364622-82-2
364622-82-2
Chemical Structure
Doripenem monohydrate
Synonym(s): S 4661 monohydrate
- CAS No.: 364622-82-2
- Formula:C15H26N4O7S2
- Molecular Weight:438.52
IUPAC Name: (4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
InChIKey: NTUBEBXBDGKBTJ-WGLOMNHJSA-N
SMILES: O=C(C(N12)=C(S[C@@H]3CN[C@H](CNS(=O)(N)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.O
Biological Activity: Doripenem (S 4661) monohydrate, a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Doripenem monohydrate | 99.86% | Doripenem (S 4661) monohydrate, a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria. | ||||||||||||||||||||
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Doripenem monohydrate (Standard) | 99.36% | Doripenem (monohydrate) (Standard) is the analytical standard of Doripenem (monohydrate). This product is intended for research and analytical applications. Doripenem (S 4661) monohydrate, a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria. | ||||||||||||||||||||
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References
- [1]. Aryun Kim, et al. In vivo pharmacodynamic profiling of doripenem against Pseudomonas aeruginosa by simulating human exposures. Antimicrob Agents Chemother. 2008 Jul;52(7):2497-502. [Content Brief]
- [2]. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9. [Content Brief]
