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Results for "

cPLA

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

2

Fluorescent Dyes

1

Biochemical Assay Reagents

7

Natural
Products

1

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1

Isotope-Labeled Compounds

4

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108611
    AACOCF3
    4 Publications Verification

    Arachidonyl trifluoromethyl ketone

    Phospholipase Cardiovascular Disease
    AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
    AACOCF3
  • HY-W019838
    D-Erythro-dihydrosphingosine
    1 Publications Verification

    Sphinganine (d18:0)

    Endogenous Metabolite Phospholipase Cancer
    D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
    D-Erythro-dihydrosphingosine
  • HY-103334
    MAFP
    5 Publications Verification

    Methyl Arachidonyl Fluorophosphonate

    Phospholipase Cardiovascular Disease Neurological Disease Metabolic Disease
    MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
    MAFP
  • HY-N0134
    Tanshinone I
    5 Publications Verification

    Tanshinone A

    Phospholipase Cardiovascular Disease Cancer
    Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).
    Tanshinone I
  • HY-10801
    CAY10650
    Maximum Cited Publications
    8 Publications Verification

    Phospholipase Inflammation/Immunology
    CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion .
    CAY10650
  • HY-111376
    Pyrrophenone
    4 Publications Verification

    Phospholipase Cardiovascular Disease Inflammation/Immunology
    Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM .
    Pyrrophenone
  • HY-18540
    KT109
    1 Publications Verification

    MAGL DAGL Metabolic Disease Inflammation/Immunology
    KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC50=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .
    KT109
  • HY-N10549
    Gigantol
    1 Publications Verification

    Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3 Infection Metabolic Disease Cancer
    Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .
    Gigantol
  • HY-119019
    ASB14780
    1 Publications Verification

    Phosphatase Inflammation/Immunology
    ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A2α (cPLA2α) inhibitor, with an IC50 value of 20 nM .
    ASB14780
  • HY-173371

    Phospholipase Neurological Disease
    BRI-50460 is an inhibitor of cytosolic calcium-dependent phospholipase A2 (cPLA2) that has the ability to penetrate the blood-brain barrier, with an IC50 of 0.88 nM. BRI-50460 exerts the activities of regulating neuroinflammation and restoring lipid homeostasis by inhibiting cPLA2, regulating the downstream inflammatory lipid signaling pathway, and alleviating the effects of amyloid β42 oligomers on the activation of cPLA2, the hyperphosphorylation of tau protein, and the reduction of synapses and dendrites. BRI-50460 can be applied to the research in the fields of Alzheimer's disease and other neurodegenerative diseases .
    BRI-50460
  • HY-106253

    Phospholipase Inflammation/Immunology
    Efipladib is a potent, selective and orally active cPLA2α inhibitor with an IC50 of 0.04 μM and a Kd of 0.067 μM .
    Efipladib
  • HY-14952

    PLA-695

    Phospholipase Inflammation/Immunology Cancer
    Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research .
    Giripladib
  • HY-131722

    Phospholipase Cardiovascular Disease
    EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA2 with a Ki value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis .
    EA4
  • HY-W019838S

    Sphinganine (d18:0)-d7

    Isotope-Labeled Compounds Endogenous Metabolite Phospholipase Cancer
    D-Erythro-dihydrosphingosine-d7 is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
    D-Erythro-dihydrosphingosine-d7
  • HY-U00037

    PLA 725

    Phospholipase Inflammation/Immunology
    Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.
    Ecopladib
  • HY-116301

    Phospholipase Inflammation/Immunology
    CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA2α) inhibitor with an IC50 of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases .
    CAY10502
  • HY-W127380

    Biochemical Assay Reagents Others
    Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.
    Arachidonoyl thio-PC
  • HY-W654264

    Endogenous Metabolite Integrin Cardiovascular Disease
    2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .
    2-Methylbutyrylcarnitine chloride
  • HY-D1647

    Phospholipase Others
    7-Hydroxycoumarinyl-γ-linolenate is a cytosolic phospholipase A2 (cPLA2) fluorogenic substrate. 7-Hydroxycoumarinyl-γ-linolenate can be used to monitor the enzymatic activity of cPLA2 .
    7-Hydroxycoumarinyl-γ-linolenate
  • HY-19920

    AKH-217

    Phospholipase Inflammation/Immunology
    AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis .
    AVX001
  • HY-120621

    Phospholipase Inflammation/Immunology
    BMS-229724 is an orally active and tight-binding cytosolic phospholipase A2 (cPLA2) inhibitor with an IC50 of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation .
    BMS-229724
  • HY-W713925

    Endogenous Metabolite Metabolic Disease
    Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH).1 Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.
    Diheptanoyl Thio-PC
  • HY-119094

    Phospholipase Inflammation/Immunology
    WAY-196025 is a selective and orally active indole cytosolic phospholipase A2 alpha (cPLA2α) inhibitor with an IC50 of 0.01μM and a Kd of 0.013 μM. WAY-196025 can inhibit the production of prostaglandins (such as PGE2) and leukotrienes (such as LTB4), and reduce the release of inflammatory mediators. WAY-196025 can be used for the researches of inflammation and immunology, such as asthma .
    WAY-196025
  • HY-127110

    Phospholipase Others Neurological Disease Inflammation/Immunology
    AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC50=3.8 nmol/L). AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis .
    AK106-001616
  • HY-124852

    PF 5212372

    Phospholipase Prostaglandin Receptor Leukotriene Receptor Inflammation/Immunology
    ZPL-5212372 (PF 5212372) is a cPLA2α inhibitor (IC50 = 7 nM). ZPL-5212372 inhibits the release of prostaglandin D2 (PGD2), cysteyl leukotrienes, leukotriene B4, thromboxane A2, and PGD2 from human lung cells. ZPL-5212372 inhibits delayed bronchoconstriction and airway hyperresponsiveness in a sheep allergic inflammation model. ZPL-5212372 may be used in asthma research .
    ZPL-5212372
  • HY-120050

    Phospholipase Inflammation/Immunology
    GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels .
    GK470
  • HY-138871

    Phospholipase Inflammation/Immunology
    cPLA2α-IN-derivative 1 is an inactive alcohol derivative of a highly potent Cytosolic phospholipase A2α (cPLA2α) inhibitor .
    cPLA2α-IN-derivative 1
  • HY-162368

    Phospholipase Others
    cPLA2α-IN-2 (Compound 122) is an inhibitor of cytosolic phospholipase A2α (cPLA2α) .
    cPLA2α-IN-2
  • HY-149654

    FAAH Phospholipase Neurological Disease Inflammation/Immunology
    FAAH/cPLA2α-IN-1 is a dual inhibitor of FAAH and cPLA2α with IC50s of 32 and 47 nM, respectively .
    FAAH/cPLA2α-IN-1
  • HY-162228

    COX Phospholipase Inflammation/Immunology
    VI-60 is a dual, orally active inhibitor of cPLA2 and COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA2/COX-2/PGE2 pathway .
    VI-60
  • HY-W019838R

    Sphinganine (d18:0) (Standard)

    Reference Standards Endogenous Metabolite Phospholipase Cancer
    D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
    D-Erythro-dihydrosphingosine (Standard)
  • HY-112738

    Phospholipase Inflammation/Immunology
    AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA2 with a XI(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy .
    AX048
  • HY-N0134R

    Tanshinone A (Standard)

    Reference Standards Phospholipase Cardiovascular Disease Cancer
    Tanshinone I (Standard) is the analytical standard of Tanshinone I. This product is intended for research and analytical applications. Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).
    Tanshinone I (Standard)
  • HY-138990

    Phospholipase Apoptosis Inflammation/Immunology
    GK563 is a selective Ca 2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes .
    GK563
  • HY-128061

    Phospholipase Reactive Oxygen Species (ROS) Inflammation/Immunology
    CDIBA is a cytosolic phospholipase A2 (cPLA2) inhibitor. CDIBA inhibits the activation of cPLA2 in rat diaphragm tissue. CDIBA reduces the level of mitochondrial reactive oxygen species in rat diaphragm tissue after prolonged mechanical ventilation. CDIBA attenuates protein degradation, muscle atrophy and decreased muscle strength in the diaphragm of rats after prolonged mechanical ventilation. CDIBA can be used in studies related to ventilator-induced diaphragmatic dysfunction .
    CDIBA
  • HY-103334R

    Methyl Arachidonyl Fluorophosphonate (Standard)

    Reference Standards Phospholipase Cardiovascular Disease Neurological Disease Metabolic Disease
    MAFP (Standard) is the analytical standard of MAFP (HY-103334). This product is intended for research and analytical applications. MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
    MAFP (Standard)
  • HY-N9972

    p38 MAPK Others
    Panaxcerol C (1,2-Di-O-α-linolenoyl-3-O-β-galactopyranosyl-sn-glycerol) is a plant galactolipidwith anti-inflammatory activity. It protects animals from septic shock by regulating the dynamic of oxidized lipid mediators through the MAPK-cPLA2 signaling pathway.
    Panaxcerol C
  • HY-10801R

    Reference Standards Phospholipase Inflammation/Immunology
    CAY10650 (Standard) is the analytical standard of CAY10650 (HY-10801). This product is intended for research and analytical applications. CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion .
    CAY10650 (Standard)

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