β-Tryptase-IN-1 free base
Based on 1 Customer Validation
β-Tryptase-IN-1 free base is a selective β-tryptase inhibitor with a Ki of 10 nM. β-Tryptase-IN-1 free base binds to the inducible S4+ pocket unique to β-tryptase. β-Tryptase-IN-1 free base can be used for the researches of asthma and chronic obstructive pulmonary disease (COPD).
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 725228-45-5
- Formula: C25H23FN2O2
- Molecular Weight:402.46
-
Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
β-Tryptase-IN-1 (Compound 2) (0.0046-10 μM; 30 min) free base potently inhibits human recombinant β-tryptase with a Ki of 10 nM[1].
β-Tryptase-IN-1 free base shows exquisite selectivity, with no detectable inhibition (IC50 > 100 μM) against factor Xa, thrombin, trypsin, elastase, or chymase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 725228-45-5
-
Appearance Oil
-
Molecular Weight 402.46
-
Formula C25H23FN2O2
-
SMILES
O=C(N1CCC(CC1)C2=CC(CN)=CC=C2)C3=CC=C(C#CC4=C(F)C=CC=C4)O3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz