1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. Pyrrophenone

Pyrrophenone 

Cat. No.: HY-111376
Handling Instructions

Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM.

For research use only. We do not sell to patients.

Pyrrophenone Chemical Structure

Pyrrophenone Chemical Structure

CAS No. : 341973-06-6

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Description

Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM[1].

IC50 & Target[1]

cPLA2α

4.2 nM (IC50)

In Vitro

Pyrrophenone shows potent inhibition of arachidonic acid release, prostaglandin E2, thromboxane B2, and leukotriene B4 formation in human whole blood[1].
Pyrrophenone inhibits the production of arachidonic acid (AA) (IC50=24±1.7 nM), PGE2 (IC50=25±19 nM),, and LTC4 (IC50=14±6.7 nM),from THP-1 cells stimulated with A23187[1].
Pyrrophenone inhibits the production of AA (IC50=0.19±0.068 μM), PGE2 (IC50=0.20±0.047 μM), TXB2 (IC50=0.16±0.093 μM),and LTB4 (IC50=0.32±0.24 μM) from human whole blood stimulated with A23187[1].
Pyrrophenone (0.1-0.5 μM, 48 h) inhibits the growth of PC-PTC3 and PCCl3 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: PC-PTC3 and PCCl3 cells
Concentration: 0.1, 0.3, and 0.5 μM
Incubation Time: 48 hours
Result: Significantly inhibited basal PC-PTC3 cell proliferation at concentrations as low as 0.1 μM.
Basal cell proliferation of normal PCCl3 cells was also inhibited by 0.5 μM, although to a lesser extent.
In Vivo

Pyrrophenone (administered i.p. at 20 mg/kg 30 min before LPS injection.) suppresses bronchoalveolar lavage (BAL) levels of leukotriene B4 (LTB4) and platelet activating factor (PAF)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific pathogen-free female BALB/c mice[3]
Dosage: 20 mg/kg
Administration: Administered i.p. 30 min before LPS injection
Result: Suppressed the recruitment of neutrophils and eosinophils, but not macrophages.
Molecular Weight

849.96

Formula

C₄₉H₃₇F₂N₃O₅S₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Pyrrophenone
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