2. Immunology/Inflammation
  3. NO Synthase
  4. 2-Iminobiotin hydrobromide

2-Iminobiotin hydrobromide  (Synonyms: Guanidinobiotin hydrobromide)

Cat. No.: HY-118700A Purity: ≥98.0%
COA Handling Instructions

2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage.

For research use only. We do not sell to patients.

2-Iminobiotin hydrobromide Chemical Structure

2-Iminobiotin hydrobromide Chemical Structure

CAS No. : 76985-52-9

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Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 165 In-stock
Solid
10 mg USD 150 In-stock
50 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].

IC50 & Target

NO synthases[1]
In Vitro

Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

324.24

Appearance

Solid

Formula

C10H18BrN3O2S
CAS No.
SMILES

[H][[email protected]](CS[[email protected]]1CCCCC(O)=O)([[email protected]]1([H])N2)NC2=N.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (385.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0841 mL 15.4207 mL 30.8414 mL
5 mM 0.6168 mL 3.0841 mL 6.1683 mL
10 mM 0.3084 mL 1.5421 mL 3.0841 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

2-Iminobiotin76985-52-9GuanidinobiotinNO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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