2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7-IN-33

CDK7-IN-33 (formula Ⅰ) is a pyrimidine derivative and also a CDK7 kinase inhibitor. CDK7-IN-33 is applicable to the research of cancer, inflammation, cardiovascular diseases, infectious diseases, immune diseases and metabolic diseases.

For research use only. We do not sell to patients.

CDK7-IN-33

CDK7-IN-33 Chemical Structure

CAS No. : 2640208-32-6

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CDK7-IN-33 Related Antibodies

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Description

CDK7-IN-33 (formula Ⅰ) is a pyrimidine derivative and also a CDK7 kinase inhibitor. CDK7-IN-33 is applicable to the research of cancer, inflammation, cardiovascular diseases, infectious diseases, immune diseases and metabolic diseases[1].

IC50 & Target

CDK7

 

In Vitro

CDK7-IN-33 (formula Ⅰ) maleate crystal form Form I (0.15-333.33 nM; 3 days) potently inhibits the proliferation of 23 human cancer cell lines including ovarian, colorectal, breast, lung, pancreatic, leukemia, and lymphoma cell lines, as demonstrated by dose-dependent anti-proliferative activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK7-IN-33 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Ovarian cancer A2780 cells, colorectal cancer WiDr cells, plus 21 additional human cancer cell lines including triple-negative breast cancer HCC70, ER+ HER2- breast cancer T47D, palbociclib-resistant breast cancer xMCF-7/palbo-R, non-small cell lung cancer A549, small cell lung cancer NCI-H446, ovarian cancer OVCAR-3, pancreatic cancer PANC-1, myeloid monocytic leukemia MV-4-11, and mantle lymphoma Mino cells
Concentration: 0.15-333.33 nM
Incubation Time: 3 days
Result: Inhibited proliferation of all 23 tested cancer cell lines, with measured anti-proliferative activity reported as IC50 values for each cell line.
In Vivo

CDK7-IN-33 (10 mg/kg; p.o.) exhibits superior in vivo pharmacokinetic properties in rats, with an AUC0-∞ of 1732.07 h*ng/mL and a Cmax of 270.53 ng/mL after oral administration of 10 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

502.41

Formula

C21H20F6N6O2
CAS No.
SMILES

COC(NC1=CC=C2C(C3=C(C=NC(N[C@H]4CCCNC4)=N3)C(F)(F)F)=CNC2=C1C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK7-IN-33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK7-IN-332640208-32-6CDKCyclin dependent kinaseovarian cell lineshuman cancer cell linesratslymphoma cell linescolorectal cell linesCDK7 kinaselung cell linesleukemia cell linesbreast cell linespancreatic cell linesInhibitorinhibitorinhibit

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