Pyrrophenone (Standard)
Pyrrophenone (Standard) is the analytical standard of Pyrrophenone (HY-111376). This product is intended for research and analytical applications. Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM.
For research use only. We do not sell to patients.
- CAS No.: 341973-06-6
- Formula: C49H37F2N3O5S2
- Molecular Weight:849.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 341973-06-6
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Molecular Weight 849.96
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Formula C49H37F2N3O5S2
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SMILES
O=C(NC[C@H]1N(C(C2=CC=CC=C2C(C3=CC=C(F)C=C3F)=O)=O)C[C@H](SC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C1)C7=CC=C(/C=C(SC(N8)=O)/C8=O)C=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. K Seno, et al. Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. Bioorg Med Chem Lett. 2001 Feb 26;11(4):587-90. [Content Brief]
[2]. Stefania Mariggiò, et al. Cytosolic phospholipase A2 alpha regulates cell growth in RET/PTC-transformed thyroid cells. Cancer Res. 2007 Dec 15;67(24):11769-78. [Content Brief]
[3]. C-H Lee, et al. Mechanism of glutamine inhibition of cytosolic phospholipase a2 (cPLA2 ): Evidence of physical interaction between glutamine-Induced mitogen-activated protein kinase phosphatase-1 and cPLA2. Clin Exp Immunol. 2015 Jun;180(3):571-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pyrrophenone (Standard) Related Classifications
HY-111376R Related Classifications
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