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Ecamsule disodium 

Cat. No.: HY-16182A
Handling Instructions

Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression.

For research use only. We do not sell to patients.

Ecamsule disodium Chemical Structure

Ecamsule disodium Chemical Structure

CAS No. : 90458-75-6

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Based on 1 publication(s) in Google Scholar

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Description

Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression[1][2].

In Vitro

Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1].
Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment. In the fibroblasts, Ecamsule counteractes UV and AAPH induced ROS-formation. In addition, basal ROS levels are reduced. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%. Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

606.66

Formula

C₂₈H₃₂Na₂O₈S₂

CAS No.
SMILES

O=[S](CC(C1=O)(CCC2/C1=C/C(C=C3)=CC=C3/C=C(C4=O)/C(CCC45C[S](=O)(O[Na])=O)C5(C)C)C2(C)C)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (82.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6484 mL 8.2418 mL 16.4837 mL
5 mM 0.3297 mL 1.6484 mL 3.2967 mL
10 mM 0.1648 mL 0.8242 mL 1.6484 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Ecamsule disodiumOthersUVAsunscreenradiationpyrimidinedimerInhibitorinhibitorinhibit

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Product Name:
Ecamsule disodium
Cat. No.:
HY-16182A
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