CDK7-IN-33
CDK7-IN-33 is an orally active pyrimidine derivative and also a CDK7 kinase inhibitor. CDK7-IN-33 is applicable to the research of cancer, inflammation, cardiovascular diseases, infectious diseases, immune diseases and metabolic diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2640208-32-6
- 分子式: C21H20F6N6O2
- 分子量:502.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
CDK7 |
体外実験
CDK7-IN-33 (formula I) maleate crystal form Form I (0.15-333.33 nM; 3 days) potently inhibits the proliferation of 23 human cancer cell lines including ovarian, colorectal, breast, lung, pancreatic, leukemia, and lymphoma cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | Tmax | Cmax | T1/2 | AUClast |
|---|---|---|---|---|---|---|
| Rat[1] | 10 mg/kg | i.g. | 4 h | 502 ng/mL | 2.99 h | 4260 ng·h/mL |
化学情報
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CAS 番号 2640208-32-6
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分子量 502.41
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分子式 C21H20F6N6O2
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SMILES
COC(NC1=CC=C2C(C3=C(C=NC(N[C@H]4CCCNC4)=N3)C(F)(F)F)=CNC2=C1C(F)(F)F)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CDK7-IN-33 関連分類
HY-181565 関連分類
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