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murine iNOS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (1) Autophagy (1) Caspase (1) COX (7) ERK (1) IFNAR (2) Interleukin Related (4) JAK (2) JNK (1) Keap1-Nrf2 (1) MMP (2) nAChR (2) NF-κB (6) NO Synthase (15) p38 MAPK (2) PGE synthase (2) PI3K (2) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SOD (1) STAT (3) TNF Receptor (1) Toll-like Receptor (TLR) (1) Tyrosinase (1) VEGFR (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (12) Neurological Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P991316

KD014 DX-2400; DX-2410	MMP NO Synthase	Inflammation/Immunology Cancer
KD014 (DX-2400) is a human monoclonal antibody that selectively targets MMP‑14. KD014 inhibits collagen degradation and regulates the polarization of macrophages toward an anti-inflammatory/anti-tumor phenotype. KD014 alleviates joint damage in rheumatoid arthritis and suppresses tumor growth and invasion. KD014 can be used in studies related to breast cancer and rheumatoid arthritis .

HY-118700

2-Iminobiotin Guanidinobiotin	NO Synthase	Neurological Disease
2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with K_is of 21.8 and 37.5μM for murine *iNOS* and rat n-cNOS, respectively . 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage .

HY-N2106

Dehydroevodiamine 2 Publications Verification	NF-κB COX PGE synthase NO Synthase	Inflammation/Immunology
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced *iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine* macrophage cells .

HY-P10710

BMP-4 (15-24)	IFNAR Interleukin Related COX NO Synthase	Inflammation/Immunology
BMP-4 (15-24) is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) can be used in the research of arthritis .

HY-146066

α7 nAchR-JAK2-STAT3 agonist 1	nAChR JAK STAT NO Synthase Interleukin Related	Inflammation/Immunology
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .

HY-P10710A

BMP-4 (15-24) acetate 1 Publications Verification	IFNAR Interleukin Related COX NO Synthase	Inflammation/Immunology
BMP-4 (15-24) acetate is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) acetate exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) acetate can be used in the research of arthritis .

HY-N7700

Guluronic acid G2013	MMP COX VEGFR Toll-like Receptor (TLR) NF-κB NO Synthase	Inflammation/Immunology Cancer
Guluronic acid (G2013) is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid up-regulates the expression of immunoregulatory genes SHIP1 and SOCS1, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases .

HY-118700A

2-Iminobiotin hydrobromide Guanidinobiotin hydrobromide	NO Synthase	Neurological Disease
2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with K_is of 21.8 and 37.5 μM for murine *iNOS* and rat n-cNOS, respectively . 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage .

HY-161612

Mycosporine 2 glycine	Tyrosinase SOD COX NO Synthase Keap1-Nrf2	Inflammation/Immunology
Mycosporine 2 glycine is an anti-inflammatory agent and TYRP1 inhibitor. Mycosporine 2 glycine inhibits the expression of inflammatory genes and reduces nitric oxide production. Mycosporine 2 glycine binds tightly to the active pocket of TYRP1 and inhibits the activity of melanogenesis-related enzymes. Mycosporine 2 glycine can be used in the research of hyperpigmentation and inflammation-related diseases .

HY-N8712

Umckalin	p38 MAPK JNK ERK TNF Receptor Interleukin Related PI3K Akt	Inflammation/Immunology
Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE₂ production. Umckalin can be used for the research of chronic inflammatory diseases .

HY-146066A

(R)-α7 nAchR-JAK2-STAT3 agonist 1	nAChR JAK STAT NO Synthase	Others
(R)-α7 nAchR-JAK2-STAT3 agonist 1 is the R-enantiomer of α7 nAchR-JAK2-STAT3 agonist 1 (HY-146066). α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .

HY-N2106R

Dehydroevodiamine (Standard)	Reference Standards NF-κB COX PGE synthase NO Synthase	Inflammation/Immunology
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

HY-N16376

Thienodolin MJ 286A	NF-κB STAT	Inflammation/Immunology
Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC₅₀ value of 17.2 μM. Thienodolin suppresses *iNOS, blocks the degradation of IκBα, attenuates NF-κB* p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation .

HY-170585

COX-2-IN-51	COX NF-κB	Inflammation/Immunology
COX-2-IN-51 (E25) is a potent COX-2 inhibitor, with an IC₅₀ of 70.7 nM. COX-2-IN-51 significantly inhibits LPS-induced release of NO and PGE2, expression of COX-2 and iNOS, and activation of NF-κB pathway. COX-2-IN-51 exhibits anti-inflammatory and analgesic effects in diverse murine models through inhibiting NF-κB pathway. COX-2-IN-51 has lower gastrointestinal side effects than Indomethacin (HY-14397) .

HY-149523

Anticancer agent 157	Apoptosis NO Synthase Caspase	Inflammation/Immunology Cancer
Anticancer agent 157 (compound 15) is a NO inhibitor (IC₅₀=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC₅₀=2.45 μg/mL), Hep-G2 liver cancer cells (IC₅₀=3.25 μg/mL), and B16-F10 murine melanoma cells (IC₅₀=3.84 μg/mL) .

HY-N19854

Mariaterpenoside A	NO Synthase	Neurological Disease
Mariaterpenoside A is an inducible nitric oxide synthase (iNOS) inhibitor. Mariaterpenoside A interacts with the active cavity of iNOS protein via hydrogen bonds with specific residues of the binding site. Mariaterpenoside A suppresses NO release in LPS (HY-D1056)-induced murine microglial BV-2 cells. Mariaterpenoside A can be used for the research of neurodegenerative disease .

HY-120340

nNOS-IN-7	NO Synthase	Neurological Disease
nNOS-IN-7 is a selective nNOS inhibitor with a K_i value of 0.049 μM against rat nNOS. nNOS-IN-7 is applicable to the research of neurodegenerative diseases .

HY-182236

JRN73958 Reduced scytonemin	PI3K p38 MAPK NF-κB NO Synthase Reactive Oxygen Species (ROS) Autophagy	Cancer
JRN73958 (Reduced scytonemin) is a PI3K/Akt, MAPK, and NF-κB inhibitor found in Nostoc commune. JRN73958 inhibits nitric oxide production, induce reactive oxygen species (ROS) generation, and lead to autophagy. JRN73958 decreases LPS (HY-D1056)/IFNγ-induced PI3K/Akt, MAPK, and NF-κB activity. JRN73958 can be used for the research of leukemia .

Cat. No.	Product Name	Target	Research Area

HY-P10710

BMP-4 (15-24)	IFNAR Interleukin Related COX NO Synthase	Inflammation/Immunology
BMP-4 (15-24) is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) can be used in the research of arthritis .

HY-P10710A

BMP-4 (15-24) acetate 1 Publications Verification	IFNAR Interleukin Related COX NO Synthase	Inflammation/Immunology
BMP-4 (15-24) acetate is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) acetate exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) acetate can be used in the research of arthritis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991316

KD014 DX-2400; DX-2410	MMP NO Synthase	Inflammation/Immunology Cancer
KD014 (DX-2400) is a human monoclonal antibody that selectively targets MMP‑14. KD014 inhibits collagen degradation and regulates the polarization of macrophages toward an anti-inflammatory/anti-tumor phenotype. KD014 alleviates joint damage in rheumatoid arthritis and suppresses tumor growth and invasion. KD014 can be used in studies related to breast cancer and rheumatoid arthritis .

Dehydroevodiamine 2 Publications Verification	Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced *iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine* macrophage cells .

Umckalin	Structural Classification Monophenols Classification of Application Fields Other Diseases Coumarins Phenols Pelargonium hortorum Phenylpropanoids Plants Geraniaceae Disease Research Fields Source Classification	p38 MAPK JNK ERK TNF Receptor Interleukin Related PI3K Akt
Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE₂ production. Umckalin can be used for the research of chronic inflammatory diseases .

Dehydroevodiamine (Standard)	Alkaloids Structural Classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Indole Alkaloids Source Classification	Reference Standards NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

Thienodolin MJ 286A	Alkaloids Microorganisms Pyridine Alkaloids Source Classification	NF-κB STAT
Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC₅₀ value of 17.2 μM. Thienodolin suppresses *iNOS, blocks the degradation of IκBα, attenuates NF-κB* p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation .

Mariaterpenoside A	Structural Classification Glycine soya Plants Compositae Saccharides Monosaccharides Source Classification	NO Synthase
Mariaterpenoside A is an inducible nitric oxide synthase (iNOS) inhibitor. Mariaterpenoside A interacts with the active cavity of iNOS protein via hydrogen bonds with specific residues of the binding site. Mariaterpenoside A suppresses NO release in LPS (HY-D1056)-induced murine microglial BV-2 cells. Mariaterpenoside A can be used for the research of neurodegenerative disease .

JRN73958 Reduced scytonemin	Structural Classification Alkaloids Microorganisms Other Alkaloids Source Classification	PI3K p38 MAPK NF-κB NO Synthase Reactive Oxygen Species (ROS) Autophagy
JRN73958 (Reduced scytonemin) is a PI3K/Akt, MAPK, and NF-κB inhibitor found in Nostoc commune. JRN73958 inhibits nitric oxide production, induce reactive oxygen species (ROS) generation, and lead to autophagy. JRN73958 decreases LPS (HY-D1056)/IFNγ-induced PI3K/Akt, MAPK, and NF-κB activity. JRN73958 can be used for the research of leukemia .

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murine iNOS

Inhibitors & Agonists

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