2. Immunology/Inflammation
  3. IFNAR Interleukin Related COX NO Synthase
  4. BMP-4 (15-24) acetate

BMP-4 (15-24) acetate is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) acetate exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) acetate can be used in the research of arthritis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

BMP-4 (15-24) acetate

BMP-4 (15-24) acetate Chemical Structure

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of BMP-4 (15-24) acetate:

BMP-4 (15-24) acetate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BMP-4 (15-24) acetate

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

View All NO Synthase Isoform Specific Products:

View All Isoforms
nNOS iNOS eNOS

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMP-4 (15-24) acetate is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) acetate exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) acetate can be used in the research of arthritis[1][2].

IC50 & Target[2]

IL-6

 

COX-2

 

In Vitro

BMP-4 (15-24) (0-100 μg/mL; 24 h) acetate inhibits the expression of inflammatory proteins including iNOS, COX2, IFNγ, and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 macrophages[2].
BMP-4 (15-24) (0-100 μg/mL) acetate dose-dependently upregulates the mRNA expression of cartilage marker genes AGG, COLII, and TNFα in human articular chondrocytes NHAC[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMP-4 (15-24) acetate Related Antibodies

Western Blot Analysis[2]

Cell Line: LPS treated RAW264.7
Concentration: 0, 10, 50, 100 μg/mL
Incubation Time: 24 h
Result: Inhibited the levels of iNOS, COX-2, IFNγ and IL6 in a dose-dependent manner.
In Vivo

BMP-4 (15-24) (30 mg/kg; subcutaneous injection; twice weekly for 4 consecutive weeks) acetate exhibits anti-inflammatory and protective activities in a mouse model of arthritis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1 mice (male, 21-24 g, 7 weeks old) with collagen-induced arthritis (CIA)[2]
Dosage: 30 mg/kg
Administration: subcutaneous injection; twice weekly for 4 consecutive weeks
Result: Significantly reduced the arthritis score and hind paw swelling degree, and inhibits the serum concentrations of proinflammatory cytokines IFNγ and IL-6.
Alleviated synovial hyperplasia, pannus formation and bone erosion, and repairs the damage of glycosaminoglycan (GAG) area in articular cartilage.
Molecular Weight

1308.52 (free base)

Formula

C52H93N25O13S.xC2H4O2
Appearance

Crystal

Color

White to off-white

Sequence

Arg-Lys-Lys-Asn-Pro-Asn-Cys-Arg-Arg-His
Sequence Shortening

RKKNPNCRRH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BMP-4 (15-24) acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMP-4 (15-24)IFNARInterleukin RelatedCOXNO SynthaseInterferon-α/β receptorInterferon-alpha/beta receptor ILCyclooxygenaseNitric oxide synthasesNOSIL6macrophagesBMP-4rheumatic arthritisiNOSIFNbone morphogenetic proteinCOX2murine chondrocytesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BMP-4 (15-24) acetate
Cat. No.:
HY-P10710A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.