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Results for "

Pyrimidine derivatives

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Arf Family GTPase (1) Bacterial (1) Biochemical Assay Reagents (8) Btk (1) c-Fms (1) CD44 (1) CDK (3) Cholinesterase (ChE) (1) Complement System (1) COX (2) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (13) Drug Derivative (4) Drug Intermediate (1) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (26) ERK (1) Ferroptosis (1) FGFR (2) Flavivirus (1) Fungal (1) GSK-3 (1) Histamine Receptor (1) Histone Demethylase (1) HIV (1) IFNAR (2) Isotope-Labeled Compounds (8) mTOR (1) Myosin (1) Nucleoside Antimetabolite/Analog (1) P2Y Receptor (1) Parasite (1) Phosphodiesterase (PDE) (2) PI3K (1) Potassium Channel (1) PROTACs (1) Ras (1) Reference Standards (5) Salt-inducible Kinase (SIK) (1) STAT (1)
By Research Areas:	Cancer (37) Cardiovascular Disease (4) Infection (12) Inflammation/Immunology (11) Metabolic Disease (5) Neurological Disease (15)

By Targets:

Apoptosis (1)

Arf Family GTPase (1)

Bacterial (1)

Biochemical Assay Reagents (8)

Btk (1)

c-Fms (1)

CD44 (1)

CDK (3)

Cholinesterase (ChE) (1)

Complement System (1)

COX (2)

Cytochrome P450 (1)

Dihydrofolate reductase (DHFR) (1)

DNA Alkylator/Crosslinker (2)

DNA/RNA Synthesis (13)

Drug Derivative (4)

Drug Intermediate (1)

Drug Metabolite (1)

EGFR (1)

Endogenous Metabolite (26)

ERK (1)

Ferroptosis (1)

FGFR (2)

Flavivirus (1)

Fungal (1)

GSK-3 (1)

Histamine Receptor (1)

Histone Demethylase (1)

HIV (1)

IFNAR (2)

Isotope-Labeled Compounds (8)

mTOR (1)

Myosin (1)

Nucleoside Antimetabolite/Analog (1)

P2Y Receptor (1)

Parasite (1)

Phosphodiesterase (PDE) (2)

PI3K (1)

Potassium Channel (1)

PROTACs (1)

Ras (1)

Reference Standards (5)

Salt-inducible Kinase (SIK) (1)

STAT (1)

By Research Areas:

Cancer (37)

Cardiovascular Disease (4)

Infection (12)

Inflammation/Immunology (11)

Metabolic Disease (5)

Neurological Disease (15)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Amino Acid Derivatives

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1055

Guanine 3 Publications Verification	DNA/RNA Synthesis Endogenous Metabolite	Infection Neurological Disease Cancer
Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-124719

hSMG-1 inhibitor 11j Maximum Cited Publications 14 Publications Verification	PI3K mTOR GSK-3 CDK	Cancer
hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC₅₀ of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC₅₀=50 nM), PI3Kα/γ (IC₅₀=92/60 nM) and CDK1/CDK2 (IC₅₀=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer .

HY-I0960

Uracil 4 Publications Verification	Endogenous Metabolite Drug Derivative	Infection Cancer
Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins .

HY-134772

AS1810722	STAT Cytochrome P450	Inflammation/Immunology
AS1810722 is an orally active and potent STAT6 inhibitor with an IC₅₀ of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .

HY-137265

Aminomethyltrioxsalen hydrochloride	Flavivirus	Infection
Aminomethyltrioxsalen hydrochloride is a psoralen derivative and nucleic acid intercalator. Aminomethyltrioxsalen hydrochloride can penetrate intact cells and react with nucleic acid secondary structures in vivo without disrupting the tissue structure of natural nucleoproteins. Aminomethyltrioxsalen hydrochloride inactivates viruses by crosslinking nucleic acid pyrimidine residues after exposure to UV-A radiation. Aminomethyltrioxsalen hydrochloride can be used in research related to dengue virus infection .

HY-Y1298

Methyl acetylacetate 1 Publications Verification Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives. Methyl acetoacetate can be used in the study of inflammatory diseases .

HY-Y1055A

Guanine hydrochloride 3 Publications Verification	Endogenous Metabolite DNA/RNA Synthesis	Infection Neurological Disease Cancer
Guanine hydrochloride is one of the fundamental components of nucleic acids (DNA and RNA). Guanine hydrochloride is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine hydrochloride has the potential to serve as a large-capacity N pool. Guanine hydrochloride has cytotoxic, antinociceptive and neuroprotective effects .

HY-16182

Ecamsule 1 Publications Verification	Biochemical Assay Reagents	Others
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .

HY-Y1078

DMF-DMA N-Dimethoxymethyl-N,N-dimethylamine	Biochemical Assay Reagents	Others
DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate .

HY-Y0519

Pyrimidine	Endogenous Metabolite	Neurological Disease Cancer
Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .

HY-126061

1,7-Dimethyluric acid	Biochemical Assay Reagents Drug Metabolite	Others
1,7-Dimethyluric acid is an N-methylated uric acid and purine derivative, as well as a caffeine metabolite. When 1,7-Dimethyluric acid is acted upon by peroxidase in the presence of H₂O₂, it follows the same oxidation pathway to generate a UV-absorbing intermediate, which decays via first-order kinetics. 1,7-Dimethyluric acid can adsorb onto pyrolytic graphite electrodes, but not onto glassy carbon electrodes or platinum electrodes. The N-methylation modification of its pyrimidine ring prevents ring contraction of the diol intermediate, and no NMR evidence of O-alkylation is observed during propylation under the test conditions .

HY-W003486

5,7-Dichloropyrazolo[1,5-a]pyrimidine	Phosphodiesterase (PDE)	Neurological Disease Cancer
5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a K_i of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia .

HY-126297

c-Fms-IN-10	c-Fms	Inflammation/Immunology Cancer
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulating factor-1 receptor, CSF-1R) with IC₅₀ of 2 nM. c-Fms-IN-10 has anti-tumor activity .

HY-16182A

Ecamsule disodium 1 Publications Verification	Biochemical Assay Reagents	Others
Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .

HY-W013403

2'-Deoxy-2'-fluorouridine	IFNAR	Infection
2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

HY-16398

Pipobroman	DNA Alkylator/Crosslinker DNA/RNA Synthesis	Cancer
Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .

HY-I0960S4

Uracil-d2	Endogenous Metabolite	Cancer
Uracil-d₂ is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-Y1055S3

Guanine-15N5	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Neurological Disease Cancer
Guanine- ¹⁵N₅ is ¹⁵N labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-Y1055S

Guanine-13C	DNA/RNA Synthesis Endogenous Metabolite	Neurological Disease Cancer
Guanine- ¹³C is the ¹³C labeled Guanine (HY-Y1055) . Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-Y1055R

Guanine (Standard)	Reference Standards DNA/RNA Synthesis Endogenous Metabolite	Neurological Disease Cancer
Guanine (Standard) is the analytical standard of Guanine (HY-Y1055). This product is intended for research and analytical applications. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-40181

1-Boc-homopiperazine	Drug Intermediate	Infection
1-Boc-homopiperazine is a drug intermediate that can be used for the synthesis of bacterial FtsZ inhibitors .

HY-42045

Pyrimidine-5-boronic acid pinacol ester	Drug Derivative	Others
Pyrimidine-5-boronic acid pinacol ester is a derivative of Boronic acid. Boronic acid is an intermediate commonly used in organic synthesis reactions and can be used as a key reagent in the Suzuki-Miyaura reaction. It generates organic free radicals through oxygen-mediated oxidation and exhibits potential mutagenic activity. Boronic acid is mainly used in research in the fields of drug synthesis and catalytic reactions. Pyrimidine-5-boronic acid pinacol ester serves as a building block in DNA-compatible one-pot click chemistry for synthesis of DNA-encoded libraries .

HY-I0960S1

Uracil-13C4	Endogenous Metabolite	Cancer
Uracil- ¹³C₄ is the ¹³C labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960R

Uracil (Standard)	Reference Standards Endogenous Metabolite	Cancer
Uracil (Standard) is the analytical standard of Uracil. This product is intended for research and analytical applications. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.

HY-I0960S9

Uracil-d4	Endogenous Metabolite	Cancer
Uracil-d₄ is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].

HY-Y1055S1

Guanine-13C,15N2	DNA/RNA Synthesis Endogenous Metabolite	Neurological Disease Cancer
Guanine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Guanine (HY-Y1055) . Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-Y0519R

Pyrimidine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Pyrimidine (Standard) is the analytical standard of Pyrimidine. This product is intended for research and analytical applications. Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .

HY-I0960S6

Uracil-d2-1	Endogenous Metabolite	Cancer
Uracil-d₂-1 is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960S5

Uracil-15N2	Endogenous Metabolite	Cancer
Uracil- ¹⁵N₂ is the ¹⁵N labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960S3

Uracil-13C4,15N2	Endogenous Metabolite	Cancer
Uracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-149365

SIKs-IN-1	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .

HY-178728

BION106	PROTACs Parasite Dihydrofolate reductase (DHFR)	Infection
BION106 is a dihydrofolate reductasethymidylate synthase (DHFR-TS) PROTAC degrader. BION106 exhibits extremely strong anti-malarial activity with a K_i and toxicity of 2.68 nM and 0.2 μM against Plasmodium falciparum, and > 100 μM and 44.2 μM in mammalian cells. BION106 can be used for the study of antimalarial parasites (Blue: Idasanutlin ligand (HY-15676); Pink: DHFR-TS ligand (HY-153007); Black: Linker (HY-W021401)) .

HY-I0960S

Uracil-13C2,15N2	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
Uracil- ¹³C₂, ¹⁵N₂ is the ¹³C-labeled and ¹⁵N-labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.

HY-148832

BTK-IN-20	Btk	Inflammation/Immunology Cancer
BTK-IN-20 (compound 283) is a BTK tyrosine kinase inhibitor and a 1H-pyrazolo[3,4-d]pyrimidine derivative. BTK-IN-20 can be used for the research of cancer and inflammation .

HY-164151

ERK-IN-8	ERK	Cancer
ERK-IN-8 (compound I-1) is an aniline pyrimidine derivative that acts as an ERK inhibitor. ERK-IN-8 has a strong inhibitory effect on ERK2 in vitro (IC₅₀≤50 nM). ERK-IN-8 can be used in cancer research .

HY-16182R

Ecamsule (Standard)	Biochemical Assay Reagents Reference Standards	Others
Ecamsule (Standard) is the analytical standard of Ecamsule. This product is intended for research and analytical applications. Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .

HY-179053

P2Y12/PDE5-IN-1	P2Y Receptor Phosphodiesterase (PDE)	Cardiovascular Disease
P2Y12/PDE5-IN-1 (Compound 10) is a dual-target inhibitor of P2Y12 (IC₅₀ = 0.271 μg/mL) and PDE5 (IC₅₀ = 0.154 μg/mL). P2Y12/PDE5-IN-1 can be used for research on anti-thrombosis and vasodilation .

HY-176914

Myosin-IN-3	Ferroptosis Myosin	Cardiovascular Disease Inflammation/Immunology
Myosin-IN-3 (Compound 4-1) is a pyrimidine ketone derivative. Myosin-IN-3 exhibits significant anti ferroptotic activity (IC₅₀ = 3.11 μM) while possessing myosin (IC₅₀ = 3.09 μM) inhibitory activity and antioxidant activity (DPPH EC₅₀ = 23.17 μM; MDA EC₅₀ = 55.34 μM). Myosin-IN-3 can be used for research on heart conditions such as hypertrophic cardiomyopathy .

HY-W777809

Guanine-13C2,15N	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Guanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-30139

4-Amino-2-chloropyrimidine	Biochemical Assay Reagents	Others
4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (K_i = 0.18 μM) and BChE (K_i = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC₅₀ = 0.037 μM, K_i = 0.047 μM) in vitro .

HY-172003

Isoorotidine	Nucleoside Antimetabolite/Analog	Metabolic Disease
Isoorotidine is a nucleoside derivative and an isomer of the pyrimidine nucleoside Orotidine (HY-113226).

HY-W027595

N-Benzyl-6-chloropyrimidin-4-amine	Drug Derivative	Others
N-Benzyl-6-chloropyrimidin-4-amine is a pyrimidine derivative .

HY-157578

COX-2-IN-38	COX	Inflammation/Immunology
COX-2-IN-38 (compound 52) is a potent inhibitor of COX-2, with the IC₅₀* value of 79.4 nM .

HY-157583

COX-2-IN-39	COX	Others
COX-2-IN-39 (compound 44) is a potent inhibitor of COX-2, with the IC₅₀ value of 0.4 nM .

HY-151938

Reverse transcriptase-IN-3	HIV	Infection
Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains .

HY-116150

Xymedon	Others	Cardiovascular Disease
Xymedon is a pyrimidine derivative with anti-atherosclerotic effects. Xymedon reducts plasma cholesterol levels and cholesterol esterification in blood vascular cells .

HY-167828

ARN25062	Ras	Cancer
ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative .

HY-I0960S2

Uracil-13C	Endogenous Metabolite	Cancer
Uracil- ¹³C is the ¹³C labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960S7

Uracil-d1	Endogenous Metabolite	Cancer
Uracil-d₁ is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-W049802

N-((Allyloxy)carbonyl)-N-methyl-L-alanine	Complement System	Inflammation/Immunology
N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. N-((Allyloxy)carbonyl)-N-methyl-L-alanine can be used for the synthesis of inhibitors of complement factor D. Complement factor D inhibitors can be used in the research of immune system related disease .

Cat. No.	Product Name	Type

HY-40181

1-Boc-homopiperazine	Biochemical Assay Reagents
1-Boc-homopiperazine is a drug intermediate that can be used for the synthesis of bacterial FtsZ inhibitors .

HY-42045

Pyrimidine-5-boronic acid pinacol ester

Biochemical Assay Reagents

Pyrimidine-5-boronic acid pinacol ester is a derivative of Boronic acid. Boronic acid is an intermediate commonly used in organic synthesis reactions and can be used as a key reagent in the Suzuki-Miyaura reaction. It generates organic free radicals through oxygen-mediated oxidation and exhibits potential mutagenic activity. Boronic acid is mainly used in research in the fields of drug synthesis and catalytic reactions. Pyrimidine-5-boronic acid pinacol ester serves as a building block in DNA-compatible one-pot click chemistry for synthesis of DNA-encoded libraries .

HY-30139

4-Amino-2-chloropyrimidine	Biochemical Assay Reagents
4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (K_i = 0.18 μM) and BChE (K_i = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC₅₀ = 0.037 μM, K_i = 0.047 μM) in vitro .

Cat. No.	Product Name	Target	Research Area

HY-W049802

N-((Allyloxy)carbonyl)-N-methyl-L-alanine	Complement System	Inflammation/Immunology
N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. N-((Allyloxy)carbonyl)-N-methyl-L-alanine can be used for the synthesis of inhibitors of complement factor D. Complement factor D inhibitors can be used in the research of immune system related disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y1055

Guanine 3 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis Endogenous Metabolite
Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-I0960

Uracil 4 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Drug Derivative
Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins .

HY-Y1298

Methyl acetylacetate 1 Publications Verification Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives. Methyl acetoacetate can be used in the study of inflammatory diseases .

HY-Y0519

Pyrimidine	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .

HY-126061

1,7-Dimethyluric acid	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Neurological Disease Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Source Classification	Biochemical Assay Reagents Drug Metabolite
1,7-Dimethyluric acid is an N-methylated uric acid and purine derivative, as well as a caffeine metabolite. When 1,7-Dimethyluric acid is acted upon by peroxidase in the presence of H₂O₂, it follows the same oxidation pathway to generate a UV-absorbing intermediate, which decays via first-order kinetics. 1,7-Dimethyluric acid can adsorb onto pyrolytic graphite electrodes, but not onto glassy carbon electrodes or platinum electrodes. The N-methylation modification of its pyrimidine ring prevents ring contraction of the diol intermediate, and no NMR evidence of O-alkylation is observed during propylation under the test conditions .

HY-Y1055R

Guanine (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards DNA/RNA Synthesis Endogenous Metabolite
Guanine (Standard) is the analytical standard of Guanine (HY-Y1055). This product is intended for research and analytical applications. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-I0960R

Uracil (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Endogenous Metabolite
Uracil (Standard) is the analytical standard of Uracil. This product is intended for research and analytical applications. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.

HY-Y0519R

Pyrimidine (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Pyrimidine (Standard) is the analytical standard of Pyrimidine. This product is intended for research and analytical applications. Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .

Cat. No.	Product Name	Chemical Structure

HY-I0960S4

Uracil-d2
Uracil-d₂ is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-Y1055S3

Guanine-15N5
Guanine- ¹⁵N₅ is ¹⁵N labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-Y1055S

Guanine-13C
Guanine- ¹³C is the ¹³C labeled Guanine (HY-Y1055) . Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-I0960S1

Uracil-13C4
Uracil- ¹³C₄ is the ¹³C labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960S9

Uracil-d4
Uracil-d₄ is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].

HY-Y1055S1

Guanine-13C,15N2

Guanine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Guanine (HY-Y1055) . Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-I0960S6

Uracil-d2-1
Uracil-d₂-1 is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960S5

Uracil-15N2
Uracil- ¹⁵N₂ is the ¹⁵N labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960S3

Uracil-13C4,15N2
Uracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960S

Uracil-13C2,15N2
Uracil- ¹³C₂, ¹⁵N₂ is the ¹³C-labeled and ¹⁵N-labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.

HY-W777809

Guanine-13C2,15N

Guanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-I0960S2

Uracil-13C
Uracil- ¹³C is the ¹³C labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-I0960S7

Uracil-d1
Uracil-d₁ is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-Y1055S4

Guanine-13C5
Guanine- ¹³C₅ is ¹³C-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-W778114

Guanine-13C2,7-15N

HY-Y1055S2

Guanine-13C5,15N5

Guanine- ¹³C₅, ¹⁵N₅ is ¹³C and ¹⁵N-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-W013403S

2'-Deoxy-2'-fluorouridine-d2

2'-Deoxy-2'-fluorouridine-d₂ is the deuterium labeled 2'-Deoxy-2'-fluorouridine . 2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

HY-I0960S8

Uracil-d1-1
Uracil-d₁-1 is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-Y1055S6

Guanine-d5
Guanine-d₅ is the deuterium labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-134058S

3-Heptanol-d4

3-Heptanol-d₄ (Butylethylcarbinol-d₄) is the deuterium labeled 3-Heptanol (HY-134058). 3-Heptanol is a biotransformation product of n-heptane. 3-Heptanol can act as the building block in the synthesis of 4-(3-adamantan-1-yl-ureido)-butyric acid and cyclohexanecarboxylic acid derivatives as sEH inhibitors. 3-Heptanol can be used as a solvent to form microenvironments around single-walled carbon nanotubes. 3-Heptanol can be used in the preperation of substituted pyrimidine derivatives as C1 domain-targeted isophthalate analogs to study their binding affinities towards PKCα isoform .

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