Giripladib
Based on 1 Customer Validation
Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research.
For research use only. We do not sell to patients.
- Purity: 99.68%
- CAS No.: 865200-20-0
- Formula: C41H36ClF3N2O4S
- Molecular Weight:745.25
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Phospholipase Isoforms
More
Biological Activity
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cPLA2α |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 865200-20-0
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Appearance Solid
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Molecular Weight 745.25
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Formula C41H36ClF3N2O4S
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Color White to light yellow
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SMILES
O=C(C1=CC=C(CCCC2=C(CCNS(=O)(CC3=C(C(F)(F)F)C=CC=C3)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(C=C6)Cl)C=C1)O
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Synonyms
PLA-695
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (167.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Kokotos G, et al. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem. 2014 Sep 25;57(18):7523-35. [Content Brief]
[2]. Liu S, et al. A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties. J Hematol Oncol. 2021 Oct 29;14(1):178. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3418 mL | 6.7092 mL | 13.4183 mL | 33.5458 mL |
| 5 mM | 0.2684 mL | 1.3418 mL | 2.6837 mL | 6.7092 mL | |
| 10 mM | 0.1342 mL | 0.6709 mL | 1.3418 mL | 3.3546 mL | |
| 15 mM | 0.0895 mL | 0.4473 mL | 0.8946 mL | 2.2364 mL | |
| 20 mM | 0.0671 mL | 0.3355 mL | 0.6709 mL | 1.6773 mL | |
| 25 mM | 0.0537 mL | 0.2684 mL | 0.5367 mL | 1.3418 mL | |
| 30 mM | 0.0447 mL | 0.2236 mL | 0.4473 mL | 1.1182 mL | |
| 40 mM | 0.0335 mL | 0.1677 mL | 0.3355 mL | 0.8386 mL | |
| 50 mM | 0.0268 mL | 0.1342 mL | 0.2684 mL | 0.6709 mL | |
| 60 mM | 0.0224 mL | 0.1118 mL | 0.2236 mL | 0.5591 mL | |
| 80 mM | 0.0168 mL | 0.0839 mL | 0.1677 mL | 0.4193 mL | |
| 100 mM | 0.0134 mL | 0.0671 mL | 0.1342 mL | 0.3355 mL |
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