Antibacterial synergist 3
Antibacterial synergist 3 is a dual-acting inhibitor of biofilm (IC50 of PAO1: 0.40 μM and IC50 of PA14: 1.45 μM). Antibacterial synergist 3 reduces virulence production by inhibiting the quorum sensing (QS) system and induces iron deficiency in P. aeruginosa PAO1. Antibacterial synergist 3 enhances the efficacy of Tobramycin (HY-B0441) and Ciprofloxacin (HY-B0356) in a mouse wound infection model. Antibacterial synergist 3 can be used for the research of P. aeruginosa infections.
For research use only. We do not sell to patients.
- Formula: C15H20N4O4S
- Molecular Weight:352.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibacterial synergist 3 (compound JH21) (0.15625-2.5 μM) reduces the biofilm formation rate of P. aeruginosa PAO1 in a concentration-dependent manner[1].
Antibacterial synergist 3 (0.3125-10 μM) reduces the production of P. aeruginosa virulence factors elastase (43%) and pyocyanin (42%), and decreases the production of biofilm matrix exopolysaccharides (58%)[1].
Antibacterial synergist 3 (0.3125-10 μM) suppresses the fluorescence of PAO1-lasB-gfp and PAO1-pqsA-gfp strains but has no effect on the fluorescence of PAO1-gfp and its growth, indicating that it inhibits both the las and pqs systems[1].
Antibacterial synergist 3 (0.3125-10 μM) reduces the iron content of P. aeruginosa PAO1 (57%)[1].
Antibacterial synergist 3 (0.3125-10 μM) inhibits the swarming (84%) and swimming (64%) motility of P. aeruginosa PAO1 in a concentration-dependent manner[1].
Antibacterial synergist 3 (1.25-40 μM) shows no significant hemolytic effect on mouse and rabbit erythrocytes, indicating that it has good biosafety[1].
Antibacterial synergist 3 (1.25-100 μM) shows no cytotoxicity to RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Antibacterial synergist 3 (2.5 μM, topical, 3 d) combined with Ciprofloxacin (HY-B0356) (0.001 mg/mL) can reduce the survival rate of P. aeruginosa in the mouse wound infection model (0.45%) and significantly increase the antibacterial effect of Ciprofloxacin (HY-B0356) (1000 times)[1].
Antibacterial synergist 3 (0-100 μM, 0-120 h) does not affect the survival rate of zebrafish larvae (100%) in the zebrafish model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse wound infection model, female mice (4-week-old, babl/c) were infected with PAO1 (5 × 108 CFU in 0.9% saline)[1]
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Dosage:2.5 μM
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Administration:Topical, 3 d
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Result:Compared with the use of 0.5 mg/mL Tobramycin alone, the antibacterial rate (0.97%/0.22%) and wound healing rate (35%/36%) were equivalent, and the efficacy was improved by 200 times.
Compared with the use of 1 mg/mL Ciprofloxacin alone, the antibacterial rate (0.45%/0%) and wound healing rate (38%/39%) were equivalent, and the efficacy was improved by 1000 times.
Chemical Information
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Molecular Weight 352.41
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Formula C15H20N4O4S
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SMILES
ONC(CCCCNC(CNC1=NC2=CC=C(C=C2S1)OC)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial synergist 3 Related Classifications
HY-173270 Related Classifications
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