (HY-B0187) and Rifampin (HY-B0272) against Pseudomonas aeruginosa PAO1. When used in combination with Azithromycin, Antibiotic adjuvant 5 increases the survival rate of Galleria mellonella during Pseudomonas aeruginosa PAO1 infection. Antibiotic adjuvant 5 is applicable for the research of Pseudomonas aeruginosa infection .

HY-100621R

MDL 72527 (Standard)	Monoamine Oxidase Reference Standards	Neurological Disease
MDL 72527 (Standard) is the analytical standard of MDL 72527 (HY-100621). This product is intended for research and analytical applications. MDL 72527 is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects .

HY-N16410

N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone 5-cis-C12-HSL	Bacterial	Infection
N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone (5-cis-C12-HSL) (Compound 2) is an acylated homoserine lactone. N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone can be isolated for Mesorhizobium sp. N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone restores protease and pyoverdin production of an AHL-deficient Pseudomonas aeruginosa PAO1 lasI rhlI double mutant. N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone has no significant antibacterial activity and cytotoxicity against tumor cells .

Cat. No.	Product Name

HY-L009

Kinase Inhibitor Library

3,849 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3,849 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

HY-L009M

Kinase Inhibitor Library Mini

270 compounds

Kinases is a class of enzymes that adds chemicals called phosphates to other molecules, such as sugars or proteins. Protein phosphorylation serves as a critical regulatory mechanism for numerous cellular processes including cell division, metabolism, and signal transduction, with approximately 50% of cellular functions in humans being regulated by kinase activity. In drug discovery, kinases represent a major category of therapeutic targets, and kinase inhibitors constitute an important class of pharmaceuticals that block the activity of specific disease-associated enzymes, particularly in cancer and inflammatory disorders. Small molecule kinase inhibitors represent one of the fastest-growing drug categories, having received U.S. Food and Drug Administration (FDA) approval for both oncological and non-oncological indications. As of September 2023, over 70 FDA-approved small molecule kinase inhibitors are commercially available.

The MCE Kinase Inhibitor Library Mini contains 270 kinase inhibitors primarily targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.), and carbohydrate kinases. This collection includes 1-3 highly specific representative compounds per target, optimized for screening of kinase-related drug targets in pharmaceutical research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113056A

N1-Acetylspermidine hydrochloride	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Apoptosis
N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research ^[4] .

HY-N2594

Isoforsythiaside	Infection Oleaceae Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Disease Research Fields Source Classification	Bacterial
Isoforsythiaside is an antioxidant and antibacterial phenylethanoid glycoside with MICs of 40.83, 40.83, and 81.66 μg/mL for Escherichia coli(E. coli), Pseudomonas aeruginosa(PAO), and Staphylococcus aureus (SA), respectively .

HY-113056AR

N1-Acetylspermidine hydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Apoptosis Reference Standards
N1-Acetylspermidine (hydrochloride) (Standard) is the analytical standard of N1-Acetylspermidine (hydrochloride). This product is intended for research and analytical applications. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research ^[4] .

HY-N2867

Andrographiside	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	Bacterial
Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP) . Andrographiside is a novel biofilm inhibitor of Pseudomonas aeruginosa PAO1 by modulating quorum-sensing proteins .

HY-N16410

N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone 5-cis-C12-HSL	Natural Products Microorganisms Source Classification	Bacterial
N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone (5-cis-C12-HSL) (Compound 2) is an acylated homoserine lactone. N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone can be isolated for Mesorhizobium sp. N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone restores protease and pyoverdin production of an AHL-deficient Pseudomonas aeruginosa PAO1 lasI rhlI double mutant. N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone has no significant antibacterial activity and cytotoxicity against tumor cells .

Species:	Human (3)
Tag:	His (4) Strep (1) GST (3)
Source:	Sf9 insect cells (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703335

	PI4K2A Protein, Human (His, GST) Phosphatidylinositol 4-kinase type 2-alpha; Phosphatidylinositol 4-kinase type II-alpha; pi4k2A; Homo sapiens; Human; Kinase; Transferase; 2.7.1.67	Human	E. coli
	PI4K2A Protein, Human (His, GST) is the recombinant human-derived PI4K2A, expressed by E. coli , with His, GST labeled tag. ,

HY-P701742

	PI4KB Protein, Human (Active, sf9, His, GST) pi4kB; Phosphatidylinositol 4-kinase beta; pi4k-beta; pi4kbeta; PtdIns 4-kinase beta; NpiK; pi4k92; pi4kIII	Human	Sf9 insect cells
	The PI4KB protein is a key enzyme that initiates the production of 1,4,5-trisphosphate inositol (PIP) by phosphorylating phosphatidylinositol (PI). In addition to myo-inositol signaling, it is involved in mitotic Golgi disassembly and Golgi-to-plasma membrane trafficking, which is critical for cell membrane dynamics. PI4KB Protein, Human (sf9, His, GST) is the recombinant human-derived PI4KB protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

HY-P703333

	PI4K2B Protein, Human (sf9, His, GST) Phosphatidylinositol 4-kinase type 2-beta; Phosphatidylinositol 4-kinase type II-beta; pi4kII-BETA; pi4k2B; Homo sapiens; Human; pi4kII-BETA; Kinase; Transferase; 2.7.1.67	Human	Sf9 insect cells
	PI4K2B Protein, Human (sf9, His, GST) is the recombinant human-derived PI4K2B, expressed by sf9 insect cells , with His, GST labeled tag. ,

HY-P703424

	TSI3 Protein, Pseudomonas aeruginosa (His, Strep) Immune protein Tsi3; Anti-toxin protein Tsi3; tsi3; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / Pao1)	Others	E. coli
	TSI3 Protein, Pseudomonas aeruginosa (His, Strep) is the recombinant TSI3, expressed by E. coli , with Strep, His labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-113056AS

N1-Acetylspermidine-d6 hydrochloride

N1-Acetylspermidine-d₆ (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA .

HY-113056AS1

N1-Acetylspermidine-d3 hydrochloride

N1-Acetylspermidine-d₃ hydrochloride is the deuterium labeled N1-Acetylspermidine hydrochloride (HY-113056A). N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research ^[4] .

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