2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Phospholipase Reactive Oxygen Species (ROS)
  4. CDIBA

CDIBA is a cytosolic phospholipase A2 (cPLA2) inhibitor. CDIBA inhibits the activation of cPLA2 in rat diaphragm tissue. CDIBA reduces the level of mitochondrial reactive oxygen species in rat diaphragm tissue after prolonged mechanical ventilation. CDIBA attenuates protein degradation, muscle atrophy and decreased muscle strength in the diaphragm of rats after prolonged mechanical ventilation. CDIBA can be used in studies related to ventilator-induced diaphragmatic dysfunction.

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CDIBA

CDIBA Chemical Structure

CAS No. : 479422-22-5

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Description

CDIBA is a cytosolic phospholipase A2 (cPLA2) inhibitor. CDIBA inhibits the activation of cPLA2 in rat diaphragm tissue. CDIBA reduces the level of mitochondrial reactive oxygen species in rat diaphragm tissue after prolonged mechanical ventilation. CDIBA attenuates protein degradation, muscle atrophy and decreased muscle strength in the diaphragm of rats after prolonged mechanical ventilation. CDIBA can be used in studies related to ventilator-induced diaphragmatic dysfunction[1].

Cellular Effect
Cell Line Type Value Description References
MC9 Inhibition
-8 %
Compound: 25
Inhibition of PGF2-alpha production in the presence of exogenous arachidonic acid in MC9 cell at 1.5 uM
Inhibition of PGF2-alpha production in the presence of exogenous arachidonic acid in MC9 cell at 1.5 uM
[PMID: 16392799]
MC9 Inhibition
81 %
Compound: 25
Inhibition of PGF2-alpha production in MC9 cells at 1.5 uM
Inhibition of PGF2-alpha production in MC9 cells at 1.5 uM
[PMID: 16392799]
MC9 Inhibition
96 %
Compound: 25
Inhibition of LTB4 production in MC9 cells at 1.5 uM
Inhibition of LTB4 production in MC9 cells at 1.5 uM
[PMID: 16392799]
In Vivo

CDIBA (30 mg/kg; i.p.; single injection at ventilation onset; 5 mg/kg/h; i.v.; continuous infusion; 12 hours) attenuates ventilator-induced diaphragm dysfunction in rats by reducing cPLA2 activation, mitochondrial ROS production, calpain activity, muscle atrophy, and improving diaphragm contractile force[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (adult male, SPF level, 450-550 g, ventilator-induced diaphragm dysfunction model)[1]
Dosage: 30 mg/kg (i.p. injection); 5 mg/kg/h (continuous i.v. infusion)
Administration: i.p. (single injection at ventilation onset); i.v. (continuous infusion; 12 hours)
Result: Significantly reduced cPLA2 activation in the diaphragm.
Decreased mitochondrial H2O2 production in the diaphragm.
Downregulated diaphragm calpain activity.
Reduced the expression of atrophy-related genes Atrogin-1 and MuRF-1 in the diaphragm.
Increased the cross-sectional area of slow-twitch and fast-twitch diaphragm muscle fibers.
Improved diaphragm contractile function, including increased maximal tetanic forces, elevated force-frequency curve responses, and enhanced fatigue tolerance, compared to untreated ventilated rats.
Molecular Weight

496.00

Formula

C31H26ClNO3
CAS No.
SMILES

O=C(O)C1=CC=C(OCCC=2C=3C=C(Cl)C=CC3N(C2C)C(C=4C=CC=CC4)C=5C=CC=CC5)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDIBA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDIBA479422-22-5PhospholipaseReactive Oxygen Species (ROS)mitochondrial reactive oxygen speciescytosolic phospholipase A2protein degradationprolonged mechanical ventilationcalpain activityrat diaphragm tissuediaphragm contractile forceventilator-induced diaphragm dysfunctionmuscle atrophyInhibitorinhibitorinhibit

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