4-Amino-2-chloropyrimidine

Name: 4-Amino-2-chloropyrimidine
Brand: MedChemExpress
SKU: HY-30139
Rating: 4.5 (1 reviews)

Cat. No.: HY-30139 Pureza: 99.77%: Ficha de datos
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4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (K_i = 0.18 μM) and BChE (K_i = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC₅₀ = 0.037 μM, K_i = 0.047 μM) in vitro.

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4-Amino-2-chloropyrimidine Estructura química

No. CAS : 7461-50-9

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
25 g	En stock	Estimated Time of Arrival: December 31
50 g	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

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Revisión del cliente

Descripciòn

In Vitro

4-Amino-2-chloropyrimidine inhibits AChE (K_i = 0.18 μM) and BChE (K_i = 1.324 μM)^[1].
4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC₅₀ = 0.037 μM, K_i = 0.047 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

129.55

Fòrmula

C₄H₄ClN₃

No. CAS

7461-50-9

Appearance

Solid

Color

White to yellow

SMILES

ClC1=NC=CC(N)=N1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : ≥ 100 mg/mL (771.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.7190 mL	38.5951 mL	77.1903 mL
5 mM	1.5438 mL	7.7190 mL	15.4381 mL
10 mM	0.7719 mL	3.8595 mL	7.7190 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.77%

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Ficha de datos (271 KB) SDS (393 KB)

COA (245 KB) HNMR (116 KB) RP-HPLC (101 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Duran H. E. (2023). Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry, 70(1), 68–82. [Content Brief]

[2]. O'Hare, T., et al., (2004). Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood, 104(8), 2532–2539. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.7190 mL	38.5951 mL	77.1903 mL	192.9757 mL
	5 mM	1.5438 mL	7.7190 mL	15.4381 mL	38.5951 mL
	10 mM	0.7719 mL	3.8595 mL	7.7190 mL	19.2976 mL
	15 mM	0.5146 mL	2.5730 mL	5.1460 mL	12.8650 mL
	20 mM	0.3860 mL	1.9298 mL	3.8595 mL	9.6488 mL
	25 mM	0.3088 mL	1.5438 mL	3.0876 mL	7.7190 mL
	30 mM	0.2573 mL	1.2865 mL	2.5730 mL	6.4325 mL
	40 mM	0.1930 mL	0.9649 mL	1.9298 mL	4.8244 mL
	50 mM	0.1544 mL	0.7719 mL	1.5438 mL	3.8595 mL
	60 mM	0.1287 mL	0.6433 mL	1.2865 mL	3.2163 mL
	80 mM	0.0965 mL	0.4824 mL	0.9649 mL	2.4122 mL
	100 mM	0.0772 mL	0.3860 mL	0.7719 mL	1.9298 mL