2. Immunology/Inflammation
  3. IFNAR Interleukin Related COX NO Synthase
  4. BMP-4 (15-24)

BMP-4 (15-24) is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) can be used in the research of arthritis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

BMP-4 (15-24)

BMP-4 (15-24) Chemical Structure

CAS No. : 1629625-47-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of BMP-4 (15-24):

Other Forms of BMP-4 (15-24):

BMP-4 (15-24) Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BMP-4 (15-24)

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

View All NO Synthase Isoform Specific Products:

View All Isoforms
nNOS iNOS eNOS

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMP-4 (15-24) is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) can be used in the research of arthritis[1][2].

IC50 & Target[2]

IL-6

 

COX-2

 

In Vitro

BMP-4 (15-24) (0-100 μg/mL; 24 h) inhibits the expression of inflammatory proteins including iNOS, COX2, IFNγ, and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 macrophages[2].
BMP-4 (15-24) (0-100 μg/mL) dose-dependently upregulates the mRNA expression of cartilage marker genes AGG, COLII, and TNFα in human articular chondrocytes NHAC[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMP-4 (15-24) Related Antibodies

Western Blot Analysis[2]

Cell Line: LPS treated RAW264.7
Concentration: 0, 10, 50, 100 μg/mL
Incubation Time: 24 h
Result: Inhibited the levels of iNOS, COX-2, IFNγ and IL6 in a dose-dependent manner.
In Vivo

BMP-4 (15-24) (30 mg/kg; subcutaneous injection; twice weekly for 4 consecutive weeks) exhibits anti-inflammatory and protective activities in a mouse model of arthritis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1 mice (male, 21-24 g, 7 weeks old) with collagen-induced arthritis (CIA)[2]
Dosage: 30 mg/kg
Administration: subcutaneous injection; twice weekly for 4 consecutive weeks
Result: Significantly reduced the arthritis score and hind paw swelling degree, and inhibits the serum concentrations of proinflammatory cytokines IFNγ and IL-6.
Alleviated synovial hyperplasia, pannus formation and bone erosion, and repairs the damage of glycosaminoglycan (GAG) area in articular cartilage.
Molecular Weight

1308.52

Formula

C52H93N25O13S
CAS No.
Sequence

Arg-Lys-Lys-Asn-Pro-Asn-Cys-Arg-Arg-His
Sequence Shortening

RKKNPNCRRH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BMP-4 (15-24) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMP-4 (15-24)1629625-47-3IFNARInterleukin RelatedCOXNO SynthaseInterferon-α/β receptorInterferon-alpha/beta receptor ILCyclooxygenaseNitric oxide synthasesNOSIL6macrophagesBMP-4rheumatic arthritisiNOSIFNbone morphogenetic proteinCOX2murine chondrocytesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BMP-4 (15-24)
Cat. No.:
HY-P10710
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.