MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is a selective MASP-2 inhibitor with an IC50 of 0.0114 μM, and an IC50 of 13.2 μM against MASP-3. MASP-2-IN-1 inhibits the catalytic activity of MASP-2 in the lectin complement pathway. MASP-2-IN-1 is applicable to the research of immune diseases.
For research use only. We do not sell to patients.
- CAS No.: 3103336-29-1
- Formula: C22H21N7O3S
- Molecular Weight:463.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MASP-2 0.0114 μM (IC50) |
MASP-3 13.2 μM (IC50) |
MASP-2-IN-1 (1 h) potently inhibits purified human MASP-2 with an IC50 of 0.0114 μM[1].
MASP-2-IN-1 (1 h) inhibits purified human MASP-3 with an IC50 of 13.2 μM, and exhibits selective activity for MASP-2 over MASP-3[1].
MASP-2-IN-1 exhibits poor stability in mouse plasma with a half-life of 4.4 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3103336-29-1
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Molecular Weight 463.51
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Formula C22H21N7O3S
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SMILES
NC1=NC(C2=CC=C(C=C2)CNC(CC3=NC=C(C=N3)NS(=O)(C4=CC=CC=C4)=O)=O)=CN1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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