4-Amino-2-chloropyrimidine
Based on 1 Customer Validation
4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 7461-50-9
- Formula: C4H4ClN3
- Molecular Weight:129.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
4-Amino-2-chloropyrimidine inhibits AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM)[1].
4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7461-50-9
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Appearance Solid
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Molecular Weight 129.55
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Formula C4H4ClN3
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Color White to yellow
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SMILES
ClC1=NC=CC(N)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (771.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Duran H. E. (2023). Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry, 70(1), 68–82. [Content Brief]
[2]. O'Hare, T., et al., (2004). Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood, 104(8), 2532–2539. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.7190 mL | 38.5951 mL | 77.1903 mL | 192.9757 mL |
| 5 mM | 1.5438 mL | 7.7190 mL | 15.4381 mL | 38.5951 mL | |
| 10 mM | 0.7719 mL | 3.8595 mL | 7.7190 mL | 19.2976 mL | |
| 15 mM | 0.5146 mL | 2.5730 mL | 5.1460 mL | 12.8650 mL | |
| 20 mM | 0.3860 mL | 1.9298 mL | 3.8595 mL | 9.6488 mL | |
| 25 mM | 0.3088 mL | 1.5438 mL | 3.0876 mL | 7.7190 mL | |
| 30 mM | 0.2573 mL | 1.2865 mL | 2.5730 mL | 6.4325 mL | |
| 40 mM | 0.1930 mL | 0.9649 mL | 1.9298 mL | 4.8244 mL | |
| 50 mM | 0.1544 mL | 0.7719 mL | 1.5438 mL | 3.8595 mL | |
| 60 mM | 0.1287 mL | 0.6433 mL | 1.2865 mL | 3.2163 mL | |
| 80 mM | 0.0965 mL | 0.4824 mL | 0.9649 mL | 2.4122 mL | |
| 100 mM | 0.0772 mL | 0.3860 mL | 0.7719 mL | 1.9298 mL |
4-Amino-2-chloropyrimidine Related Classifications
HY-30139 Related Classifications
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