2351820-19-2
Chemical Structure
GK563
- CAS No.: 2351820-19-2
- Formula:C16H22O2
- Molecular Weight:246.34
IUPAC Name: (3S,4S)-3-(4-phenylbutyl)-4-propyloxetan-2-one
InChIKey: IAYKBJFWLAKGMR-GJZGRUSLSA-N
SMILES: CCC[C@H]1[C@@H](C(O1)=O)CCCCC2=CC=CC=C2
Biological Activity: GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes[1].
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GK563 | GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes. | |||||||||||||||||||||
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