CDK7-IN-33
CDK7-IN-33 is an orally active pyrimidine derivative and also a CDK7 kinase inhibitor. CDK7-IN-33 is applicable to the research of cancer, inflammation, cardiovascular diseases, infectious diseases, immune diseases and metabolic diseases.
For research use only. We do not sell to patients.
- CAS No.: 2640208-32-6
- Formula: C21H20F6N6O2
- Molecular Weight:502.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK7 |
CDK7-IN-33 (formula I) maleate crystal form Form I (0.15-333.33 nM; 3 days) potently inhibits the proliferation of 23 human cancer cell lines including ovarian, colorectal, breast, lung, pancreatic, leukemia, and lymphoma cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Tmax | Cmax | T1/2 | AUClast |
|---|---|---|---|---|---|---|
| Rat[1] | 10 mg/kg | i.g. | 4 h | 502 ng/mL | 2.99 h | 4260 ng·h/mL |
Chemical Information
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CAS No. 2640208-32-6
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Molecular Weight 502.41
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Formula C21H20F6N6O2
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SMILES
COC(NC1=CC=C2C(C3=C(C=NC(N[C@H]4CCCNC4)=N3)C(F)(F)F)=CNC2=C1C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK7-IN-33 Related Classifications
HY-181565 Related Classifications
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