GK563
GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 2351820-19-2
- Formula: C16H22O2
- Molecular Weight:246.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Phospholipase Isoforms
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Biological Activity
IC50: 1 nM (GVIA iPLA2), 22 μM (GVIA cPLA2)[1]
GK563 (0.091 M) inhibits the activity of 100% GVIA iPLA2, 88% GVIA cPLA2 and 25% GV sPLA2[1]. GK563 (0-0.1 μM) inhibits GVIA iPLA2 with a XI(50) value of 0.0000021 and inhibits GVIA cPLA2 with an IC50 value of 22 μM[1]. GK563 (0-0.1 μM) shows a better inhibitory effect than fluoroketone FKGK18 to GVIA iPLA2 with an IC50 value of 1 nM[1]. GK563 (0-0.1 μM; 16 h) reduces β-cell apoptosis induced by proinflammatory cytokines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:β-cell line
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Concentration:0.1-10 μM
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Incubation Time:16 h
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Result:Promoted a slight but modest rise in cell death when worked alone, but produced a concentration-dependent inhibition of β-cell apoptosis by the co-treatment of cells with cytokines.
Chemical Information
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CAS No. 2351820-19-2
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Molecular Weight 246.34
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Formula C16H22O2
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SMILES
CCC[C@H]1[C@@H](C(O1)=O)CCCCC2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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