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Cat. No.: HY-19920

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AVX001

(Synonyms: AKH-217)

AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis.

For research use only. We do not sell to patients.

CAS No.: 300553-18-8
Formula: C₂₁H₂₉F₃OS
Molecular Weight:386.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (259 KB)

AVX001 Chemical Structure

CAS No.: 300553-18-8

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Price

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Quantity

Sample (0.1mg)

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(In Japan)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis^[1].

All Phospholipase Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 300553-18-8
Molecular Weight 386.51
Formula C₂₁H₂₉F₃OS
SMILES

O=C(CSC/C=C/CC/C=C\C/C=C\C/C=C\C/C=C\CC)C(F)(F)F
Synonyms

AKH-217
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. S H Omland, et al. A randomized, double-blind, placebo-controlled, dose-escalation first-in-man study (phase 0) to assess the safety and efficacy of topical cytosolic phospholipase A2 inhibitor, AVX001, in patients with mild to moderate plaque psoriasis. J Eur Acad Dermatol Venereol. 2017 Jul;31(7):1161-1167. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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