7461-50-9
7461-50-9
Chemical Structure
4-Amino-2-chloropyrimidine
- CAS No.: 7461-50-9
- Formula:C4H4ClN3
- Molecular Weight:129.55
IUPAC Name: 2-chloropyrimidin-4-amine
InChIKey: LPBDZVNGCNTELM-UHFFFAOYSA-N
SMILES: ClC1=NC=CC(N)=N1
Biological Activity: 4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Amino-2-chloropyrimidine | 99.77% | 4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.88
HY-301382-Amino-4-chloropyrimidine -
Similarity Score 0.84
HY-603252-Amino-4-chloropyridine -
Similarity Score 0.80
HY-593352-Amino-6-chloropyrazine -
Similarity Score 0.80
HY-W0074993-Chloro-2-pyrazinamine -
Similarity Score 0.80
HY-69014R2-O-Methylcytosine (Standard) -
Similarity Score 0.80
HY-Y1425R2-Amino-5-chloropyridine (Standard) -
Similarity Score 0.80
HY-Y01413-Amino-6-chloropyridazine -
Similarity Score 0.79
HY-Y02442-Chloropyridin-3-amine -
Similarity Score 0.79
HY-W7472182-Chloro-5-methylpyrimidin-4-amine-15N2,13C -
Explore the MedChemAI to find more analogs
References
- [1]. Duran H. E. (2023). Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry, 70(1), 68–82. [Content Brief]
- [2]. O'Hare, T., et al., (2004). Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood, 104(8), 2532–2539. [Content Brief]
