Antibiotic adjuvant 5
Antibiotic adjuvant 5 (Compound 2) acts as an Antibiotic adjuvant. Antibiotic adjuvant 5 enhances the activity of Azithromycin (HY-17506), Clarithromycin (HY-17508), Doripenem (HY-B0187) and Rifampin (HY-B0272) against *Pseudomonas aeruginosa* PAO1. When used in combination with Azithromycin, Antibiotic adjuvant 5 increases the survival rate of *Galleria mellonella* during *Pseudomonas aeruginosa* PAO1 infection. Antibiotic adjuvant 5 is applicable for the research of *Pseudomonas aeruginosa* infection.
For research use only. We do not sell to patients.
- CAS No.: 2292113-87-0
- Formula: C10H17N7
- Molecular Weight:235.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Antibiotic adjuvant 5 (60 μM; 16 h) dose-dependently enhances the activity of Azithromycin against *Pseudomonas aeruginosa* PAO1, reducing the MIC of Azithromycin by up to 1024-fold[1].
Antibiotic adjuvant 5 (60 μM; 1 h) increases the membrane permeability of *Pseudomonas aeruginosa* PAO1 by 50% at 60 μM[1].
Antibiotic adjuvant 5 (16 h) enhances the activity of Azithromycin against *Pseudomonas aeruginosa* PAO1 by 512-fold in an extremely low-salt medium[1].
Antibiotic adjuvant 5 (60 μM; 16 h) enhances the activities of Clarithromycin, Doripenem and Rifampin against *Pseudomonas aeruginosa* PAO1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:greater wax moth larvae (weight 200-300 mg)[1]
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Dosage:50 mg/kg (alone); 50 mg/kg (in combination with 50 mg/kg azithromycin); 400 mg/kg (alone)
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Administration:injection; single dose
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Result:Did not improve survival compared to untreated, infected larvae.
Achieved a 43% survival rate after 6 days when combined with 50 mg/kg azithromycin.
Resulted in 100% larval survival after 6 days at 400 mg/kg.
Chemical Information
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CAS No. 2292113-87-0
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Molecular Weight 235.29
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Formula C10H17N7
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SMILES
NC1=NC=C(C(CCCN)C2=CN=C(N2)N)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibiotic adjuvant 5 Related Classifications
HY-182675 Related Classifications
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