RH12
RH12 is a dual inhibitor for SARS-CoV-2 related RNA-dependent RNA polymerase (RdRp, IC50 is 4.42 nM) and human transmembrane serine protease 2 (TMPRSS2, IC50 is 4.2 nM). RH12 exhibits antiviral efficacy. RH12 inhibits viral replication and absorption, and exhibits a 90.5% virucidal effects on Vero-E6 cells. RH12 inhibits cell viability of Calu-3 with an IC50 of 17.5 nM.
For research use only. We do not sell to patients.
- Formula: C20H19N3O4
- Molecular Weight:365.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-3 | CC50 |
450 nM
Compound: RH12
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Cytotoxicity against human Calu-3 cells
Cytotoxicity against human Calu-3 cells
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[PMID: 39004019] |
| Vero C1008 | CC50 |
130.3 nM
Compound: RH12
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
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[PMID: 39004019] |
Chemical Information
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Molecular Weight 365.38
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Formula C20H19N3O4
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SMILES
N=C(N)NC1=CC=C(C(OC2=CC=C(OC(C=C3C(C)C)=O)C3=C2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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