2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Anti-infection
  3. Proteasome ClpP Bacterial
  4. Z-GGF-CMK

Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC50 of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC50 of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-GGF-CMK

Z-GGF-CMK Chemical Structure

CAS No. : 35172-59-9

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Z-GGF-CMK Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC50 of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC50 of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis[1].

IC50 & Target[1]

ClpP1P2

50 μM (IC50)

In Vitro

Z-GGF-CMK (24 h) inhibits intracellular ClpP1P2 protease activity in M. bovis BCG with an IC50 of 50 μM[1].
Z-GGF-CMK (2 h) inhibits proteasome activity in M. bovis BCG with an IC50 of 50 μM[1].
Z-GGF-CMK (2 h) is inactive against human proteasome activity in HepG2 cells at concentrations up to 500 μM[1].
Z-GGF-CMK (5 days) inhibits M. bovis BCG growth with an MIC50 of 30 μM[1].
Z-GGF-CMK (5 days) inhibits M. tuberculosis H37Rv growth with an MIC50 of 30 μM[1].
Z-GGF-CMK exhibits cytotoxicity against HepG2 cells with a CC50 of 125 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z-GGF-CMK Related Antibodies
Molecular Weight

445.90

Formula

C22H24ClN3O5
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Cbz}-Gly-Gly-Phe-{CMK}
Sequence Shortening

{Cbz}-GGF-{CMK}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (224.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2427 mL 11.2133 mL 22.4266 mL
5 mM 0.4485 mL 2.2427 mL 4.4853 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2427 mL 11.2133 mL 22.4266 mL 56.0664 mL
5 mM 0.4485 mL 2.2427 mL 4.4853 mL 11.2133 mL
10 mM 0.2243 mL 1.1213 mL 2.2427 mL 5.6066 mL
15 mM 0.1495 mL 0.7476 mL 1.4951 mL 3.7378 mL
20 mM 0.1121 mL 0.5607 mL 1.1213 mL 2.8033 mL
25 mM 0.0897 mL 0.4485 mL 0.8971 mL 2.2427 mL
30 mM 0.0748 mL 0.3738 mL 0.7476 mL 1.8689 mL
40 mM 0.0561 mL 0.2803 mL 0.5607 mL 1.4017 mL
50 mM 0.0449 mL 0.2243 mL 0.4485 mL 1.1213 mL
60 mM 0.0374 mL 0.1869 mL 0.3738 mL 0.9344 mL
80 mM 0.0280 mL 0.1402 mL 0.2803 mL 0.7008 mL
100 mM 0.0224 mL 0.1121 mL 0.2243 mL 0.5607 mL
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Z-GGF-CMK Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-GGF-CMK35172-59-9ProteasomeClpPBacterialCaseinolytic protease PM. tuberculosis H37Rvhuman proteasomemycobacterial proteasometuberculosismammalian cellsHepG2 cellsM. bovis BCGClpP1P2 serine protease complexmycobacteriaInhibitorinhibitorinhibit

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