Ceanothic acid (Synonyms: Emmolic acid)

Name: Ceanothic acid
Brand: MedChemExpress
SKU: HY-N3558
Rating: 4.5 (1 reviews)

Cat. No.: HY-N3558 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Ceanothic acid (Emmolic acid) is an orally active pentacyclic triterpenoid. Ceanothic acid inhibits the growth of various oral bacteria, including Streptococcus mutans, Actinomyces viscosus, Porphyromonas gingivalis, and Prevotella intermedia. Ceanothic acid scavenges DPPH and H₂O₂ free radicals. Ceanothic acid inhibits acetic acid (HY-Y0319)-induced writhing response, xylene-induced ear swelling, and carrageenan-induced paw swelling in mice. Ceanothic acid can be used in research related to oral bacterial infections, ovarian cancer, liver cancer, and liver injury.

For research use only. We do not sell to patients.

Ceanothic acid Chemical Structure

CAS No. : 21302-79-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
C3H 10T1/2	IC₅₀	> 200 μM Compound: 5	Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 18842418]
DU-145	IC₅₀	> 200 μM Compound: 5	Cytotoxicity against human DU145 cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human DU145 cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 18842418]
HaCaT	IC₅₀	> 200 μM Compound: 5	Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells by luciferase based reporter gene assay Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells by luciferase based reporter gene assay	[PMID: 18842418]
HepG2	IC₅₀	> 10 μM Compound: 19	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 27617953]
PANC-1	IC₅₀	195 μM Compound: 5	Cytotoxicity against human PANC1 after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human PANC1 after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 18842418]
Raji	IC₅₀	400 molar ratio Compound: 2, CA	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA induction after 48 hrs relative to TPA Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA induction after 48 hrs relative to TPA	[PMID: 19481937]

In Vitro

Ceanothic acid (42-250 μg/mL; 48 hours) inhibits the growth of Actinomyces viscosus, Porphyromonas gingivalis, Prevotella intermedia, and Streptococcus mutans with MIC values of 42 μg/mL, 62 μg/mL, 62 μg/mL, and 250 μg/mL, respectively^[1].
Ceanothic acid (20-100 μg/mL; 30 min) exhibits dose-dependent DPPH free radical scavenging activity, with 14.1% activity at 20 μg/mL and 52.8% activity at 100 μg/mL in a cell-free assay^[2].
Ceanothic acid (48 h) inhibits OVCAR-3, HeLa, and FS-5 cells with the cell survival of 68%, 65%, and 81%, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ceanothic acid (25-50 mg/kg; p.o.; single dose) exhibits statistically significant antinociceptive activity, with 64.28% inhibition of Acetic acid (HY-Y0319)-induced writhing at 50 mg/kg (p.o.) in BALB/c mice^[2].
Ceanothic acid (25-50 mg/kg; p.o.; single dose) exhibits statistically significant anti-inflammatory activity against Xylene-induced ear edema, with 51.33% inhibition at 50 mg/kg (p.o.) in BALB/c mice^[2].
Ceanothic acid (25-50 mg/kg; i.p.; single dose) exhibits statistically significant anti-inflammatory activity against carrageenan-induced paw edema, with 33.3% inhibition at 50 mg/kg (i.p.) in BALB/c mice 5 hours post-carrageenan injection^[2].
Ceanothic acid (25-50 mg/kg; p.o.; daily; 7 days) exhibits statistically significant hepatoprotective activity against CCl₄ (HY-Y0298)-induced liver injury in BALB/c mice, with more pronounced effects at 50 mg/kg including partial restoration of serum biomarkers, reduction of lipid peroxidation, and improvement of histopathological liver damage^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c (either sex, 20-30 g)^[2]
Dosage:	25 mg/kg; 50 mg/kg
Administration:	p.o.; single dose
Result:	Inhibited acetic acid-induced writhing by a statistically significant level at 25 mg/kg. Inhibited Acetic acid-induced writhing by 64.28% at 50 mg/kg.

Animal Model:	BALB/c (either sex, 20-30 g)^[2]
Dosage:	25 mg/kg; 50 mg/kg
Administration:	p.o.; single dose
Result:	Exhibited 34% inhibitory activity against xylene-induced ear edema at 25 mg/kg. Exhibited 51.33% inhibitory activity against xylene-induced ear edema at 50 mg/kg.

Animal Model:	BALB/c (20-25 g)^[2]
Dosage:	25 mg/kg; 50 mg/kg
Administration:	i.p.; single dose
Result:	Exhibited 13.7% inhibition of carrageenan-induced paw edema at 25 mg/kg 5 hours post-carrageenan injection. Exhibited 33.3% inhibition of carrageenan-induced paw edema at 50 mg/kg 5 hours post-carrageenan injection.

Animal Model:	BALB/c (either sex, 20-30 g, carbon tetrachloride-induced liver injury)^[2]
Dosage:	25 mg/kg; 50 mg/kg
Administration:	p.o.; daily; 7 days
Result:	Significantly reduced CCl₄-induced elevations in serum alanine transaminase (ALT) and alkaline phosphatase (ALP) levels, partially restored serum total protein (TP) levels, and reduced total bilirubin (TB) levels at 25 mg/kg and 50 mg/kg. Did not significantly improve CCl₄-reduced catalase (CAT) and superoxide dismutase (SOD) activity, but reduced CCl₄-induced elevation of malondialdehyde (MDA) levels at 25 mg/kg and 50 mg/kg. Did not significantly reduce CCl₄-prolonged phenobarbital-induced sleeping time at 25 mg/kg; produced a small, non-significant reduction in sleeping time at 50 mg/kg. Caused a 0.99% loss in body weight at 25 mg/kg, and a 0.65% gain in body weight at 50 mg/kg; reduced hepatic index from 8.8% (CCl₄-only group) to 7.4% at 25 mg/kg and 6.5% at 50 mg/kg. Reduced CCl₄-induced centrilobular necrosis, piecemeal necrosis, and lymphocyte infiltration to mild levels, with mild sinusoidal congestion at 25 mg/kg; eliminated centrilobular and piecemeal necrosis, reduced lymphocyte infiltration to mild levels, and left mild sinusoidal congestion at 50 mg/kg.

Molecular Weight

486.68

Formula

C₃₀H₄₆O₅

CAS No.

21302-79-4

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@]([C@]4([C@]([C@]5([H])[C@](C(O)=O)(CC[C@H]5C(C)=C)CC4)([H])CC3)C)(CC[C@@]1([H])C(C)(C)[C@@H](O)[C@@H]2C(O)=O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (286 KB) SDS (252 KB)

COA (263 KB)

Handling Instructions (2659 KB)

References

[1]. Li XC, et al. Antimicrobial compounds from Ceanothus americanus against oral pathogens. Phytochemistry. 1997;46(1):97-102.

[2]. Abdullah, et al. Antioxidant, antinociceptive, anti-inflammatory, and hepatoprotective activities of pentacyclic triterpenes isolated from Ziziphus oxyphylla Edgew. Drug Chem Toxicol. 2022 Jul;45(4):1796-1807.

[3]. Lee SS, et al. Preparation and cytotoxic effect of ceanothic acid derivatives. J Nat Prod. 1998 Nov;61(11):1343-7. [Content Brief]

Ceanothic acid Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceanothic acid21302-79-4Emmolic acidBacterialPrevotella intermediaBALB/c miceZiziphus oxyphylla EdgewCeanothus americanusliver injuryPorphyromonas gingivalisStreptococcus mutansoral bacterial infectionsfree radicalsActinomyces viscosusInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Ceanothic acid (Synonyms: Emmolic acid)

Customer Review

Ceanothic acid Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Ceanothic acid Related Antibodies

Ceanothic acid Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report