1. Immunology/Inflammation
  2. NO Synthase
  3. 2-Iminobiotin hydrobromide

2-Iminobiotin hydrobromide (Synonyms: Guanidinobiotin hydrobromide)

Cat. No.: HY-118700A Purity: >98.0%
Handling Instructions

2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage.

For research use only. We do not sell to patients.

2-Iminobiotin hydrobromide Chemical Structure

2-Iminobiotin hydrobromide Chemical Structure

CAS No. : 76985-52-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].

IC50 & Target

NO synthases[1]

In Vitro

Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control[1].

Molecular Weight

324.24

Formula

C₁₀H₁₈BrN₃O₂S

CAS No.

76985-52-9

SMILES

[H][[email protected]](CS[[email protected]]1CCCCC(O)=O)([[email protected]]1([H])N2)NC2=N.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (385.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0841 mL 15.4207 mL 30.8414 mL
5 mM 0.6168 mL 3.0841 mL 6.1683 mL
10 mM 0.3084 mL 1.5421 mL 3.0841 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

2-IminobiotinGuanidinobiotinNO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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Product Name:
2-Iminobiotin hydrobromide
Cat. No.:
HY-118700A
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