1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Anethole trithione

Anethole trithione 

Cat. No.: HY-B1223 Purity: 99.67%
Handling Instructions

Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research.

For research use only. We do not sell to patients.

Anethole trithione Chemical Structure

Anethole trithione Chemical Structure

CAS No. : 532-11-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 108 In-stock
Estimated Time of Arrival: December 31
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Description

Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research[1][2].

In Vitro

Anethole trithione, a slow-releasing H2S donor, is a bile secretion-stimulating drug or cholagogue that protects the liver via an increase in glutathione levels and phase II detoxifying enzymes. Anethole trithione is a potentially efficacious chemoprevention agent for lung cancer and exerts chemopreventive effects in several target organs, such as the liver and colon, by increasing the detoxification rate of carcinogens in these target organs. Anethole trithione protects blood-brain barrier integrity following cerebral ischemia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chronic treatment with Anethole trithione increases the salivary secretion from the rat submaxillary gland induced by electrical stimulation of the parasympathetic nerve and by injection of pilocarpine. In parallel with the enhancement of the salivary secretion, the number of the muscarinic acetylcholine receptors is significantly increased[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

240.36

Formula

C₁₀H₈OS₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (52.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1604 mL 20.8021 mL 41.6043 mL
5 mM 0.8321 mL 4.1604 mL 8.3209 mL
10 mM 0.4160 mL 2.0802 mL 4.1604 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Anethole trithione
Cat. No.:
HY-B1223
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