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Results for "

Pentacyclic triterpenoids

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (1) Androgen Receptor (3) Apoptosis (12) ASK1 (2) Autophagy (7) Bacterial (2) Bcl-2 Family (1) Calcium Channel (1) Caspase (3) Claudin (1) COX (6) Drug Derivative (5) Endogenous Metabolite (5) ERK (2) Fatty Acid Synthase (FASN) (1) FXR (2) GSK-3 (2) HIV (3) Insecticide (2) Interleukin Related (5) Isotope-Labeled Compounds (2) JAK (1) JNK (2) LXR (2) Mitophagy (3) MMP (2) NF-κB (5) NO Synthase (1) p38 MAPK (1) Parasite (4) PI3K (1) PPAR (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) Reference Standards (8) SOD (3) STAT (1) TNF Receptor (4) Toll-like Receptor (TLR) (2) Topoisomerase (3)
By Research Areas:	Cancer (21) Cardiovascular Disease (4) Endocrinology (2) Infection (11) Inflammation/Immunology (20) Metabolic Disease (7) Neurological Disease (5)

By Targets:

Akt (1)

AMPK (1)

Androgen Receptor (3)

Apoptosis (12)

ASK1 (2)

Autophagy (7)

Bacterial (2)

Bcl-2 Family (1)

Calcium Channel (1)

Caspase (3)

Claudin (1)

COX (6)

Drug Derivative (5)

Endogenous Metabolite (5)

ERK (2)

Fatty Acid Synthase (FASN) (1)

FXR (2)

GSK-3 (2)

HIV (3)

Insecticide (2)

Interleukin Related (5)

Isotope-Labeled Compounds (2)

JAK (1)

JNK (2)

LXR (2)

Mitophagy (3)

MMP (2)

NF-κB (5)

NO Synthase (1)

p38 MAPK (1)

Parasite (4)

PI3K (1)

PPAR (1)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (8)

SOD (3)

STAT (1)

TNF Receptor (4)

Toll-like Receptor (TLR) (2)

Topoisomerase (3)

By Research Areas:

Cancer (21)

Cardiovascular Disease (4)

Endocrinology (2)

Infection (11)

Inflammation/Immunology (20)

Metabolic Disease (7)

Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0140

Ursolic acid 15+ Cited Publications Prunol; Urson; Malol	Autophagy Endogenous Metabolite	Cancer
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

HY-10529

Betulinic acid Maximum Cited Publications 35 Publications Verification Lupatic acid; Betulic acid	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier .

HY-N0790

Lupeol 5 Publications Verification Clerodol; Monogynol B; Fagarasterol	Androgen Receptor Apoptosis	Cancer
Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-N8423

α-Amyrin 1 Publications Verification	ERK GSK-3 Apoptosis Caspase COX	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin shows anti-bacterial and anti-inflammation activity. α-Amyrin can reduce blood glucose level. α-Amyrin can be used for the researches of cancer, infection, inflammation, metabolic disease and neurological disease, such as breast cancer, Streptococcus oralis infection, skin inflammation and diabetes .

HY-N1178

Taraxasterol 4 Publications Verification	Interleukin Related LXR	Inflammation/Immunology
Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases .

HY-N0611

alpha-Boswellic acid 1 Publications Verification α-Boswellic acid	Others	Neurological Disease Inflammation/Immunology Cancer
alpha-Boswellic acid (α-Boswellic acid) is an orally active pentacyclic triterpenoid compound that can be extracted from frankincense. alpha-Boswellic acid has anti-inflammatory and antitumor activities. alpha-Boswellic acid can be used in Alzheimer's disease (AD) research .

HY-N2842

α-Amyrin acetate	Apoptosis Caspase	Metabolic Disease Cancer
α-Amyrin acetate is a pentacyclic triterpenoid compound with oral activity. α-Amyrin acetate can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin acetate can reduce blood glucose level. α-Amyrin acetate can be used for the researches of cancer and metabolic disease, such as breast cancer and diabetes .

HY-N3558

Ceanothic acid Emmolic acid	Bacterial	Infection Cancer
Ceanothic acid (Emmolic acid) is an orally active pentacyclic triterpenoid. Ceanothic acid inhibits the growth of various oral bacteria, including Streptococcus mutans, Actinomyces viscosus, Porphyromonas gingivalis, and Prevotella intermedia. Ceanothic acid scavenges DPPH and H₂O₂ free radicals. Ceanothic acid inhibits acetic acid (HY-Y0319)-induced writhing response, xylene-induced ear swelling, and carrageenan-induced paw swelling in mice. Ceanothic acid can be used in research related to oral bacterial infections, ovarian cancer, liver cancer, and liver injury .

HY-N0140R

Ursolic acid (Standard) Prunol (Standard); Urson (Standard); Malol (Standard)	Reference Standards Autophagy Endogenous Metabolite	Cancer
Ursolic acid (Standard) is the analytical standard of Ursolic acid. This product is intended for research and analytical applications. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

HY-N4294

Arjungenin	FXR Insecticide	Infection Metabolic Disease Inflammation/Immunology
Arjungenin, a pentacyclic triterpenoid compound, is a FXR agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV) .

HY-N6255

Ilexgenin A	TNF Receptor	Inflammation/Immunology Cancer
Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer .

HY-N7652

Terminolic acid	Bacterial Interleukin Related	Infection Inflammation/Immunology Cancer
Terminolic acid is a pentacyclic triterpene glycoside and antibacterial agent. Terminolic acid can be isolated from Combretum racemosum. Terminolic acid inhibits proinflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6. Terminolic acid reduces IL-8. Terminolic acid has antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL. Terminolic acid is used in colon cancer research .

HY-N6850

Calenduloside E 1 Publications Verification	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species (ROS) PPAR	Cardiovascular Disease Inflammation/Immunology
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and Bcl-2 related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses .

HY-N3228

Myrianthic acid	Others	Cardiovascular Disease
Myrianthic acid is a pentacyclic triterpenoid compound. Myrianthic acid can exist in the root wood of Myrianthus arboreus and the leaves of Campsis grandiflora. Myrianthic acid inhibits adrenaline-induced platelet aggregation, with a IC₅₀ of 46.2 μM for this activity. Myrianthic acid can be used in studies related to thrombosis .

HY-N1508

Ecliptasaponin A	MMP Apoptosis Autophagy NF-κB TNF Receptor COX Toll-like Receptor (TLR) SOD ASK1 JNK	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ecliptasaponin A is an orally active pentacyclic triterpenoid saponin. Ecliptasaponin A exerts anti-tumor activity by activating ASK1/JNK pathway, inducing apoptosis and autophagy in lung cancer cells. Ecliptasaponin A exerts anti-inflammatory/anti-fibrotic effects and protects the cardiovascular system by inhibiting the HMGB1/TLR4/NF-κB pathway, and the expression of COX-2 and MMP-9. Ecliptasaponin A can enhance SOD activity, reduce MDA levels, and alleviate oxidative stress damage. Ecliptasaponin A exerts chondroprotective effects by inhibiting the expression of MMP13 and regulating inflammatory factors. Ecliptasaponin A improves ovarian function and regulates sex hormones by upregulating the expression of ESR1 receptors .

HY-10529R

Betulinic acid (Standard) Lupatic acid (Standard); Betulic acid (Standard)	Reference Standards Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Inflammation/Immunology Cancer
Betulinic acid (Standard) is the analytical standard of Betulinic acid. This product is intended for research and analytical applications. Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier.

HY-N7635

Oleanolic acid 28-O-β-D-glucopyranoside β-D-Glucopyranosyl oleanolate	NO Synthase COX Interleukin Related Claudin p38 MAPK Akt PI3K	Inflammation/Immunology
Oleanolic acid 28-O-β-D-glucopyranoside (β-D-Glucopyranosyl oleanolate) is an orally active pentacyclic triterpenoid compound. Oleanolic acid 28-O-β-D-glucopyranoside has anti-inflammatory effects. In ulcerative colitis models, Oleanolic acid 28-O-β-D-glucopyranoside can inhibit the inflammatory response, enhance the intestinal epithelial barrier function, and modulate the gut microbiota. Its mechanism of action is related to the PI3K-AKT and MAPK signaling pathways. Oleanolic acid 28-O-β-D-glucopyranoside can be used in the research of diseases such as colitis .

HY-N8879

Wilforol A (-)-Wilforol A	Others	Metabolic Disease
Wilforol A ((-)-Wilforol A), plant metabolite, is a **pentacyclic triterpenoid**. Wilforol A can be used for the research of various biochemical studies .

HY-W744739

Betulinic acid-d3 Lupatic acid-d₃; Betulic acid-d₃	Isotope-Labeled Compounds Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Inflammation/Immunology Cancer
Betulinic acid-d₃ (Lupatic acid-d₃) is a deuterium labeled Betulinic acid (HY-10529). Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier.

HY-N11601

Tripterygone	Drug Derivative	Inflammation/Immunology
Tripterygone is a chemical component that can be extracted from Tripterygium wilfordii. Tripterygone is a pentacyclic triterpenoid compound. Tripterygone is a potential anti-inflammatory agent .

HY-N1178R

Taraxasterol (Standard)	Others Interleukin Related LXR Reference Standards	Inflammation/Immunology
Taraxasterol (Standard) is the analytical standard of Taraxasterol. This product is intended for research and analytical applications. Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases .

HY-N0790R

Lupeol (Standard) Clerodol (Standard); Monogynol B (Standard); Fagarasterol (Standard)	Reference Standards Androgen Receptor Apoptosis	Cancer
Lupeol (Standard) is the analytical standard of Lupeol. This product is intended for research and analytical applications. Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-N8423R

α-Amyrin (Standard)	Reference Standards ERK GSK-3 Apoptosis Caspase COX	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
α-Amyrin (Standard) is a pentacyclic triterpenoid compound with oral activity. α-Amyrin (Standard) activates the ERK and GSK-3β signaling pathways. α-Amyrin (Standard) can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin (Standard) shows anti-bacterial and anti-inflammation activity. α-Amyrin (Standard) can reduce blood glucose level. α-Amyrin (Standard) can be used for the researches of cancer, infection, inflammation, metabolic disease and neurological disease, such as breast cancer, Streptococcus oralis infection, skin inflammation and diabetes .

HY-N8781

Tetrahymanol	Others	Others
Tetrahymanol is a pentacyclic triterpenoid that can be found in Tetrahymena pyriformis .

HY-169040

28-Aminobetulin	Fatty Acid Synthase (FASN)	Metabolic Disease
28-Aminobetulin is a pentacyclic triterpenoid and a derivative of the cholesterol biosynthesis inhibitor Betulin (HY-N0083).

HY-N3866

Esculentic acid	COX	Inflammation/Immunology
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .

HY-W744741

Lupeol-d3	Isotope-Labeled Compounds Androgen Receptor Apoptosis	Cancer
Lupeol-d₃ is the deuterium labeled Lupeol (HY-N0790). Lupeol is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor?(AR)?inhibitor and can be used for?cancer?research, especially prostate?cancer?of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-N0611R

alpha-Boswellic acid (Standard) α-Boswellic acid (Standard)	Reference Standards Others	Neurological Disease Inflammation/Immunology Cancer
alpha-Boswellic acid (Standard) is the analytical standard of alpha-Boswellic acid. This product is intended for research and analytical applications. alpha-Boswellic acid (α-Boswellic acid) is an orally active pentacyclic triterpenoid compound that can be extracted from frankincense. alpha-Boswellic acid has anti-inflammatory and antitumor activities. alpha-Boswellic acid can be used in Alzheimer's disease (AD) research .

HY-N4294R

Arjungenin (Standard)	Reference Standards FXR Insecticide	Infection Metabolic Disease Inflammation/Immunology
Arjungenin (Standard) is the analytical standard of Arjungenin. This product is intended for research and analytical applications. Arjungenin, a pentacyclic triterpenoid compound, is a FXR agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV).

HY-N9475

Betulonaldehyde	Parasite	Infection Inflammation/Immunology Cancer
Betulonaldehyde is a pentacyclic triterpenoid that can be isolated from Diospyros filipendula. Betulonaldehyde has antiplasmodial activity (IC₅₀: 3.36 µg/mL). Betulonaldehyde has cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC₅₀s: 19.23 and 17.09 µg/mL, respectively). Betulonaldehyde inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced inflammation in mice .

HY-N1508R

Ecliptasaponin A (Standard)	Reference Standards MMP Apoptosis Autophagy NF-κB TNF Receptor COX Toll-like Receptor (TLR) SOD ASK1 JNK	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ecliptasaponin A (Standard) is the analytical standard for Ecliptasaponin A (HY-N1508). Ecliptasaponin A is an orally active pentacyclic triterpenoid saponin. Ecliptasaponin A exerts anti-tumor activity by activating ASK1/JNK pathway, inducing apoptosis and autophagy in lung cancer cells. Ecliptasaponin A exerts anti-inflammatory/anti-fibrotic effects and protects the cardiovascular system by inhibiting the HMGB1/TLR4/NF-κB pathway, and the expression of COX-2 and MMP-9. Ecliptasaponin A can enhance SOD activity, reduce MDA levels, and alleviate oxidative stress damage. Ecliptasaponin A exerts chondroprotective effects by inhibiting the expression of MMP13 and regulating inflammatory factors. Ecliptasaponin A improves ovarian function and regulates sex hormones by upregulating the expression of ESR1 receptors.

HY-N17569

3β-O-trans-Feruloyl-2α,23α-dihydroxy-urs-12-en-28-oic acid	Others	Others
3β-O-trans-Feruloyl-2α,23α-dihydroxy-urs-12-en-28-oic acid (Compound 3) is a pentacyclic triterpenoid found in the fruit of Camptotheca acuminata .

HY-N18345A

Paliurusene A	Drug Derivative	Cancer
Paliurusene A is a betulinic acid-type pentacyclic triterpenoid that can be isolated from the leaves of Paliurus ramosissimus (Lour.) Poir. Paliurusene A induces growth inhibition of human hepatoma cells in vitro. Paliurusene A is applicable to research related to liver cancer .

HY-N17570

23α-Hydroxy-olean-12-en-3-one	Drug Derivative	Others
23α-Hydroxy-olean-12-en-3-one (Compound 15) is a pentacyclic triterpenoid, which is a natural derivative of the oleanane skeleton .

HY-N1856

3-O-Coumaroylarjunolic acid	Drug Derivative	Others
3-O-Coumaroylarjunolic acid is a natural triterpene.

HY-169479

Betulinic glycine amide	Drug Derivative	Infection Cancer
Betulinic glycine amide (compound 5a) is a pentacyclic triterpenoid and derivative of Betulinic acid (HY-10529). Betulinic glycine amide has been used as a precursor in the synthesis of betulinic acid derivatives with anticancer and antiviral activity .

HY-N18021

3-O-[α-L-Arabinopyranosyl]-30-norolean-12,20(29)-dien-28-oic acid	Others	Others
3-O-[α-L-Arabinopyranosyl]-30-norolean-12,20(29)-dien-28-oic acid (Compound 1) is a triterpenoid glucoside found in Stauntonia brachyanthera Hand-Mazz .

Cat. No.	Product Name	Category	Target	Chemical Structure