country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-185463

Copy Link Print Information

β-Tryptase-IN-1

β-Tryptase-IN-1 is a selective β-tryptase inhibitor with a K_i of 10 nM. β-Tryptase-IN-1 binds to the inducible S4⁺ pocket unique to β-tryptase. β-Tryptase-IN-1 can be used for the researches of asthma and chronic obstructive pulmonary disease (COPD).

For research use only. We do not sell to patients.

CAS No.: 725228-46-6
Formula: C₂₇H₂₄F₄N₂O₄
Molecular Weight:516.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

β-Tryptase-IN-1 Chemical Structure

CAS No.: 725228-46-6

Size

Price

Stock

Quantity

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Get Quote Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Get Quote Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Bulk Inquiry

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

β-Tryptase-IN-1 (Compound 2) (0.0046-10 μM; 30 min) potently inhibits human recombinant β-tryptase with a K_i of 10 nM^[1].
β-Tryptase-IN-1 shows exquisite selectivity, with no detectable inhibition (IC₅₀ >100 μM) against factor Xa, thrombin, trypsin, elastase, or chymase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	Bioavailability	CL	T_1/2	V_ss
Rat^[1]	2 mg/kg	i.v.	/	/	/	8.4 L/h/kg	2.2 h	18.5 L/kg
Rat^[1]	10 mg/kg	p.o.	121 ng/mL	3.7 h	77 %	/	/	/

Chemical Information

CAS No. 725228-46-6
Molecular Weight 516.48
Formula C₂₇H₂₄F₄N₂O₄
SMILES

O=C(C(F)(F)F)O.O=C(N1CCC(CC1)C2=CC(CN)=CC=C2)C3=CC=C(C#CC4=C(F)C=CC=C4)O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liang G, et al. Structure-based library design and the discovery of a potent and selective mast cell β-tryptase inhibitor as an oral therapeutic agent. Bioorg Med Chem Lett. 2012;22(2):1049-1054. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock