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KDU731 

Cat. No.: HY-103583 Purity: 98.00%
Handling Instructions

KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety.

For research use only. We do not sell to patients.

KDU731 Chemical Structure

KDU731 Chemical Structure

CAS No. : 1610610-48-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 855 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].

IC50 & Target[1] [1]

PI4K

 

In Vivo

KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2].
KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool[2].

Animal Model: 6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts[1]
Dosage: 7 or 10 mg/kg
Administration: Orally administration; 7 or 10 mg/kg; 16 days
Result: Resulted in significant reduction of oocyst shedding.
Animal Model: Neonatal calves with 5 x 107 oocysts[1]
Dosage: 5 mg/kg
Administration: Orally administration; 5 mg/kg; every 12 hours for 7 days
Result: Resulted in significant reduction of oocyst shedding in treated calves in their stool.
Molecular Weight

396.40

Formula

C₂₂H₁₆N₆O₂

CAS No.

1610610-48-4

SMILES

O=C(C1=CC2=C(C3=CC=C(C(N)=O)C=C3)C=NN2C=C1)N(C)C4=NC=C(C#N)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (210.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5227 mL 12.6135 mL 25.2270 mL
5 mM 0.5045 mL 2.5227 mL 5.0454 mL
10 mM 0.2523 mL 1.2614 mL 2.5227 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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KDU731
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