1. PI3K/Akt/mTOR
  2. PI4K

UCT943 

Cat. No.: HY-112435
Handling Instructions

UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943 inhibits the P. vivax PI4K (PvPI4K) enzyme with an IC50 of 23 nM.

For research use only. We do not sell to patients.

UCT943 Chemical Structure

UCT943 Chemical Structure

CAS No. : 1450666-80-4

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943 inhibits the P. vivax PI4K (PvPI4K) enzyme with an IC50 of 23 nM[1].

In Vitro

UCT943 maintains high in vitro selectivity (>200-fold) for the parasite PvPI4K versus the human PI4Kβ isozyme (IC50 of PI4Kβ, 5.4 μM), inhibition of which is linked to immunosuppressive effects[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3396 mL 11.6981 mL 23.3962 mL
5 mM 0.4679 mL 2.3396 mL 4.6792 mL
10 mM 0.2340 mL 1.1698 mL 2.3396 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

427.42

Formula

C₂₂H₂₀F₃N₅O

CAS No.

1450666-80-4

SMILES

FC(F)(F)C1=CC=C(C2=NC(C3=CC=C(C(N4CCNCC4)=O)C=C3)=CN=C2N)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
UCT943
Cat. No.:
HY-112435
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UCT943

Cat. No.: HY-112435