7461-50-9
7461-50-9
Chemical Structure
4-Amino-2-chloropyrimidine
- CAS No.: 7461-50-9
- Formula:C4H4ClN3
- Molecular Weight:129.55
IUPAC Name: 2-chloropyrimidin-4-amine
InChIKey: LPBDZVNGCNTELM-UHFFFAOYSA-N
SMILES: ClC1=NC=CC(N)=N1
Biological Activity: 4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Amino-2-chloropyrimidine | 99.77% | 4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro. | ||||||||||||||||||||
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References
- [1]. Duran H. E. (2023). Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry, 70(1), 68–82. [Content Brief]
- [2]. O'Hare, T., et al., (2004). Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood, 104(8), 2532–2539. [Content Brief]
Keywords
