1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. PD 119819

PD 119819 

Cat. No.: HY-118402
Handling Instructions

PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis.

For research use only. We do not sell to patients.

PD 119819 Chemical Structure

PD 119819 Chemical Structure

CAS No. : 105277-43-8

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Description

PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2].

IC50 & Target[1]

Dopamine Receptor

 

In Vivo

PD 119819 (5~80 mg/kg; nasogastric intubation) makes monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values is evident after doses of 80 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey[1]
Dosage: 5~80 mg/kg
Administration: Nasogastric intubation
Result: Made monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values were evident after doses of 80 mg/kg.
Molecular Weight

438.35

Formula

C₂₁H₂₅Cl₂N₃O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PD 119819
Cat. No.:
HY-118402
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