2. Anti-infection
  3. Antibiotic Bacterial
  4. Antibiotic adjuvant 5

Antibiotic adjuvant 5 (Compound 2) acts as an Antibiotic adjuvant. Antibiotic adjuvant 5 enhances the activity of Azithromycin (HY-17506), Clarithromycin (HY-17508), Doripenem (HY-B0187) and Rifampin (HY-B0272) against *Pseudomonas aeruginosa* PAO1. When used in combination with Azithromycin, Antibiotic adjuvant 5 increases the survival rate of *Galleria mellonella* during *Pseudomonas aeruginosa* PAO1 infection. Antibiotic adjuvant 5 is applicable for the research of *Pseudomonas aeruginosa* infection.

For research use only. We do not sell to patients.

Antibiotic adjuvant 5

Antibiotic adjuvant 5 Chemical Structure

CAS No. : 2292113-87-0

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Antibiotic adjuvant 5 Related Antibodies

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Description

Antibiotic adjuvant 5 (Compound 2) acts as an Antibiotic adjuvant. Antibiotic adjuvant 5 enhances the activity of Azithromycin (HY-17506), Clarithromycin (HY-17508), Doripenem (HY-B0187) and Rifampin (HY-B0272) against *Pseudomonas aeruginosa* PAO1. When used in combination with Azithromycin, Antibiotic adjuvant 5 increases the survival rate of *Galleria mellonella* during *Pseudomonas aeruginosa* PAO1 infection. Antibiotic adjuvant 5 is applicable for the research of *Pseudomonas aeruginosa* infection[1].

In Vitro

Antibiotic adjuvant 5 (60 μM; 16 h) dose-dependently enhances the activity of Azithromycin against *Pseudomonas aeruginosa* PAO1, reducing the MIC of Azithromycin by up to 1024-fold[1].
Antibiotic adjuvant 5 (60 μM; 1 h) increases the membrane permeability of *Pseudomonas aeruginosa* PAO1 by 50% at 60 μM[1].
Antibiotic adjuvant 5 (16 h) enhances the activity of Azithromycin against *Pseudomonas aeruginosa* PAO1 by 512-fold in an extremely low-salt medium[1].
Antibiotic adjuvant 5 (60 μM; 16 h) enhances the activities of Clarithromycin, Doripenem and Rifampin against *Pseudomonas aeruginosa* PAO1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibiotic adjuvant 5 Related Antibodies
In Vivo

Antibacterial agent 335 (50-400 mg/kg; injection; single dose) in combination with 50 mg/kg azithromycin achieves a 43% survival rate in Galleria mellonella infected with Pseudomonas aeruginosa PAO1, while 400 mg/kg alone shows no toxicity in this model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: greater wax moth larvae (weight 200-300 mg)[1]
Dosage: 50 mg/kg (alone); 50 mg/kg (in combination with 50 mg/kg azithromycin); 400 mg/kg (alone)
Administration: injection; single dose
Result: Did not improve survival compared to untreated, infected larvae.
Achieved a 43% survival rate after 6 days when combined with 50 mg/kg azithromycin.
Resulted in 100% larval survival after 6 days at 400 mg/kg.
Molecular Weight

235.29

Formula

C10H17N7
CAS No.
SMILES

NC1=NC=C(C(CCCN)C2=CN=C(N2)N)N1
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Antibiotic adjuvant 5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibiotic adjuvant 52292113-87-0Antibiotic adjuvant5Antibiotic adjuvant-5AntibioticBacterialdoripenemFe(II)sheep blood cellsMn(II)azithromycinrifampincystic fibrosis-associated Pseudomonas aeruginosa isolatesclarithromycinGalleria mellonellaPseudomonas aeruginosa PAO1Inhibitorinhibitorinhibit

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