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Results for "

heterocyclic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) Antibiotic (1) Apoptosis (3) Aryl Hydrocarbon Receptor (1) Bacterial (6) Biochemical Assay Reagents (1) CDK (2) Complement System (4) Deubiquitinase (1) Dopamine Receptor (1) Endogenous Metabolite (4) Estrogen Receptor/ERR (1) Ferroptosis (1) FGFR (3) Fluorescent Dye (1) Fungal (1) Glucocorticoid Receptor (1) Glutathione Peroxidase (1) GSK-3 (1) Histamine Receptor (1) HIV (1) Isotope-Labeled Compounds (2) LRRK2 (1) mAChR (1) Microtubule/Tubulin (1) Mineralocorticoid Receptor (1) Monoamine Oxidase (1) Orexin Receptor (OX Receptor) (1) Orthopoxvirus (1) p38 MAPK (1) PROTACs (1) Protein Arginine Deiminase (1) Ras (1) Reactive Oxygen Species (1) Sirtuin (1) Somatostatin Receptor (1) Topoisomerase (1) Virus Protease (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (3) Endocrinology (3) Infection (10) Inflammation/Immunology (11) Metabolic Disease (4) Neurological Disease (13)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W014120

Thianthrene	Others	Infection
Thianthrene, a sulfur-containing heterocyclic compound, is a derivative of dithiin. Thianthrene can be used in the research of dermal infections, in which it interferes with enzyme and nucleic acid function .

HY-W012634

Benzothiazole	Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .

HY-111986

Trixolane

Others Others

Trixolane is a heterocyclic organic compound .
HY-149173

CDK-IN-11

CDK Cardiovascular Disease

CDK-IN-11 is a heterocyclic compound that has an action of promoting cardiomyocyte maturation .

Trixolane	Others	Others
Trixolane is a heterocyclic organic compound .

CDK-IN-11	CDK	Cardiovascular Disease
CDK-IN-11 is a heterocyclic compound that has an action of promoting cardiomyocyte maturation .

HY-151212

BCP-T.A	Ferroptosis Glutathione Peroxidase	Cancer
BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4 . BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W012634S

Benzothiazole-d4	Isotope-Labeled Compounds	Cancer
Benzothiazole-d₄ is a deuterium labeled Benzothiazole (HY-W012634). Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .

HY-141638

Me-IQ Methyl-IQ	Others	Cancer
Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits .

HY-W002820

2-Amino-5-phenylpyridine	Endogenous Metabolite	Cancer
2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic .

HY-143583

ATX inhibitor 10	Others	Neurological Disease Cancer
ATX inhibitor 10 is a potent inhibitor of ATX. ATX inhibitor 10 is s nitrogen-containing heterocyclic compound. ATX plays a role in causing pathological conditions including fibrosis, arthritis, neurodegeneration, neuropathic pain, and cancer. ATX inhibitor 10 has the potential for the research of ATX related diseases (extracted from patent WO2021115375A1, compound 35) .

HY-U00120

Picloxydine

Bacterial Infection

Picloxydine is a heterocyclic biguanide with antibacterial and antiplaque activity.
HY-107231

Xanthiside

Xanthiazone O-β-D-glucoside
Others Others

Xanthiside (Xanthiazone O-β-D-glucoside) is a heterocyclic glucoside .

Picloxydine	Bacterial	Infection
Picloxydine is a heterocyclic biguanide with antibacterial and antiplaque activity.

Xanthiside Xanthiazone O-β-D-glucoside	Others	Others
Xanthiside (Xanthiazone O-β-D-glucoside) is a heterocyclic glucoside .

HY-119517

Seclazone	Others	Inflammation/Immunology
Seclazone, a heterocyclic compound, possesses anti-inflammatory, analgesic, antipyretic and diuretic properties. Seclazone is orally active .

HY-N9998

Hirudonucleodisulfide A	Others	Others
Hirudonucleodisulfide A is a heterocyclic compound that can be found in Whitmania pigra. Hirudonucleodisulfide A shows moderately anti-anoxic activity .

HY-N10000

Hirudonucleodisulfide B	Others	Others
Hirudonucleodisulfide B is a heterocyclic compound that can be found in Whitmania pigra. Hirudonucleodisulfide B shows moderately anti-anoxic activity .

HY-137452

Suntinorexton	Orexin Receptor (OX Receptor)	Neurological Disease
Suntinorexton, a heterocyclic compound, is an orexin type 2 receptor agonist extracted from patent WO2019027058A1, page 288 .

HY-N9355

(+)-N-Formylnorglaucine	Others	Others
(+)-N-Formylnorglaucine is an aporphine alkaloid isolated from the leaves of Unonopsis stipitata. (+)-N-Formylnorglaucine contains a formyl group linked to the heterocyclic nitrogen .

HY-142487

KRAS G12C inhibitor 32

Ras Cancer

KRAS G12C inhibitor 32, an eight membered heterocyclic compound containing N, is a potent KRAS G12C inhibitor .

KRAS G12C inhibitor 32	Ras	Cancer
KRAS G12C inhibitor 32, an eight membered heterocyclic compound containing N, is a potent KRAS G12C inhibitor .

HY-103656

Tetraphenylporphyrin TPP; Tetraphenylporphine; meso-Tetraphenylporphyrin	Others	Cancer
Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research .

HY-Y0061

Oxindole 1 Publications Verification 2-Indolinone	HIV Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

HY-136476E

Cr(III) protoporphyrin IX	Others	Others
Cr(III) protoporphyrin IX is a protoporphyrin IX. Protoporphyrin IX is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway .

HY-136476F

Cd(II) protoporphyrin IX	Others	Others
Cd(II) protoporphyrin IX is a protoporphyrin IX. Protoporphyrin IX is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway .

HY-136476G

Pt(II) protoporphyrin IX	Others	Others
Pt(II) protoporphyrin IX is a protoporphyrin IX. Protoporphyrin IX is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway .

HY-15241

NVP-LCQ195

LCQ-195; AT9311
CDK Cancer

NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.

NVP-LCQ195 LCQ-195; AT9311	CDK	Cancer
NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.

HY-B1223

Anethole trithione 1 Publications Verification	mAChR	Neurological Disease Cancer
Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research .

HY-W016349

Chelidamic acid	Others	Others
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a K_i of 33 μM.

HY-12396

Aminothiazole 1 Publications Verification 2-Aminothiazole; 2-Thiazolylamine	Bacterial Fungal Virus Protease	Infection
Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators .

HY-B0548AS

Hydroxyzine D4 dihydrochloride	Histamine Receptor	Neurological Disease Inflammation/Immunology Endocrinology
Hydroxyzine-d₄ (dihydrochloride) is deuterium labeled Hydroxyzine. Hydroxyzine is a heterocyclic histamine H1-receptor antagonist. Hydroxyzine has anticholinergic, anxiolytic and analgesic properties[1].

HY-N6997

Ceratamine A	Microtubule/Tubulin	Cancer
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-118402

PD 119819	Dopamine Receptor	Neurological Disease
PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis .

HY-124855

STD1T

Deubiquitinase Cancer

STD1T is a deubiquitinase USP2a inhibitor with an IC₅₀ of 3.3 μM in Ub-AMC Assay .

STD1T	Deubiquitinase	Cancer
STD1T is a deubiquitinase USP2a inhibitor with an IC₅₀ of 3.3 μM in Ub-AMC Assay .

HY-125829

Erythropterin	Others	Others
Erythropterin is a Pterin derivative that belongs in a group of heterocyclic compounds that are frequently found in biological systems. Pterin derivatives are responsible for the characteristic warning coloration of some Heteroptera and other insects, signaling noxiousness or unpalatability and are used to discourage potential predators from attacking .

HY-W018800

4(3H)-Quinazolinone	Bacterial	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
4(3H)-Quinazolinone is a building block in chemical synthesis. Biologically active nitrogen heterocyclic compounds. Possesses a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancerous and analgesic activities .

HY-W355129S

MeIQx-d3	Isotope-Labeled Compounds	Cancer
MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129) . MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors .

HY-W001132

Indole 1 Publications Verification	Endogenous Metabolite	Infection
Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule .

HY-156403

AuM1Phe	Topoisomerase	Cancer
AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC₅₀ value of 1.2 μM .

HY-135304

PAD-IN-2	Protein Arginine Deiminase	Inflammation/Immunology Cancer
PAD-IN-2 is a potent pad4 inhibitor (IC₅₀: <1 μM). PAD-IN-2 can be used in the research of auto-immune diseases and cancers, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cystic fibrosis, asthma, multiple sclerosis and psoriasis .

HY-145657

Benzoquinoquinoxaline BQQ	Others	Others
Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with an aminoalkyl side chain. Benzoquinoquinoxaline preferentially binds to DNA triplex structures, intercalates between the bases, thus, stabilising the triplex conformation. Conjugation of Benzoquinoquinoxaline to 1,10-phenanthroline specifically binds and cleaves double strand DNA at the site of formation of a triplex structure .

HY-155011

MB076	Others	Others
MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with K_i values ＜ 1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(−) susceptibility .

HY-114856

DTBT	Biochemical Assay Reagents	Others
DTBT is a six-membered heterocyclic ring that is commonly used in the preparation of organic electronic devices, such as P-type organic semiconductors (OFETs) and P-type organic photodiodes (OLEDs). DTBT has good performance in electron transmission and photoelectric conversion. DTBT polymerizes to form donor-acceptor polymers, which are used to prepare solar cells.

HY-40294

Indazole	Monoamine Oxidase GSK-3 LRRK2	Cardiovascular Disease Neurological Disease Cancer
Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases .

HY-147604

Factor B-IN-2	Complement System	Inflammation/Immunology
Factor B-IN-2 (Example 1 target compound) is a potent complement factor B inhibitor, with an IC₅₀ of 1.5 μM. Factor B-IN-2 can be used for the research of diseases related to inflammation and immunity .

HY-147605

Factor B-IN-3	Complement System	Inflammation/Immunology
Factor B-IN-3 (Example 3 target compound) is a potent complement factor B inhibitor. Factor B-IN-3 can be used for the research of diseases related to inflammation and immunity .

HY-147606

Factor B-IN-4	Complement System	Inflammation/Immunology
Factor B-IN-4 (Example 13 target compound) is a potent complement factor B inhibitor, with an IC₅₀ of 1 μM. Factor B-IN-4 can be used for the research of diseases related to inflammation and immunity .

HY-147607

Factor B-IN-5	Complement System	Inflammation/Immunology
Factor B-IN-5 (Example 5 target compound) is a potent complement factor B inhibitor, with an IC₅₀ of 1.2 μM. Factor B-IN-5 can be used for the research of diseases related to inflammation and immunity .

HY-118716

PhIP 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine	Others	Cancer
PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat . DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity .

HY-W007355

Skatole 3 Publications Verification 3-Methylindole; 3-Methyl-1H-indole	Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Apoptosis	Others
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

HY-N6856

4-Hydroxycoumarin
4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .

HY-W001663

4'-Hydroxy-3'-methylacetophenone	Bacterial	Infection
4'-Hydroxy-3'-methylacetophenone, a phenolic volatile compound, is isolated from Hawaiian green coffee beans (Coffea Arabica L.). 4'-Hydroxy-3'-methylacetophenone has potent antioxidant activities. 4'-Hydroxy-3'-methylacetophenone also can be used to synthesize heterocyclic compounds which have antimycobacterial activity .

HY-148312

Sirtuin modulator 4	Sirtuin	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Sirtuin modulator 4 (compound 12) is a sirtuin modulator. Sirtuin modulator 4 shows inhibitory effect to SIRT1 with an EC₅₀ value of 51-100 μM. Sirtuin modulator 4 may be used for the research of increasing the lifespan of a cell, and preventing a wide variety of diseases and disorders including, for example, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, inflammation and cancer .

HY-160562

PROTAC ERα Degrader-7	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERα Degrader-7 (compound i-320) is a potent estrogen receptor alpha(ERα) PROTAC degrader with a DC₅₀ value of 0.000006 µM. PROTAC ERα Degrader-7 comprises a cereblon-binding moiety LBM linked to a ligand ERBM that binds ERα and comprises a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring .

Cat. No.	Product Name

HY-L138

Heterocyclic Compound Library

5986 compounds

Heterocyclic compounds are cyclic organic compounds which contain at least one hetero atom, the most common heteroatoms are nitrogen, oxygen ,and sulfur. Heterocycles are common in biology, featuring a wide range of structures from enzyme co-factors to amino acids and proteins. On the one hand, heterocycles are common structural units in approved drugs and in medicinal chemistry targets in the drug discovery process. In addition, heterocycles have been found as a key structure in medical chemistry and also they are frequently found in large percent of biomolecules such as vitamins, natural products ,and biologically active compounds including antifungal, anti-inflammatory, antibacterial, antioxidant, antiallergic, anti-HIV, antidiabetic, anticancer activity.

MCE offers a unique collection of 5986 heterocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE heterocyclic compound library is critical for drug discovery and development.

HY-L0094V

Chinese National Compound Library	1,398,968 compounds
The Chinese National Compound Library (CNCL) composes 1.4 million compounds possessing diversified structures. Coupled with this library will be advanced sample handling, information management and quality control systems. Most compounds in the library are drug-like, conforming to “Lipinski’s Rule of Five”, such as MW < 500, logP < 5, Hydrogen Bond Donors < 5.

HY-L0105V

InterBioScreen Synthetic Compounds Library	485,000 compounds
InterBioScreen Synthetic Compounds Library contains about 485,000 immediately available compounds. The library is generated by very rigorously selecting the most interesting classes of compounds that are most likely to become new drugs or plant protection agents or veterinary preparations.

Cat. No.	Product Name	Type

HY-D0827

Cy2

Cyanine2

Protein Labeling

Cyanines are formally compounds with two nitrogen atoms linked by an odd number of methene units. 26 28 The nitrogen atoms are parts of the heterocyclic units (such as indole, benzoxazol, or benzothiazol) . The structures and optical properties of representative cyanine dyes used for in vivo imaging are presented . Cyanines are characterized by long wavelength, tunable absorption and emission, very high extinction coefficient (up to 300,000 M 1 cm 1), good water solubility, and relatively straightforward synthesis .

Cat. No.	Product Name	Target	Research Area

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

HY-P3193A

Cyclic nona-L-arginine hydrochloride	Peptides	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P3193

Cyclic nona-L-arginine TFA

Peptides Others

Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P4102

Cyclic PSAP peptide	Peptides	Cancer
Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo .

HY-P10027

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

Cat. No.	Product Name		Classification