Ecamsule
Based on 1 publication(s) in Google Scholar
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
For research use only. We do not sell to patients.
- Purity: 98.02%
- CAS No.: 92761-26-7
- Formula: C28H34O8S2
- Molecular Weight:562.69
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ecamsule
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Biological Activity
Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1].
Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment[1].
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Ecamsule counteractes UV and AAPH induced ROS-formation[1].
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The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%[1].
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Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 92761-26-7
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Appearance Solid
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Molecular Weight 562.69
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Formula C28H34O8S2
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Color Light yellow to yellow
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SMILES
O=[S](CC(C1=O)(CCC2/C1=C/C(C=C3)=CC=C3/C=C(C4=O)/C(CCC45C[S](=O)(O)=O)C5(C)C)C2(C)C)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomed Pharmacother
Identification of nsp16 inhibitors of SARS -CoV-2, SARS -CoV-1 and MERS-CoV from FDA-approved drugs using in silico and in vitro methods. [Abstract]2025 Aug:189:118246. PMID: 40543162
Solvent & Solubility
Ethanol : 50 mg/mL (88.86 mM; Need ultrasonic)
Methanol : 31.25 mg/mL (55.54 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (282 KB)
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SDS (475 KB)
- English - EN (475 KB)
- Français - FR (475 KB)
- Deutsch - DE (475 KB)
- Norwegian - NO (475 KB)
- Español - ES (475 KB)
- Swedish - SV (475 KB)
- Italian - IT (475 KB)
- Korean - KR (475 KB)
- Portuguese - PT (475 KB)
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Handling Instructions (2659 KB)
References
[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244. [Content Brief]
[2]. DeLeo VA, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| Methanol / Ethanol | 1 mM | 1.7772 mL | 8.8859 mL | 17.7718 mL | 44.4294 mL |
| 5 mM | 0.3554 mL | 1.7772 mL | 3.5544 mL | 8.8859 mL | |
| 10 mM | 0.1777 mL | 0.8886 mL | 1.7772 mL | 4.4429 mL | |
| 15 mM | 0.1185 mL | 0.5924 mL | 1.1848 mL | 2.9620 mL | |
| 20 mM | 0.0889 mL | 0.4443 mL | 0.8886 mL | 2.2215 mL | |
| 25 mM | 0.0711 mL | 0.3554 mL | 0.7109 mL | 1.7772 mL | |
| 30 mM | 0.0592 mL | 0.2962 mL | 0.5924 mL | 1.4810 mL | |
| 40 mM | 0.0444 mL | 0.2221 mL | 0.4443 mL | 1.1107 mL | |
| 50 mM | 0.0355 mL | 0.1777 mL | 0.3554 mL | 0.8886 mL | |
| Ethanol | 60 mM | 0.0296 mL | 0.1481 mL | 0.2962 mL | 0.7405 mL |
| 80 mM | 0.0222 mL | 0.1111 mL | 0.2221 mL | 0.5554 mL |
Ecamsule Related Classifications
HY-16182 Related Classifications
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