1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Doripenem monohydrate

Doripenem monohydrate (Synonyms: S 4661 monohydrate)

Cat. No.: HY-B0187A Purity: 99.97%
Handling Instructions

Doripenem monohydrate is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens.

For research use only. We do not sell to patients.

Doripenem monohydrate Chemical Structure

Doripenem monohydrate Chemical Structure

CAS No. : 364622-82-2

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg USD 360 In-stock
Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

Other Forms of Doripenem monohydrate:

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Description

Doripenem monohydrate is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens. Target: Antibacterial Doripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem. Doripenem appears as crystalline powder anywhere from a white to somewhat yellowish colour.Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also solution in N,N-dimethylformamide. Doripenem's chemical configuration has 6 asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powered drug can form a monohydrate when mixed with water. However, Doripenem has not been proven to possess polymorphism.

Clinical Trial
Molecular Weight

438.52

Formula

C₁₅H₂₆N₄O₇S₂

CAS No.
SMILES

O=C(C(N12)=C(S[[email protected]@H]3CN[[email protected]](CNS(=O)(N)=O)C3)[[email protected]](C)[[email protected]]2([H])[[email protected]@H]([[email protected]](O)C)C1=O)O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (114.02 mM; Need ultrasonic)

H2O : 10 mg/mL (22.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2804 mL 11.4020 mL 22.8040 mL
5 mM 0.4561 mL 2.2804 mL 4.5608 mL
10 mM 0.2280 mL 1.1402 mL 2.2804 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (6.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (6.84 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (6.84 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (76.01 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

DoripenemS 4661S4661S-4661BacterialAntibioticInhibitorinhibitorinhibit

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Doripenem monohydrate
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