1. Anti-infection
  2. Bacterial Antibiotic
  3. Doripenem

Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria.

For research use only. We do not sell to patients.

Doripenem Chemical Structure

Doripenem Chemical Structure

CAS No. : 148016-81-3

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Description

Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria[1][2].

IC50 & Target

β-lactam

 

In Vivo

Doripenem (S 4661; MIC range of 2 to 16 μg/ml; Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections) monohydrate demonstrates antibacterial killing for P. aeruginosa[1].
Doripenem (10, 50, 150 mg/kg; 0.2-ml volumes; subcutaneously 2 h) has a T1/2 of 0.41 hours, a CL of 673.9 mL/h•kg for mice with 10 mg/kg[1].
Pharmacokinetic Parameters of Doripenem in mice[1].

SC (10 mg/kg) SC (50 mg/kg) SC (150 mg/kg)
Tmax (h) 0.25 0.38 0.22
Cmax (μg/mL) 16.3 59.7 194.4
AUC0-24 (ng∗h /mL) 13.5 62.4 168
t1/2 (h) 0.41 0.34 0.44
CL (mL/h/kg) 673.9 783.3 850.5
V (mL/kg) 400.7 384.7 545.8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific-pathogen-free, female ICR mice weighing approximately 25 g with P. aeruginosa-infected thighs[1]
Dosage: MIC range of 2 to 16 μg/ml
Administration: Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections
Result: Demonstrated antibacterial killing for P. aeruginosa.
Clinical Trial
Molecular Weight

420.50

Formula

C15H24N4O6S2

CAS No.
SMILES

O=C(C(N12)=C(S[C@@H]3CN[C@H](CNS(=O)(N)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Doripenem Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Doripenem
Cat. No.:
HY-B0187
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