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Pathways Recommended: Metabolic Enzyme/Protease
Results for "

human serine proteases

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

6

Peptides

1

Inhibitory Antibodies

1

Natural
Products

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-116815
    Lalistat 1
    2 Publications Verification

    		 Beta-lactamase Bacterial Infection Neurological Disease
    Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease .
    Lalistat 1
  • HY-N12586
    Pheophytin a

    		ERK Reactive Oxygen Species (ROS) COX PGE synthase STAT HCV HCV Protease Infection Neurological Disease Cancer
    Pheophytin a is a multi-target inhibitor, anticancer agent, antioxidant and antiviral agent. Pheophytin a directly binds to and inhibits HCV-NS3/4A protease (IC50=0.89 μM) to block viral replication. Pheophytin a also scavenges free radicals, reduces ferric ions, and exhibits cytotoxic activity against breast cancer cells. Pheophytin a effectively inhibits LPS-induced production of nitric oxide, prostaglandin E2, NOS2 and COX-2, as well as various pro-inflammatory cytokines, by downregulating the transcription levels of inflammatory mediators and blocking the ERK1/2 and STAT-1 pathways. In a low nerve growth factor environment, Pheophytin a also enhances ERK1/2 phosphorylation and synergistically promotes neurite outgrowth through MAPK pathway. Pheophytin a can be used to investigate the pathogenic mechanisms of diseases including chronic hepatitis C, sepsis, breast cancer and Alzheimer's disease .
    Pheophytin a
  • HY-D2363
    DOTA.SA.FAPi TFA

    		Radionuclide-Drug Conjugates (RDCs) FAP Prolyl Endopeptidase (PREP) Cancer
    DOTA.SA.FAPi TFA is a selective FAP inhibitor with an IC50 value of 0.9 nM against FAP. DOTA.SA.FAPi TFA forms stable complexes with 68Ga and serves as a PET radiotracer for preclinical imaging of FAP-expressing tumors. DOTA.SA.FAPi TFA can be used in the research of colorectal adenocarcinoma and various other cancers .
    DOTA.SA.FAPi TFA
  • HY-P1918
    Activated Protein C (390-404), human
    4 Publications Verification

    		 APC Cardiovascular Disease
    Activated Protein C (390-404), human is a polypeptide fragment of vitamin K-dependent serine protease activated protein C (APC), which inhibits the anticoagulant activity of APC. Activated Protein C (390-404), human inhibits APC-catalyzed inactivation of factor Va .
    Activated Protein C (390-404), human
  • HY-19269
    FK706

    		Elastase Inflammation/Immunology
    FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect .
    FK706
  • HY-P4284
    Z-GGF-CMK

    		Proteasome ClpP Bacterial Infection
    Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC50 of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC50 of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis .
    Z-GGF-CMK
  • HY-P5542
    Vicatertide

    SB-01; Peniel 2000

    		 Factor Xa TGF-beta/Smad Inflammation/Immunology
    Vicatertide (SB-01, Peniel 2000) is a polypeptide with both competitive inhibitory activity against TGF-β1 and selective inhibitory activity against human factor XIa (hFXIa, with a Ka of 80 nM for hFXIa). Vicatertide binds allosterically to the two binding sites of dimeric hFXI/hFXIa, while directly binding to activated TGF-β1, selectively blocking the Smad1/5/8 pathway and maintaining low-level activation of the Smad2 pathway to enhance the synthesis of type Ⅱ collagen and aggrecan. Vicatertide inhibits thrombus formation in arteriovenous thrombosis models, and also reduces thrombus weight and thrombus incidence in mouse lung cancer models. Vicatertide can be used for research on degenerative disc disease and thrombosis-related diseases .
    Vicatertide
  • HY-P2990
    Enteropeptidase

    TMPRSS15

    		 Ser/Thr Protease Metabolic Disease
    Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .
    Enteropeptidase
  • HY-148072
    MM3122

    		SARS-CoV Infection
    MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .
    MM3122
  • HY-W014134
    p-APMSF hydrochloride

    p-Amidinophenylmethylsulfonylfluoride hydrochloride

    		 Ser/Thr Protease Inflammation/Immunology
    p-APMSF (p-Amidinophenylmethylsulfonylfluoride) hydrochloride is a serine protease and trypsin inhibitor with the characteristic of rapid onset of action. p-APMSF hydrochloride reduces the enzymatic hydrolysis of recombinant human G-CSF in rat pulmonary mucosa. Combined intratracheal treatment with p-APMSF hydrochloride and Laureth-9 significantly enhances its absorption efficiency in rat lungs. Following intranasal administration, p-APMSF hydrochloride does not increase the concentration of recombinant human G-CSF in rat plasma, nor does it alter the effect of G-CSF on inducing an increase in total white blood cell count .
    p-APMSF hydrochloride
  • HY-112968
    Human protein C

    		APC Cardiovascular Disease
    Human Protein C is activated by α-thrombin or α-thrombin/thrombomodulin complex to a serine protease, namely activated protein C (APC). Human Protein C can selectively inactivate factors Va and VIIIa and is a potent anticoagulant .
    Human protein C
  • HY-172090
    MASP-2-IN-1

    		Ser/Thr Protease Inflammation/Immunology
    MASP-2-IN-1 (Compound 77) is a selective MASP-2 inhibitor with an IC50 of 0.0114 μM, and an IC50 of 13.2 μM against MASP-3. MASP-2-IN-1 inhibits the catalytic activity of MASP-2 in the lectin complement pathway. MASP-2-IN-1 is applicable to the research of immune diseases .
    MASP-2-IN-1
  • HY-122592
    Zifaxaban

    		Factor Xa Cardiovascular Disease
    Zifaxaban is an orally active, competitively and selective Factor Xa (FXa) inhibitor with an IC50 of 11.1 nM for human FXa. Zifaxaban shows >10000-fold greater selectivity than other serine proteases. Zifaxaban can be used for the arterial and venous thrombosis research .
    Zifaxaban
  • HY-150519
    FXIa/Plasma kallikrein-IN-1

    		Factor XI Kallikrein Cardiovascular Disease
    FXIa/Plasma kallikrein-IN-1 is an inhibitor of coagulation factor XIa (FXIa) and plasma kallikrein with Ki values of 187.70 nM and 151.6 nM, respectively. FXIa/Plasma kallikrein-IN-1 can be used in the research of thromboembolic diseases .
    FXIa/Plasma kallikrein-IN-1
  • HY-114164H
    Human α-Thrombin (Lyophilized)
    Maximum Cited Publications
    8 Publications Verification

    		 Thrombin Cardiovascular Disease
    Human α-thrombin is a multifunctional serine protease that plays a pivotal role in the coagulation pathway. Human α-thrombin cleaves fibrinogen and converts it into fibrin. Human α-thrombin can stimulate platelet activation and stabilize fibrin polymers .
    Human α-Thrombin (Lyophilized)
  • HY-10722
    DX-9065a

    		Factor Xa Cardiovascular Disease
    DX-9065a is a selective, nonpeptidic, and orally active factor Xa (FXa) inhibitor with a Ki of 41 nM for human FXa. DX-9065a has low activity against other serine proteases. DX-9065a has strong anticoagulant actions .
    DX-9065a
  • HY-E70389
    Human Kallikrein

    		Ser/Thr Protease Cardiovascular Disease Inflammation/Immunology
    Human Kallikrein is a serine protease that can be found in plasma and tissue. Human Kallikrein has the potential for the research of blood pressure, complement activation, and mediation and maintenance of inflammatory responses .
    Human Kallikrein
  • HY-174719
    Human ELANE mRNA

    		mRNA Inflammation/Immunology
    Human ELANE mRNA encodes the human elastase (ELANE) protein, a member of serine proteases family. ELANE may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin.
    Human ELANE mRNA
  • HY-E70566
    Protease (Fab Cleaving)

    		Ser/Thr Protease Others
    Protease (Fab Cleaving) is a serine protease expressed recombinantly in E.coli with a 6×His tag at the C-terminus. Protease (Fab Cleaving) specifically digests human IgG1 at a single site above the hinge, generating intact Fab and Fc fragments within two hours without reducing conditions.
    Protease (Fab Cleaving)
  • HY-P1918A
    Activated Protein C (390-404), human TFA

    		APC Cardiovascular Disease
    Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .
    Activated Protein C (390-404), human TFA
  • HY-P2978
    Alpha 1 Antichymotrypsin, Human Plasma

    		Ser/Thr Protease Neurological Disease
    Alpha 1 Antichymotrypsin, Human Plasma is a serine protease inhibitor. Alpha 1 Antichymotrypsin, Human Plasma appears in the amyloid lesions of Alzheimer's disease. Alpha 1 Antichymotrypsin, Human Plasma can be used in Alzheimer's disease research .
    Alpha 1 Antichymotrypsin, Human Plasma
  • HY-P991137
    Exerenibart

    		Ser/Thr Protease Metabolic Disease
    Exerenibart is an immunoglobulin G4-κ monoclonal antibody targeting human transmembrane serine protease 6 (TMPRSS6). Exerenibart is promising for research of diseases associated with iron metabolism disorders, such as iron overload or iron deficiency .
    Exerenibart
  • HY-174540
    Human SERPINA1 mRNA

    		mRNA Cancer
    Human SERPINA1 mRNA encodes the human serpin family A member 1 (SERPINA1) protein, a serine protease inhibitor belonging to the serpin superfamily. SERPINA1’s major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
    Human SERPINA1 mRNA
  • HY-126988
    SP-Chymostatin B

    α-MAPI

    		 Elastase Others
    SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase .
    SP-Chymostatin B
  • HY-10722A
    DX-9065a free base

    		Factor Xa Cardiovascular Disease
    DX-9065a free base is a selective, nonpeptidic, and orally active factor Xa (FXa) inhibitor with a Ki of 41 nM for human FXa. DX-9065a free base has low activity against other serine proteases. DX-9065a free base has strong anticoagulant actions .
    DX-9065a free base
  • HY-114015
    APC-6860

    		Ser/Thr Protease Cancer
    APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer .
    APC-6860
  • HY-162719
    RH12

    		DNA/RNA Synthesis SARS-CoV Infection
    RH12 is a dual inhibitor for SARS-CoV-2 related RNA-dependent RNA polymerase (RdRp, IC50 is 4.42 nM) and human transmembrane serine protease 2 (TMPRSS2, IC50 is 4.2 nM). RH12 exhibits antiviral efficacy. RH12 inhibits viral replication and absorption, and exhibits a 90.5% virucidal effects on Vero-E6 cells. RH12 inhibits cell viability of Calu-3 with an IC50 of 17.5 nM .
    RH12
  • HY-10281
    YM-60828 methanesulfonate

    		Factor Xa Cardiovascular Disease
    YM-60828 methanesulfonate is an orally active, selective and competitive factor Xa inhibitor with a Ki of 1.3 nM and an IC50 of 2.3 nM. YM-60828 methanesulfonate inhibits thrombus formation and platelet aggregation. YM-60828 methanesulfonate can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders .
    YM-60828 methanesulfonate
  • HY-162109
    Thrombin inhibitor 11

    		Thrombin Cardiovascular Disease
    Thrombin inhibitor 11 is an orally active, competitive and selective α-Thrombin inhibitor, with a Ki value of 65 nM against h-αThrombin and a Ki value of 10.3 nM against rat-derived α-thrombin. Thrombin inhibitor 11 can be used for the research of thrombotic diseases .
    Thrombin inhibitor 11
  • HY-181764
    LZL50

    		Ser/Thr Protease Cancer
    LZL50 is an orally effective human caseinolytic protease P (hClpP) activator with an EC50 of 0.29 μM. LZL50 activates hClpP, a serine protease that mediates mitochondrial quality control by degrading damaged or misfolded mitochondrial proteins. LZL50 exhibits antitumor activity in a breast cancer xenograft mouse model. LZL50 can be used in research related to breast cancer .
    LZL50
  • HY-180131
    INVA8001

    ASB17061

    		 Proteasome Inflammation/Immunology
    INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects .
    INVA8001
  • HY-181513
    DPP-1-IN-2

    		Interleukin Related TNF Receptor Inflammation/Immunology
    DPP-1-IN-2 is a DPP-I inhibitor with a human IC50 of 36.8 nM and oral efficacy. DPP-1-IN-2 binds to intracellular DPP-I, increases its thermal stability, and reduces the activity and expression levels of downstream neutrophil serine proteases by inhibiting its enzymatic activity. DPP-1-IN-2 regulates the secretion of inflammatory factors and chemokines to exert anti-inflammatory effects. DPP-1-IN-2 reverses joint inflammation and tissue damage in adjuvant-induced arthritis rat models. DPP-1-IN-2 is applicable to research related to arthritis .
    DPP-1-IN-2
  • HY-10279
    YM-60828 hydrochloride

    		Factor Xa Cardiovascular Disease
    YM-60828 hydrochloride is an orally active, selective and competitive factor Xa inhibitor with a Ki of 1.3 nM and an IC50 of 2.3 nM. YM-60828 hydrochloride inhibits thrombus formation and platelet aggregation. YM-60828 hydrochloride can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders .
    YM-60828 hydrochloride
  • HY-185463
    β-Tryptase-IN-1

    		Ser/Thr Protease Inflammation/Immunology
    β-Tryptase-IN-1 is a selective β-tryptase inhibitor with a Ki of 10 nM. β-Tryptase-IN-1 binds to the inducible S4 + pocket unique to β-tryptase. β-Tryptase-IN-1 can be used for the researches of asthma and chronic obstructive pulmonary disease (COPD) .
    β-Tryptase-IN-1
  • HY-165360
    JJ1

    		Thrombin Cardiovascular Disease
    JJ1 is a selective α-thrombin inhibitor with a Ki of 0.019 μM. JJ1 directly binds to the active site of α-thrombin to block its catalytic activity. JJ1 exhibits antithrombotic effects and prolongs activated partial thromboplastin time, prothrombin time, and tail bleeding time in mice. JJ1 can be used for the research of thrombotic diseases .
    JJ1

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