MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is a selective MASP-2 inhibitor with an IC50 of 0.0114 μM, and an IC50 of 13.2 μM against MASP-3. MASP-2-IN-1 inhibits the catalytic activity of MASP-2 in the lectin complement pathway. MASP-2-IN-1 is applicable to the research of immune diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3103336-29-1
- Formule: C22H21N7O3S
- Masse moléculaire:463.51
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
MASP-2 0.0114 μM (IC50) |
MASP-3 13.2 μM (IC50) |
In Vitro
MASP-2-IN-1 (1 h) potently inhibits purified human MASP-2 with an IC50 of 0.0114 μM[1].
MASP-2-IN-1 (1 h) inhibits purified human MASP-3 with an IC50 of 13.2 μM, and exhibits selective activity for MASP-2 over MASP-3[1].
MASP-2-IN-1 exhibits poor stability in mouse plasma with a half-life of 4.4 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3103336-29-1
-
Masse moléculaire 463.51
-
Formule C22H21N7O3S
-
SMILES
NC1=NC(C2=CC=C(C=C2)CNC(CC3=NC=C(C=N3)NS(=O)(C4=CC=CC=C4)=O)=O)=CN1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MASP-2-IN-1 Related Classifications
HY-172090 Related Classifications
Powered by Bioz