β-Tryptase-IN-1 free base 

β-Tryptase-IN-1 free base is a selective β-tryptase inhibitor with a K_i of 10 nM. β-Tryptase-IN-1 free base binds to the inducible S4⁺ pocket unique to β-tryptase. β-Tryptase-IN-1 free base can be used for the researches of asthma and chronic obstructive pulmonary disease (COPD)^[1].

β-Tryptase-IN-1 (Compound 2) (0.0046-10 μM; 30 min) free base potently inhibits human recombinant β-tryptase with a K_i of 10 nM^[1].
β-Tryptase-IN-1 free base shows exquisite selectivity, with no detectable inhibition (IC₅₀ > 100 μM) against factor Xa, thrombin, trypsin, elastase, or chymase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

402.46

C₂₅H₂₃FN₂O₂

725228-45-5

Oil

O=C(N1CCC(CC1)C2=CC(CN)=CC=C2)C3=CC=C(C#CC4=C(F)C=CC=C4)O3

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Liang G, et al. Structure-based library design and the discovery of a potent and selective mast cell β-tryptase inhibitor as an oral therapeutic agent. Bioorg Med Chem Lett. 2012;22(2):1049-1054.